Patents by Inventor Lawrence Burg
Lawrence Burg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130157378Abstract: A device including a shallow chamber for analyzing a plurality of target analytes in a body fluid using the signal generated by fluorescent detector molecules each specific for a target analyte, an attenuating dye for attenuating the signal emitted by fluorescent detector molecules specifically bound to the surfaces of the chamber other than an optically clear surface, and method for determining the signal generated by each of the plurality of analytes.Type: ApplicationFiled: December 15, 2011Publication date: June 20, 2013Inventor: James Lawrence Burg
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Patent number: 8137903Abstract: A method for separating components from a patient sample is provided. In particular, the present invention provides a method for the separation of red blood cells or red blood cell components from a patient sample by the use of magnetic beads.Type: GrantFiled: December 16, 2008Date of Patent: March 20, 2012Assignee: Cytyc CorporationInventors: Howie Kaufman, Lawrence Burg
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Publication number: 20110104778Abstract: A method for separating components from a patient sample is provided. In particular, the present invention provides a method for the separation of red blood cells or red blood cell components from a patient sample by the use of magnetic beads.Type: ApplicationFiled: December 16, 2008Publication date: May 5, 2011Inventors: Howie Kaufman, Lawrence Burg
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Patent number: 7670779Abstract: The present invention relates to modification of amplification buffer used in amplification reactions. The modifications result in a significant improvement in results of amplification. In particular, the present invention provides methods and buffers for performing an amplification reaction utilizing a buffer comprising nucleotide triphosphates comprising treating the buffer to substitute a portion of the nucleotide triphosphates with nucleotide diphosphates.Type: GrantFiled: February 11, 2008Date of Patent: March 2, 2010Assignee: bioMerieux, Inc.Inventors: Brian Washburn, Douglas Lovern, Hwa-Tang Thomas Wang, Lawrence Burg
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Publication number: 20080248480Abstract: The present invention relates to modification of amplification buffer used in amplification reactions. The modifications result in a significant improvement in results of amplification. In particular, the present invention provides methods and buffers for performing an amplification reaction utilizing a buffer comprising nucleotide triphosphates comprising treating the buffer to substitute a portion of the nucleotide triphosphates with nucleotide diphosphates.Type: ApplicationFiled: February 11, 2008Publication date: October 9, 2008Inventors: Brian Washburn, Douglas Lovern, Hwa-Tang Thomas Wang, Lawrence Burg
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Publication number: 20080240985Abstract: The present invention relates to the detection of specific nucleic acid sequences, either by a process of amplification of specific nucleic acid sequences or not. More particularly the invention provides for improved compositions and methods for reducing the chance for contamination from manipulation of reagents, internal controls for amplification, and the use of automated apparatus for the automated detection of one, or more than one amplified nucleic acid sequences.Type: ApplicationFiled: July 19, 2007Publication date: October 2, 2008Inventors: Luigi Catanzariti, Bryan W. Kluttz, Marcela Vera-Garcia, J. Lawrence Burg, James G. Moe, Geoff A. McKinley
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Patent number: 7364854Abstract: The present invention relates to modification of amplification buffer used in amplification reactions. The modifications result in a significant improvement in results of amplification In particular, the present invention provides methods and buffers for performing an amplification reaction utilizing a buffer comprising nucleotide triphosphates comprising treating the buffer to substitute a portion of the nucleotide triphosphates with nucleotide diphosphates.Type: GrantFiled: January 21, 2005Date of Patent: April 29, 2008Assignee: bioMerieux, IncInventors: Brian Washburn, Douglas Lovern, Hwa-Tang Thomas Wang, Lawrence Burg
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Patent number: 7309588Abstract: The present invention relates to the detection of specific nucleic acid sequences after an amplification process, or directly without amplification. In particular, the invention provides for the automation of the amplification and detection process, the amplification and detection of one or more specific nucleic acid sequences, the use of internal controls, reduced potential for contamination caused by the manual manipulation of reagents, and improved reagent compositions to better control assay performance and provide for further protection against contamination.Type: GrantFiled: July 9, 2001Date of Patent: December 18, 2007Assignee: bioMerieux, Inc.Inventors: J. Lawrence Burg, Bryan W. Kluttz, Luigi Catanzariti, Marcela Vera-Garcia, James G. Moe, Geoff A. McKinley
