Abstract: The disclosure provides methods for the acute treatment of depression and/or anxiety, for the enhancement of mTOR (e.g., mTORC1) signaling, and for the reduction of neuroinflammation, comprising administering to a patient in need thereof, a therapeutically effective amount of a 5-HT2A or 5-HT2A/D2 receptor ligand, e.g. lumateperone.

Abstract: The present invention relates to use of particular substituted heterocycle fused gamma-carbolines as described herein, in free, pharmaceutically acceptable salt or prodrug form, and pharmaceutical composition comprising the same optionally in combination with one or more agents, for the prophylaxis or treatment of one or more disorders associated with dementia, particularly behavioral or mood disturbances (e.g., agitation/aggression), psychosis, depression and sleep disturbances among others in patients suffering from dementia.

Abstract: The disclosure provides methods, treatments and materials for enhancing the effect of an adenosine A2 receptor agonist in the treatment, mitigation or prophylaxis of a disease or condition characterized by inotropic and/or lusitropic dysfunction, and/or enhancing adenosine A2 receptor function in the treatment, mitigation or prophylaxis of a disease or condition characterized by impaired adenosine A2 receptor function, comprising administration of an effective amount of a PDE1 inhibitor to a patient in need thereof, for example a patient suffering from heart failure.

Abstract: Photocurable compositions that have a color change during curing and methods of preparation and use of such compositions. More particularly, the present invention relates to photocurable compositions that that have a color change during curing and are useful for forming topographical features, e.g., spacer features, and/or fold protection coatings on a portion of a membrane surfaces, and particularly on membranes used in osmosis and reverse-osmosis applications, such as membrane filters.

Abstract: A cargo bicycle having at least a frame, rear wheel, and rear carrier rack, comprising a rear safety cage, pair of footboards and passenger cabin having a canopy and box is provided. The rear safety cage is mounted to the frame. The passenger cabin is mounted to the rear safety cage, rear carrier rack and pair of footboards and forms an interior passenger space for accommodating passengers and protecting passengers from natural or human-made environmental elements. The canopy forms an upper interior space. The box forms a lower interior space and a pair of lower interior side spaces extending outwardly from the lower interior space, straddling the rear wheel. Each of the pair of lower interior side spaces is a self-contained vessel, further protecting lower extremities of passengers from components of the cargo bicycle and debris during operation of the cargo bicycle.

Abstract: The bicycle which includes a rear wheel and a frame is disclosed. The frame includes a frame main body and two first supporting platforms. The frame main body includes two supporting parts, a bottom frame and a surrounding part. The two supporting parts are respectively located on the two sides of the rear wheel. The bottom frame is located in front of the rear wheel. The surrounding part is located in back of the rear wheel. The two first supporting platforms are respectively located on the two sides of the rear wheel. Each of the two first supporting platforms includes a side plate and a top plate. The side plate includes a front connecting end and a back connecting end.

Abstract: The bicycle which includes a rear wheel and a frame is disclosed. The frame includes a frame main body and two first supporting platforms. The frame main body includes two supporting parts, a bottom frame and a surrounding part. The two supporting parts are respectively located on the two sides of the rear wheel. The bottom frame is located in front of the rear wheel. The surrounding part is located in back of the rear wheel. The two first supporting platforms are respectively located on the two sides of the rear wheel. Each of the two first supporting platforms includes a side plate and a top plate. The side plate includes a front connecting end and a back connecting end.

Abstract: Readers are associated with a number of access credentials and, once authenticated by the reader, may grant the holder of the access credential access to a secured asset. Readers may become the target of attack, such as when an unauthorized party attempts to gain access to the interior of the reader or removes the reader from an installed location. Once removed the reader may be reinstalled in another location or a counterfeit reader used in its place. By providing a paired tamper credential, the reader may deny otherwise authorized access to the secured asset if the tamper credential fails to respond appropriately. The tamper credential may fail to respond due to distance, such as when the reader alone is relocated, or the tamper credential is damaged, such as during an attempt to gain access the interior of the reader and/or remove the reader from its installed location.

