Patents by Inventor Lawrence G. Hamel
Lawrence G. Hamel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9144549Abstract: Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.Type: GrantFiled: March 13, 2013Date of Patent: September 29, 2015Assignee: ALZA CORPORATIONInventors: Suneel K. Gupta, Diane R Guinta, Carol A. Christopher, Samuel R. Saks, Lawrence G. Hamel
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Patent number: 9029416Abstract: Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.Type: GrantFiled: August 12, 2003Date of Patent: May 12, 2015Assignee: Alza CorporationInventors: Andrew C. Lam, Padmaja Shivanand, Atul D. Ayer, Zahedeh Hatamkhany, Suneel K. Gupta, Diane R. Guinta, Carol A. Christopher, Samuel R. Saks, Lawrence G. Hamel, Jeri D. Wright, Richard G. Weyers
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Publication number: 20150125493Abstract: Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.Type: ApplicationFiled: March 13, 2013Publication date: May 7, 2015Applicant: ALZA CORPORATIONInventors: SUNEEL K. GUPTA, DIANE R. GUINTA, CAROL A. CHRISTOPHER, SAMUEL R. SAKS, LAWRENCE G. HAMEL
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Patent number: 9000038Abstract: Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.Type: GrantFiled: March 13, 2013Date of Patent: April 7, 2015Assignee: ALZA CorporationInventors: Andrew C. Lam, Padmaja Shivanand, Atul D Ayer, Zahedeh Hatamkhany, Richard G Weyers, Suneel K. Gupta, Diane R Guinta, Carol A. Christopher, Samuel R. Saks, Lawrence G. Hamel, Jeri D. Wright
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Publication number: 20140044782Abstract: Sustained release dosage forms for twice daily oral dosing to a human patient for providing relief from pain are provided. The sustained release dosage form comprises an immediate release component and a sustained release component, wherein the immediate release component and the sustained release component collectively contain a therapeutically effective amount of an opioid analgesic and a therapeutically effective amount of nonopioid analgesic. In a preferred embodiment, the nonopioid analgesic is acetaminophen and the opioid analgesic is hydrocodone and pharmaceutically acceptable salts thereof, and in preferred embodiments, the pharmaceutically acceptable salt is bitartrate. The dosage forms produce plasma profiles in a patient characterized by a Cmax for hydrocodone of between about 0.6 ng/mL/mg to about 1.4 ng/mL/mg and an AUC for hydrocodone of between about 9.1 ng*hr/mL/mg to about 19.9 ng*hr/mL/mg (per mg hydrocodone bitartrate administered) and a Cmax for acetaminophen of between about 2.Type: ApplicationFiled: October 21, 2013Publication date: February 13, 2014Applicant: ALZA CORPORATIONInventors: Evangeline Cruz, Atul D. Ayer, Brenda J. Pollock, Carmelita Garcia, Sherry Li, Alfredo M. Wong, Lawrence G. Hamel, Cheri Enders Klein, Yihong Qiu, Ye Huang
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Patent number: 8629179Abstract: Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.Type: GrantFiled: October 19, 2009Date of Patent: January 14, 2014Assignee: Alza CorporationInventors: Suneel K. Gupta, Diane R. Guinta, Carol A. Christopher, Samuel R. Saks, Lawrence G. Hamel
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Publication number: 20120251590Abstract: Sustained release dosage forms for twice daily oral dosing to a human patient for providing relief from pain are provided. The sustained release dosage form comprises an immediate release component and a sustained release component, wherein the immediate release component and the sustained release component collectively contain a therapeutically effective amount of an opioid analgesic and a therapeutically effective amount of nonopioid analgesic.Type: ApplicationFiled: March 30, 2012Publication date: October 4, 2012Inventors: Evangeline Cruz, Atul D. Ayer, Brenda J. Pollock, Carmelita Garcia, Sherry Li, Alfredo M. Wong, Lawrence G. Hamel, Cheri Enders Klein, Yihong Qiu, Ye Huang