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Patent number: 7262008Abstract: The present invention relates to the detection of specific nucleic acid sequences, either by a process of amplification of specific nucleic acid sequences or not. More particularly the invention provides for improved compositions and methods for reducing the chance for contamination from manipulation of reagents, internal controls for amplification, and the use of automated apparatus for the automated detection of one, or more than one amplified nucleic acid sequences.Type: GrantFiled: August 8, 2002Date of Patent: August 28, 2007Assignee: bioMerieux, Inc.Inventors: Luigi Catanzariti, Bryan W. Kluttz, Marcela Vera-Garcia, J. Lawrence Burg, James G. Moe, Geoff A. McKinley
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Publication number: 20060019266Abstract: The present invention relates to modification of amplification buffer used in amplification reactions. The modifications result in a significant improvement in results of amplification In particular, the present invention provides methods and buffers for performing an amplification reaction utilizing a buffer comprising nucleotide triphosphates comprising treating the buffer to substitute a portion of the nucleotide triphosphates with nucleotide diphosphates.Type: ApplicationFiled: January 21, 2005Publication date: January 26, 2006Inventors: Brian Washburn, Douglas Lovern, Hwa-Tang Wang, Lawrence Burg
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Publication number: 20060003343Abstract: The present invention provides selected oligonucleotides corresponding to portions of the 3? non-translating region of Hepatitis C virus. The invention also includes methods of detecting and of quantitating HCV nucleic acids in a sample using these oligonucleotides.Type: ApplicationFiled: January 21, 2005Publication date: January 5, 2006Inventors: Hwa-Tang Wang, Brian Washburn, Prakash Purohit, Lawrence Burg
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Publication number: 20040248087Abstract: The present invention relates to the detection of specific nucleic acid sequences after an amplification process, or directly without amplification. In particular, the invention provides for the automation of the amplification and detection process, the amplification and detection of one or more specific nucleic acid sequences, the use of internal controls, reduced potential for contamination caused by the manual manipulation of reagents, and improved reagent compositions to better control assay performance and provide for further protection against contamination.Type: ApplicationFiled: July 9, 2001Publication date: December 9, 2004Inventors: J. Lawrence Burg, Bryan W. Kluttz, Luigi Catanzariti, Marcela Vera-Garcia, James G. Moe, Geoff A. McKinley
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Patent number: 6586234Abstract: The present invention relates to the detection of specific nucleic acid sequences after an amplification process, or directly without amplification. In particular, the invention provides for the automation of the amplification and detection process, the amplification and detection of one or more specific nucleic acid sequences, the use of internal controls, reduced potential for contamination caused by the manual manipulation of reagents, and improved reagent compositions to better control assay performance and provide for further protection against contamination.Type: GrantFiled: February 5, 1999Date of Patent: July 1, 2003Assignee: bioMerieux Vitek, Inc.Inventors: J. Lawrence Burg, Luigi Catanzariti, Marcela Vera-Garcia, James G. Moe
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Patent number: 6558901Abstract: The present invention relates to the detection of specific nucleic acid sequences, either by a process of amplification of specific nucleic acid sequences or not. More particularly the invention provides for improved compositions and methods for reducing the chance for contamination from manipulation of reagents, internal controls for amplification, and the use of automated apparatus for the automated detection of one, or more than one amplified nucleic acid sequences.Type: GrantFiled: April 24, 1998Date of Patent: May 6, 2003Assignee: bioMerieux VitekInventors: Luigi Catanzariti, Bryan W. Kluttz, Marcela Vera-Garcia, J. Lawrence Burg, James G. Moe, Geoff A. McKinley
