Abstract: Some embodiments are directed to a visualization device for showing a patient status. The visualization device may compute an effect that a medical intervention is expected to have on the patient and generate a visualization representing a physiological parameter and the expected effect. The generated visualization may be displayed on a display.

Abstract: Provided is an apparatus (100) for transporting sweat droplets (112) to a sensor. The apparatus comprises a chamber (102) for filling with sweat. The chamber has an inlet (104) lying adjacent the surface of the skin (106), which inlet permits sweat to enter and fill the chamber. The chamber has an outlet (114) from which a sweat droplet protrudes once the chamber has been filled. The apparatus further comprises a fluid transport assembly which is designed to enable the sweat droplet protruding from the outlet to become detached from the outlet of the chamber. The sweat droplet is subsequently transported by the fluid transport assembly to the sensor. Once the protruding droplet has been released from the outlet, the outlet is made available for a subsequent sweat droplet to protrude therefrom upon further filling of the chamber.

Abstract: Provided is a system (300) for determining a sweat rate per gland and measuring biomarker concentration. The system comprises an apparatus and a sensor (166). The apparatus receives sweat from the skin and transports the sweat as discrete sweat droplets to the sensor. The sensor senses each of the counted sweat droplets. The system further comprises a processor which counts the number of sensed sweat droplets during a time period. The processor also determines time intervals between consecutive sensed sweat droplets, and receives a measure of the volume of each of the counted sweat droplets. The time intervals and the measure of the volume are then used by the processor to identify sweat burst and rest periods of the sweat gland or glands producing the sweat. This identification process necessarily involves assigning the sweat burst and rest periods to the sweat gland or glands, such that the processor is permitted to determine the number of sweat glands involved in producing the sweat.

Abstract: According to an aspect, there is provided a method comprising: receiving (402), from a sensor, first data indicative of a concentration of a first substance in sweat secreted from sweat glands of a subject; determining (404) a relationship between (i) a time of occurrence of a characteristic event in relation to the concentration of the first substance in sweat and (ii) a time of occurrence of the characteristic event in relation to the concentration of the first substance in blood; and determining (406), based on the relationship and the received first data, a time window regarding the intake of a second substance by the subject. Another aspect provides an apparatus for carrying out this method.

Abstract: A wearable patch system comprises a sensor (14) for measuring at least one sweat parameter, and a controller (16) for indicating the need to replace the patch. The controller is configured to receive the at least one sweat parameter and compare the at least one sweat parameter to a first threshold. The controller is also configured to determine the replacement information based on the total amount of time during which the at least one sweat parameter exceeds the first threshold; and/or a value indicative of the at least one sweat parameter in respect of the total amount of time during which the at least one sweat parameter exceeds the first threshold. The controller is further configured to output an indication that the wearable patch needs (12) replacing based on the replacement information.

Abstract: According to an aspect, there is provided a system (10) comprising a sweat stimulation device (100) for stimulating sweat generation from sweat glands of a subject, the device comprising: a stimulation element (102) configured to provide modulated stimulation between two non-zero states to the sweat glands through the skin of the subject; and a sensor (104) for measuring data indicative of a characteristic of sweat generated by the sweat glands in response to the stimulation; and a processor (110) configured to receive the measured data from the sensor; compare the measured data with a threshold value; and responsive to determining that the measured data meets or exceeds the threshold value, generate an alert signal.

Abstract: A patient monitoring method comprises receiving (103, 109) input data indicative of shivering episodes (52) and sweating episodes (54) of a patient; recording (105, 111) the respective points in time at which the shivering episodes and sweating episodes occur; and generating (115, 117) an output based on an alternating pattern of the shivering episodes and sweating episodes from the recorded respective points in time of the respective shivering and/or episodes. Also disclosed is a computer program product for implementing such a method and a monitoring system (10) arranged to implement such a method.

Abstract: According to an aspect, there is provided a computer-implemented method for determining an arterial blood oxygenation, SpO2, measurement for a subject. The method comprises receiving (101) a first and second photoplethysmogram, PPG, signals for the subject. The first PPG signal is obtained using a first wavelength of light and the second PPG signal is obtained using a second wavelength of light, and the first and second PPG signals comprise pulse components relating to blood volume changes in the subject over time. The method also comprises determining (103) a fundamental frequency corresponding to a pulse rate of the subject occurring during the measurement of the first and second PPG signals, and processing (105) one or more higher harmonics of the pulse components of the first and second PPG signals at frequencies higher than the fundamental frequency, excluding the fundamental frequency of the pulse components, to determine an SpO2 measurement for the subject.

Abstract: Provided is a sweat sensing device (100). The device comprises a body (102) for positioning against skin (104). A recess (108) is defined in the body for receiving sweat from a skin area. The device further comprises an optical detection assembly (114) configured to detect a discrete sweat droplet (106) protruding into the recess from a sweat pore (110) in the skin area, and a fluidic system (116) configured to transport the sweat droplet (106) away from the recess (108) following detection of the sweat droplet by the optical detection assembly (114).

Abstract: In an embodiment, a computer-implemented method (100) is described. The method comprises receiving (102) a request associated with a user for information about a client. The method further comprises, in response to the request, generating (104) information indicative of at least one interaction between at least one caregiver and a client context associated with the client based on interaction data obtained responsive to the at least one interaction. The generated information is customized to the user based on a user profile associated with the user.