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Publication number: 20120165358Abstract: Sustained release dosage forms for twice daily oral dosing to a human patient for providing relief from pain are provided. The sustained release dosage form comprises an immediate release component and a sustained release component, wherein the immediate release component and the sustained release component collectively contain a therapeutically effective amount of an opioid analgesic and a therapeutically effective amount of nonopioid analgesic. In a preferred embodiment, the nonopioid analgesic is acetaminophen and the opioid analgesic is hydrocodone and pharmaceutically acceptable salts thereof, and in preferred embodiments, the pharmaceutically acceptable salt is bitartrate. The dosage forms produce plasma profiles in a patient characterized by a Cmax for hydrocodone of between about 0.6 ng/mL/mg to about 1.4 ng/mL/mg and an AUC for hydrocodone of between about 9.1 ng*hr/mL/mg to about 19.9 ng*hr/mL/mg (per mg hydrocodone bitartrate administered) and a Cmax for acetaminophen of between about 2.Type: ApplicationFiled: November 18, 2011Publication date: June 28, 2012Inventors: Evangeline Cruz, Atul D. Ayer, Brenda J. Pollock, Carmelita Garcia, Sherry Li, Alfredo M. Wong, Lawrence G. Hamel, Cheri Enders Klein, Yihong Qiu, Ye Huang
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Patent number: 8163798Abstract: Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.Type: GrantFiled: August 12, 2003Date of Patent: April 24, 2012Assignee: Alza CorporationInventors: Suneel K. Gupta, Diane R. Guinta, Carol A. Christopher, Samuel R. Saks, Lawrence G. Hamel
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Publication number: 20100221293Abstract: Sustained release dosage forms for twice daily oral dosing to a human patient for providing relief from pain are provided. The sustained release dosage form comprises an immediate release component and a sustained release component, wherein the immediate release component and the sustained release component collectively contain a therapeutically effective amount of an opioid analgesic and a therapeutically effective amount of nonopioid analgesic. In a preferred embodiment, the nonopioid analgesic is acetaminophen and the opioid analgesic is hydrocodone and pharmaceutically acceptable salts thereof, and in preferred embodiments, the pharmaceutically acceptable salt is bitartrate. The dosage forms produce plasma profiles in a patient characterized by a Cmax for hydrocodone of between about 0.6 ng/mL/mg to about 1.4 ng/mL/mg and an AUC for hydrocodone of between about 9.1 ng*hr/mL/mg to about 19.9 ng*hr/mL/mg (per mg hydrocodone bitartrate administered) and a Cmax for acetaminophen of between about 2.Type: ApplicationFiled: March 2, 2010Publication date: September 2, 2010Inventors: Evangeline Cruz, Atul D. Ayer, Brenda J. Pollock, Carmelita Garcia, Sherry Li, Alfredo M. Wong, Lawrence G. Hamel, Cheri Enders Klein, Yihong Qiu, Ye Huang
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Publication number: 20100196425Abstract: A sustained release dosage form is provided comprising a pharmaceutically active agent and pharmaceutically acceptable salts thereof and adapted to release as an erodible solid over a prolonged period of time, wherein the dosage form provides burst release of the pharmaceutically active agent without the use of an immediate release drug coating. The dosage form is able to deliver high doses of poorly soluble or slowly dissolving active agents at a controlled rate. Methods of using the dosage forms to treat disease or conditions in human patients are also disclosed.Type: ApplicationFiled: January 6, 2010Publication date: August 5, 2010Inventors: Evangeline Cruz, Sherry Li, Atul D. Ayer, Brenda J. Pollock, Gregory C. Ruhlmann, Carmelita Garcia, Alfredo M. Wong, Lawrence G. Hamel