Abstract: The present invention is directed toward an RFID device that includes a motion sensing mechanism. The motion sensing mechanism is adapted to sense motion of the RFID device and then selectively allow or restrict the RFID device's ability to transmit messages, which may include sensitive data, when the RFID device is placed in an RF field. Thus, the motion sensing mechanism is utilized to control access to data on the RFID device to only instances when the holder of the RFID device moves the RFID device in a predefined sequence of motion(s).

Abstract: Methods, devices, and systems are provided for retrofitting an existing access control system with one or more supplemental access devices that add access control capabilities to the existing system. A supplemental access device can be configured as a retrofit keypad. The retrofit keypad adds the ability for a user to provide additional credential and/or security information to an access control system via one or more interface keys on the retrofit keypad. The retrofit keypad may be a portable device such as an RFID device, wireless communication device, near field communication (NFC) device, etc., and/or combinations thereof.

Abstract: The present invention is directed toward an RFID device that includes a motion sensing mechanism. The motion sensing mechanism is adapted to sense motion of the RFID device and then selectively allow or restrict the RFID device's ability to transmit messages, which may include sensitive data, when the RFID device is placed in an RF field. Thus, the motion sensing mechanism is utilized to control access to data on the RFID device to only instances when the holder of the RFID device moves the RFID device in a predefined sequence of motion(s).

Abstract: A method and device for protecting sensitive information stored on a mobile device capable of wireless communication is described. The protection is provided by permitting wireless transmission of the sensitive information only if data received from an optical sensor or a magnetic sensor satisfies a predetermined requirement.

Abstract: Method and devices for making access decisions in a secure access network are provided. The access decisions are made by one or more portable credentials using data and algorithms stored on or received by two or more credentials. Since access decisions are made by the portable credential or credentials, non-networked hosts or local hosts can be employed that do not necessarily need to be connected to a central access controller or database, thereby reducing the cost of building and maintaining the secure access network.

Abstract: Methods, systems, and devices for managing energy consumption in multi-room facilities are provided. In particular, intelligent mechanisms for determining a location of a mobile device (124) associated with a room (112a, 112b . . . 112n) and then for managing energy settings, especially setback controls, of that room (112a, 112b . . . 112n) are provided. Some logic for implementing these mechanisms may be provided in a mobile device (124) and in-room device, such as a motion detector, thermostat, HVAC controller, door, lock, television, set top box, etc.

Abstract: Readers are associated with a number of access credentials and, once authenticated by the reader, may grant the holder of the access credential access to a secured asset. Readers may become the target of attack, such as when an unauthorized party attempts to gain access to the interior of the reader or removes the reader from an installed location. Once removed the reader may be reinstalled in another location or a counterfeit reader used in its place. By providing a paired tamper credential, the reader may deny otherwise authorized access to the secured asset if the tamper credential fails to respond appropriately. The tamper credential may fail to respond due to distance, such as when the reader alone is relocated, or the tamper credential is damaged, such as during an attempt to gain access the interior of the reader and/or remove the reader from its installed location.

Abstract: The present invention is directed toward an RFID device that includes a motion sensing mechanism. The motion sensing mechanism is adapted to sense motion of the RFID device and then selectively allow or restrict the RFID device's ability to transmit messages, which may include sensitive data, when the RFID device is placed in an RF field. Thus, the motion sensing mechanism is utilized to control access to data on the RFID device to only instances when the holder of the RFID device moves the RFID device in a predefined sequence of motion(s).

Abstract: Methods, systems, and devices for updating access permissions of users in an access control system are described. The access permissions are capable of being updated based on rules and thresholds that include as at least one variable presence or contextual information associated with a user. The presence or contextual information associated with a user may be analyzed to trigger a credential update process for that user or other users within the access control system.

Abstract: Methods, systems and devices for employing the Near Field Communications (NFC) protocol are described. Specifically, a safe or similar in-room security device is configured to exchange communications with one or more NFC-enabled devices in accordance with the NFC protocol. Based on the exchange of information with the NFC-enabled devices, the safe is configured to make one or more access control decisions.

Abstract: The present invention is directed toward a communication device in communication with a motion sensing mechanism or other utility. The motion sensing mechanism or other utility is adapted to provide data to the communication device. The data is used to selectively allow or restrict the communication device's ability to transmit messages, which may include sensitive data, to a second electronic device. Thus, the motion sensing mechanism or other utility is utilized to limit access to data on the communication device to only instances when the utility provides the communication device with a recognized data input.