Abstract: According to an aspect there is provided an apparatus (10) for calibrating a sensor (6) of a wearable device to a reference frame of a subject (50) on which the wearable device is to be worn. The wearable device comprises an ECG electrode arrangement comprising three or more ECG electrodes (9) that are in a predefined arrangement with respect to each other, and the sensor (6) has a measurement axis in a predefined orientation with respect to the ECG electrode arrangement (8).

Abstract: The present disclosure pertains to a system and method for monitoring and for facilitating pulmonary and systemic hemodynamics in the treatment and/or prevention of cardiac arrhythmias or structural cardiac changes, caused by altered preload. The system comprises: a pressure generator; a first sensor configured to generate output signals conveying information related to venous blood accumulation during cardiac preload in the subject; a second sensor configured to generate output signals conveying information related to systemic arterial circulation in the subject; and one or more hardware processors configured by machine-readable instructions to control the pressure generator to adjust the pressure levels of the flow of breathable gas during one or both of inhalation and exhalation to facilitate the pulmonary and systemic circulation based on the output signals from the first sensor and the second sensor.

Abstract: A system for unobtrusively determining a fertile window includes a contact sensor in contact with the woman and configured to provide a signal indicative of respiration of the woman. A processor is configured to process the signal to obtain a biomechanical parameter indicative of the respiration, and determine the fertile window of the woman based on a change in the obtained biomechanical parameter.

Abstract: The present invention relates to body fluid monitoring. It is proposed to incorporate a reagent-free calibration method into a patch or wearable. The method comprises capturing molecules of interest, i.e. calibration molecules inside the bioliquid of the patient, and release them when needed for calibration. This eliminates the need for onboard reagent storage. Because the calibration is done in the same bioliquid, any matrix effects are corrected for.

Abstract: According to an aspect there is provided a method of determining a calibration parameter for a first blood pressure, BP, measurement device, the method comprising obtaining a first physiological characteristic measurement of a subject using the first BP measurement device, wherein the first BP measurement device is for obtaining physiological characteristic measurements of a physiological characteristic of the subject and for determining a BP measurement of the subject from the physiological characteristic measurements using the calibration parameter, wherein the first physiological characteristic measurement is obtained when a torso of the subject is in a first posture; obtaining a second physiological characteristic measurement of the subject using the first BP measurement device, wherein the second physiological characteristic measurement is obtained when the torso of the subject is in a second, different, posture; determining the change in the posture of the torso from the first posture to the second post

Abstract: The present invention relates to biofluid monitoring. It is proposed to use a system (100) and a method to detect when a biomarker sensor (10) with a regenerable surface (14) has degraded and/or predicting when the sensor will degrade. At least one of the following methods are used for the detection: counting the number of times the surface has been regenerated, determining the cumulative amount of biomolecules measured with the device, detecting an increased/decreased voltage change or pH change needed to release the biomarkers from the capture surface, detecting deviations of the sensor raw signal signatures from factory calibration signals, and using tracer analyte molecules comprising analyte molecules bound to magnetic beads.

Abstract: The present invention relates to devices and methods for uptaking and analyzing sweat from a skin of a user. In particular, it is proposed to provide a variability in the size of the sweat sensor inlets (102, 103, 104), which can be used for improving the determination of sweat parameters like for example determining the number of active sweat glands The variability in the size of the inlets (102, 103, 104) with which the sweat sensor (100) uptakes the sweat from the user's skin (111) can be achieved by having either plurality of inlets wherein at least some of them have different opening sizes and to use the differently sized inlets based in different situations. Alternatively, one or more inlets may have openings with variable cross-sectional area, like e.g. an adjustable diameter of their opening, and also a combination of these two alternatives is of course possible.

Abstract: Provided is a method (400) of positioning a sweat sensor device (100), the method comprising: determining (410) a first skin location (i) of a mammalian subject, which first skin location (i) contains apocrine and eccrine sweat glands; determining (420) a second skin location (ii), adjacent to the first skin location (i), and having a different sweat gland composition than the first skin location, wherein at the second skin location (ii), predominantly eccrine sweat glands are present, and wherein the determining (410, 420) of the first (i) and second (it) skin locations is achieved by detecting differences between the first (i) and second (ii) skin locations; and positioning (430) the sweat sensor device (100) such that a first part of the sweat sensor device (100) is present on the first skin location (i), while a second part of the sweat sensor device (100) is present on the second skin location (ii).

Abstract: The present invention relates to a device, system and method for generating information on musculoskeletal recovery of a subject. To enable the generation of additional information on recovery of a subject to better avoid over-fatigue, injuries and overuse fractures, the device (10) comprises a sensor input (11) configured to receive a motion parameter and/or motion signal related to motion of the subject performing an activity; a processor (12) configured to determine from the motion parameter and/or motion signal a measure of impact load, determine from the measure of impact load a measure of musculoskeletal damage, and determine from the measure of impact load information on musculoskeletal recovery indicating to which extent the musculoskeletal damage recovers over time; and an output (13) configured to output the determined information on musculoskeletal recovery.

Abstract: The invention provides a physiological parameter sensing system (50) and method in which physiological information indicative of at least one physiological parameter is derived. The approach of the invention is based on constructing multiple pulse signals from different weighted combinations of at least two detection signals, derived from detected electromagnetic radiation directed onto or through a subjects skin region. The weightings are based on different of a set of various blood volume pulse vectors. A quality indication value is derived for each generated pulse signal, where this is based on a derived relationship between an obtained heart rate signal for the patient and the pulse signal. The blood volume pulse vector resulting in the pulse signal having the highest quality indicator value and/or from the derived pulse signal itself is used to derive the physiological parameter information.