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Publication number: 20100093796Abstract: Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.Type: ApplicationFiled: October 19, 2009Publication date: April 15, 2010Inventors: Suneel K. Gupta, Diane R. Guinta, Carol A. Christopher, Samuel R. Saks, Lawrence G. Hamel
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Patent number: 6930129Abstract: Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.Type: GrantFiled: March 8, 2001Date of Patent: August 16, 2005Assignee: Alza CorporationInventors: Andrew C. Lam, Padmaja Shivanand, Atul D. Ayer, Zahedeh Hatamkhany, Suneel K. Gupta, Diane R. Guinta, Carol A. Christopher, Samuel R. Saks, Lawrence G. Hamel, Jeri D. Wright, Richard G. Weyers
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Patent number: 6919373Abstract: Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.Type: GrantFiled: February 19, 1999Date of Patent: July 19, 2005Assignee: Alza CorporationInventors: Andrew C. Lam, Padmaja Shivanand, Atul D. Ayer, Richard G. Weyers, Suneel K. Gupta, Diane R. Guinta, Carol A. Christopher, Samuel R. Saks, Lawrence G. Hamel, Jeri D. Wright, Zahedeh Hatamkhany
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Patent number: 6534089Abstract: The invention disclosed pertains to a novel delivery system comprising an agent formulation and means for dispensing the agent formulation from the delivery system.Type: GrantFiled: June 23, 2000Date of Patent: March 18, 2003Assignee: Alza CorporationInventors: Atul D. Ayer, Andrew Lam, Judy A. Magruder, Lawrence G. Hamel, Patrick S. L. Wong
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Publication number: 20020114838Abstract: The invention disclosed pertains to a novel delivery system comprising an agent formulation and means for dispensing the agent formulation from the delivery system.Type: ApplicationFiled: November 7, 2001Publication date: August 22, 2002Inventors: Atul D. Ayer, Andrew Lam, Judy A. Magruder, Lawrence G. Hamel, Patrick S. L. Wong
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Publication number: 20010012847Abstract: Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.Type: ApplicationFiled: March 8, 2001Publication date: August 9, 2001Inventors: Andrew C. Lam, Padmaja Shivanand, Atul D. Ayer, Zahedeh Hatamkhany, Suneel K. Gupta, Diane R. Guinta, Carol A. Christopher, Samuel R. Saks, Lawrence G. Hamel, Jeri D. Wright, Richard G. Weyers
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Patent number: 6096339Abstract: The invention disclosed pertains to a dosage form comprising an agent formulation comprising drug and pharmaceutical carrier of cooperating particle size and means for dispensing the agent formulation from the dosage form.Type: GrantFiled: April 4, 1997Date of Patent: August 1, 2000Assignee: ALZA CorporationInventors: Atul D. Ayer, Andrew Lam, Judy A. Magruder, Lawrence G. Hamel, Patrick S. L. Wong
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Patent number: 5800422Abstract: The present invention is directed to a fluid-imbibing drug delivery device which is useful for the initial delayed delivery of an active agent formulation to a fluid environment of use, the initial delay period to startup or activation of the device being of a predetermined length of time. The delivery of the agent formulation from the dispensing device is continued until essentially all of the active agent formulation is delivered as a result of the expansion of an expansion agent in the active agent delivery chamber.Type: GrantFiled: August 8, 1996Date of Patent: September 1, 1998Assignee: Alza CorporationInventors: Liang C. Dong, Patrick S.-L. Wong, Si-Hong A. Yum, Lawrence G. Hamel, Michael H. Dealey
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Patent number: 5178867Abstract: The invention pertains to a dosage form for orally administering a drug in eight hours or less to the stomach and small intestine for a therapeutic result.Type: GrantFiled: August 19, 1991Date of Patent: January 12, 1993Assignee: Alza CorporationInventors: George V. Guittard, Howard A. Carpenter, Ernest S. Quan, Patrick S. Wong, Lawrence G. Hamel