Patents by Inventor Lawrence Brass

Lawrence Brass has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of using CD100 (or Sema4D) to mediate platelet activation and inflammatory responses
    Publication number: 20060147449
    Abstract: This invention relates to methods of treating platelet disorders and/or endothelial cell disorders by modulating sema4D/CD100 activity. Specifically, this invention involves the use of compounds to increase or decrease the level of soluble sema4D/CD100.
    Type: Application
    Filed: November 15, 2005
    Publication date: July 6, 2006
    Inventors: Lawrence Brass, Li Zhu
  • Method and kit for detection of thrombin receptor activation of platelets and other cells
    Patent number: 5840499
    Abstract: Method for detecting thrombin-induced cell activation via a system of detection capable of determining the presence of the cleaved peptide fragment of the thrombin receptor are provided. These methods are used in diagnosing and treating a pre-thrombotic state or thrombotic disorder in a patient. Detection kits to be used with this method are also provided.
    Type: Grant
    Filed: June 6, 1996
    Date of Patent: November 24, 1998
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Lawrence Brass, James A. Hoxie
  • Thrombine receptor activation assay for use in identifying thrombin receptor antagonists
    Patent number: 5776700
    Abstract: An assay for determining thrombin receptor activation in a cell by measuring the internalization of a labeled antibody-thrombin receptor complex following exposure to an agonist peptide is provided. This method is useful in identifying thrombin receptor antagonists.
    Type: Grant
    Filed: September 5, 1996
    Date of Patent: July 7, 1998
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Lawrence Brass, Ram Ramachandran