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Publication number: 20030077580Abstract: The present invention relates to the detection of specific nucleic acid sequences, either by a process of amplification of specific nucleic acid sequences or not. More particularly the invention provides for improved compositions and methods for reducing the chance for contamination from manipulation of reagents, internal controls for amplification, and the use of automated apparatus for the automated detection of one, or more than one amplified nucleic acid sequences.Type: ApplicationFiled: August 8, 2002Publication date: April 24, 2003Applicant: bioMerieux VitekInventors: Luigi Catanzariti, Bryan W. Kluttz, Marcela Vera-Garcia, J. Lawrence Burg, James G. Moe, Geoff A. McKinley
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Patent number: 6528632Abstract: The present invention relates to the detection of specific nucleic acid sequences after an amplification process, or directly without amplification. In particular, the invention provides for the automation of the amplification and detection process, the amplification and detection of one or more specific nucleic acid sequences, the use of internal controls, reduced potential for contamination caused by the manual manipulation of reagents, and improved reagent compositions to better control assay performance and provide for further protection against contamination.Type: GrantFiled: May 31, 2000Date of Patent: March 4, 2003Assignee: bioMerieux VitekInventors: Luigi Catanzariti, Bryan W. Kluttz, Marcela Vera-Garcia, J. Lawrence Burg, James G. Moe, Geoff A. McKinley
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Patent number: 6410276Abstract: A method is provided for multiplying the number of copies of a target polynucleotide sequence comprising a series of primer hybridization, extending, and denaturing steps to provide an intermediate double-stranded DNA molecule containing a promoter sequence (through the use of a promoter-sequence-containing primer) incorporated upstream from the target sequence. The double-stranded DNA intermediate is then used to grow multiple RNA copies of the target sequence. The resulting RNA copies can be used as target sequences to produce further copies. Multiple cycles of this sort can thereby exponentially increase the number of target sequence copies.Type: GrantFiled: April 24, 1995Date of Patent: June 25, 2002Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: James Lawrence Burg, Philippe Jacques Pouletty, John Charles Boothroyd
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Patent number: 6410275Abstract: A unit dose test device for a nucleic acid amplification reaction has the form of a elongate disposable test strip. The test strip includes a dual-chamber reaction vessel pre-loaded with nucleic acid amplification reaction reagents, and a plurality of wells for processing a reaction occurring in the reaction vessel.Type: GrantFiled: October 18, 1999Date of Patent: June 25, 2002Assignee: bioMerieux, Inc.Inventors: Bryan Kluttz, Lawrence Burg, Garry Tegeler, Louis Graziano, Christopher Cotter, Michel Guy, James Greer, Geoff McKinley, Luigi Catanzariti, Robert Glassfold, James Clement Bishop, Bruno Colin, Cécile Paris, Thomas Wang, Michael Morin
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Patent number: 6300068Abstract: The present invention relates to the detection of specific nucleic acid sequences after an amplification process, or directly without amplification. In particular, the invention provides for the automation of the amplification and detection process, the amplification and detection of one or more specific nucleic acid sequences, the use of internal controls, reduced potential for contamination caused by the manual manipulation of reagents, and improved reagent compositions to better control assay performance and provide for further protection against contamination.Type: GrantFiled: February 5, 1999Date of Patent: October 9, 2001Assignee: bioMerieux Vitek, Inc.Inventors: J. Lawrence Burg, Luigi Catanzariti, Bryan W. Kluttz, Geoff A. McKinley, James G. Moe, Marcela Vera-Garcia
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Patent number: 6090591Abstract: A method is provided for multiplying the number of copies of a target polynucleotide sequence comprising a series of primer hybridization, extending, and denaturing steps to provide an intermediate double-stranded DNA molecule containing a promoter sequence (through the use of a promoter-sequence-containing primer) incorporated upstream from the target sequence. The double-stranded DNA intermediate is then used to grow multiple RNA copies of the target sequence. The resulting RNA copies can be used as target sequences to produce further copies. Multiple cycles of this sort can thereby exponentially increase the number of target sequence copies.Type: GrantFiled: June 6, 1995Date of Patent: July 18, 2000Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: James Lawrence Burg, Philippe Jacques Pouletty, John Charles Boothroyd