Abstract: A power tool, in particular a hand-held power tool, includes a tool-holding device that rotates about an output axis. The tool-holding device is configured to hold a tool device on the power tool such that the output axis and a tool rotation axis substantially coincide. The tool-holding device has at least a driver device and a clamping device that is movable relative to the driver device. To transfer a driving force to the tool device, the driver device has at least one torque transfer region that is arranged at a distance from the output axis. The driver device and the clamping device are configured to reach through a cut-out of the tool device, which cut-out extends through the entire material thickness of the tool device, and to clamp the tool device via the clamping device, which is movable substantially in a direction radial to the output axis.

Abstract: The present invention discloses a conjugate comprising an antigen (for example a saccharide antigen) covalently linked to a Pseudomonas aeruginosa PcrV carrier protein comprising an amino acid sequence which is at least 80% identical to the sequence of SEQ ID NO:1-4, wherein the antigen is linked (either directly or through a linker) to an amino acid residue of the P. aeruginosa PcrV carrier protein. The invention also discloses Pseudomonas aeruginosa PcrV proteins that contain glycosylation site consensus sequences.

Abstract: A tool device for a hand-held power tool, which can be operated such that the tool device is rotated about an output shaft of a tool-holding device, has at least one connecting device, which is detachably connected to an output shaft of the power tool. The connecting device is fastened to the tool-holding device so that a drive axis of the output shaft and a tool axis of rotation substantially coincide. The connecting device has a cut-out and at least one clamping wing, which at least partly bounds the cut-out in the radial direction of the tool axis of rotation and which is bounded substantially in the direction radial to the tool axis of rotation by a first bounding edge, which lies on a first bounding circle around the tool axis of rotation. The clamping wing extends at least substantially along a plane orthogonal to the tool axis of rotation.

Abstract: A grinding-means device, in particular a grinding-disc device or backup-pad device, for arranging at least one grinding means, in particular at least one grinding wheel, on a portable power tool, in particular a grinding machine, includes at least one receiving unit, in particular a grinding disc or backup pad, which is fixable in a thread-free manner on an output unit of the tool and on which at least one grinding means is arranged. The grinding-means device includes at least one securing unit formed separately from the receiving unit and configured to axially fix the receiving unit and/or the grinding means to the output unit of the tool in a tool-free manner, and/or at least to axially fix the grinding means to the receiving unit in a tool-free manner.

Abstract: The present invention relates to the field of modified proteins, immunogenic compositions and vaccines comprising the modified proteins, their manufacture and the use of such compositions in medicine. More particularly, it relates to a modified EPA (Exotoxin A of Pseudomonas aeruginosa) protein. The modified EPA can be used as a carrier protein for other antigens, particularly saccharide antigens or other antigens lacking T cell epitopes.

Abstract: The present disclosure provides mutated PglB oligosaccharyltransferase enzymes that have the ability to efficiently catalyze the transfer of a saccharide from a lipid carrier to an asparagine reissue in a glycosylation motif on a protein. Also provided are polynucleotides encoding the mutated PglB oligosaccharyltransferase enzymes, host cells capable of expressing the engineered PglB oligosaccharyltransferase enzymes, and methods of using the engineered PglB oligosaccharyltransferase enzymes to make N-glycosylated proteins. Also provided are N-glycosylated proteins that are made using the engineered PglB oligosaccharyltransferase enzymes.

Abstract: The present invention discloses a conjugate comprising an antigen (for example a saccharide antigen) covalently linked to a Pseudomonas aeruginosa PcrV carrier protein comprising an amino acid sequence which is at least 80% identical to the sequence of SEQ ID NO:1-4, wherein the antigen is linked (either directly or through a linker) to an amino acid residue of the P. aeruginosa PcrV carrier protein. The invention also discloses Pseudomonas aeruginosa PcrV proteins that contain glycosylation site consensus sequences.

Abstract: A tool device for a hand-held power tool, which can be operated such that the tool device is rotated about an output shaft of a tool-holding device, has at least one connecting device, which is detachably connected to an output shaft of the power tool. The connecting device is fastened to the tool-holding device so that a drive axis of the output shaft and a tool axis of rotation substantially coincide. The connecting device has a cut-out and at least one clamping wing, which at least partly bounds the cut-out in the radial direction of the tool axis of rotation and which is bounded substantially in the direction radial to the tool axis of rotation by a first bounding edge, which lies on a first bounding circle around the tool axis of rotation. The clamping wing extends at least substantially along a plane orthogonal to the tool axis of rotation.

Abstract: A tool device for a hand-held power tool, which can be operated such that the tool device is rotated about an output shaft of a tool-holding device, has at least one connecting device, which is detachably connected to an output shaft of the power tool. The connecting device is fastened to the tool-holding device so that a drive axis of the output shaft and a tool axis of rotation substantially coincide. The connecting device has a cut-out and at least one clamping wing, which at least partly bounds the cut-out in the radial direction of the tool axis of rotation and which is bounded substantially in the direction radial to the tool axis of rotation by a first bounding edge, which lies on a first bounding circle around the tool axis of rotation. The clamping wing extends at least substantially along a plane orthogonal to the tool axis of rotation.

Abstract: A grinding-means device, in particular a grinding-disc device or backup-pad device, for arranging at least one grinding means, in particular at least one grinding wheel, on a portable power tool, in particular a grinding machine, includes at least one receiving unit, in particular a grinding disc or backup pad, which is fixable in a thread-free manner on an output unit of the tool and on which at least one grinding means is arranged. The grinding-means device includes at least one securing unit formed separately from the receiving unit and configured to axially fix the receiving unit and/or the grinding means to the output unit of the tool in a tool-free manner, and/or at least to axially fix the grinding means to the receiving unit in a tool-free manner.

Abstract: A power tool, in particular a hand-held power tool, includes a tool-holding device that rotates about an output axis. The tool-holding device is configured to hold a tool device on the power tool such that the output axis and a tool rotation axis substantially coincide. The tool-holding device has at least a driver device and a clamping device that is movable relative to the driver device. To transfer a driving force to the tool device, the driver device has at least one torque transfer region that is arranged at a distance from the output axis. The driver device and the clamping device are configured to reach through a cut-out of the tool device, which cut-out extends through the entire material thickness of the tool device, and to clamp the tool device via the clamping device, which is movable substantially in a direction radial to the output axis.

Abstract: A tool device for a hand-held power tool, which can be operated such that the tool device is rotated about an output shaft of a tool-holding device, has at least one connecting device, which is detachably connected to an output shaft of the power tool. The connecting device is fastened to the tool-holding device so that a drive axis of the output shaft and a tool axis of rotation substantially coincide. The connecting device has a cut-out and at least one clamping wing, which at least partly bounds the cut-out in the radial direction of the tool axis of rotation and which is bounded substantially in the direction radial to the tool axis of rotation by a first bounding edge, which lies on a first bounding circle around the tool axis of rotation. The clamping wing extends at least substantially along a plane orthogonal to the tool axis of rotation.

Abstract: The present invention discloses a conjugate comprising an antigen (for example a saccharide antigen) covalently linked to a Pseudomonas aeruginosa PcrV carrier protein comprising an amino acid sequence which is at least 80% identical to the sequence of SEQ ID NO:1-4, wherein the antigen is linked (either directly or through a linker) to an amino acid residue of the P. aeruginosa PcrV carrier protein. The invention also discloses Pseudomonas aeruginosa PcrV proteins that contain glycosylation site consensus sequences.