Abstract: In general, the invention relates to pharmaceutical compositions comprising (R)-oxybutynin and a norepinephrine reuptake inhibitor (NRI) and methods of treating Sleep Apnea comprising administering (R)-oxybutynin and a norepinephrine reuptake inhibitor (NRI). In some embodiments, the NRI is atomoxetine.

Abstract: Pharmaceutical compositions comprising reboxetine or a pharmaceutically acceptable salt thereof and a muscarinic receptor antagonist (MRA) and methods of treating sleep apnea comprising administering reboxetine or a pharmaceutically acceptable salt thereof and an MRA are described herein. In some embodiments, the MRA is oxybutynin or (R)-oxybutynin or a pharmaceutically acceptable salt thereof.

Abstract: Pharmaceutical compositions comprising Lemborexant or a pharmaceutically acceptable salt thereof and a norepinephrine reuptake inhibitor (NRI) and methods of treating Sleep Apnea comprising administering Lemborexant or a pharmaceutically acceptable salt thereof and an NRI are described herein. In some embodiments, the NRI is atomoxetine or a pharmaceutically acceptable salt thereof. In some embodiments, the pharmaceutical compositions further comprise a muscarinic receptor antagonist (MRA). In some embodiments, the methods of treating Sleep Apnea further comprise administering an MRA. In some embodiments, the MRA is oxybutynin or a pharmaceutically acceptable salt thereof.

Abstract: In general, the invention relates to pharmaceutical compositions comprising (R)-oxybutynin and a norepinephrine reuptake inhibitor (NRI) and methods of treating Sleep Apnea comprising administering (R)-oxybutynin and a norepinephrine reuptake inhibitor (NRI). In some embodiments, the NRI is atomoxetine.

Abstract: In general, the invention relates to pharmaceutical compositions comprising a thyrotropin-releasing hormone (TRH) analog, and methods of treating sleep apnea comprising administering a TRH analog.

Abstract: In general, the invention relates to pharmaceutical compositions comprising (R)-oxybutynin and a norepinephrine reuptake inhibitor (NRI) and methods of treating Sleep Apnea comprising administering (R)-oxybutynin and a norepinephrine reuptake inhibitor (NRI). In some embodiments, the NRI is atomoxetine.

Abstract: In general, the invention relates to pharmaceutical compositions comprising a norepinephrine reuptake inhibitor (NRI), muscarinic receptor antagonist, and carbonic anhydrase inhibitor and methods of treating Sleep Apnea comprising the administration of these pharmaceutical compositions.

Abstract: In general, the invention relates to pharmaceutical compositions comprising 4-hydroxyatomoxetine used with a muscarinic receptor antagonist, and methods of treating sleep apnea comprising administering a muscarinic receptor antagonist and 4-hydroxyatomoxetine. The 4-hydroxyatomoxetine and muscarinic receptor antagonist are disposed in a pharmaceutically acceptable carrier.

Abstract: In general, the invention relates to pharmaceutical compositions comprising (R)-oxybutynin and a norepinephrine reuptake inhibitor (NRI) and methods of treating Sleep Apnea comprising administering (R)-oxybutynin and a norepinephrine reuptake inhibitor (NRI). In some embodiments, the NRI is atomoxetine.

Abstract: A polymeric-resin-coated papermaking-processing belt, which may be used as a sheet-transfer, long nip press (LNP) or calender belt, includes a reinforcing base having the form of an endless loop with a face side and a back side, these being the outside and inside of the endless loop, respectively. The face side of the reinforcing base is coated with a polymeric resin material, while the back side has a staple fiber batt attached thereto. The staple fiber batt has a smooth, fused surface free of protruding fiber ends. This surface is kept clean more easily than that of a typical staple fiber batt. Methods for manufacturing the polymeric-resin-coated papermaking-processing belt, including several ways for providing the staple fiber batt with the smooth, fused surface, are also disclosed.

Abstract: A coater belt for carrying and supporting a web through a coating station on a paper or board machine, or an off-line coater, said belt comprising an endless base member and at least a first surface layer. Said surface layer is an impermeable coating comprising a first material and a particulate filler material. The filler material which are present in the web-contact surface provide a well-defined roughness on micro-scale of said web-contact surface. The web-contact surface further presents a well-defined surface energy for accomplishing an adhesion to the web for picking-up the web at an entrance side of the coating station and for holding the web against the coater belt during its path through the coating station.

Abstract: Methods for closing a seam in a paper processing belt having a coating of polymeric resin material require the covering of the seam on the uncoated side of the belt with an encapsulating material, so that the seam will have compression properties substantially identical to those of use of the remainder of the belt. In one method, a viscous paste obtained by mixing a polymeric resin material with a blowing agent is used. Following installation of the fabric, or belt, on a paper machine by closing its pin seam with a pintle, the seam region on the non-paper side of the fabric or belt is impregnated with the viscous paste. The seam region is then heated to a temperature to activate the blowing agent and to create a foam from the paste. The foam fills voids in the seam region, and may pass out through the slit in the coating over the seam. Raising the temperature further cures the foam and may glue the slit closed.

Abstract: A method for closing a seam in a paper processing belt having a coating of polymeric resin material requires the use of a viscous paste obtained by mixing a polymeric resin material with a blowing agent. Following installation of the fabric, or belt, on a paper machine by closing its pin seam with a pintle, the seam region on the non-paper side of the fabric or belt is impregnated with the viscous paste. The seam region is then heated to a temperature to activate the blowing agent and to create a foam from the paste. The foam fills voids in the seam region, and may pass out through the slit in the coating over the seam. Raising the temperature further cures the foam and may glue the slit closed. The belt so seamed may be used as a transfer belt or long nip press (LNP) belt, or in other paper processing applications.

Abstract: An apparatus for searching and retrieving files in a database without a user being required to provide keywords or query terms. A user first selects and opens a reference file. A natural language recognition algorithm is used to determine the subject words of the selected file. Next, a statistical comparison between the subject words and the contents of files in a database is performed. Based on the statistical comparison, files are assigned weighted relevancies. Relevant files are prioritized and displayed to the user in groups. The groups are formed based on the retrieved files relevance to specific subject works of the selected file. The groups of retrieved files are displayed in associating with the subject word they are relevant to.

Abstract: A container opening device is designed for use with waxed paper board cartons of the type utilized for packaging milk, orange juice and other beverages. These cartons have an initially closed dispensing opening formed by a pair of overfolded flaps intersecting at a central apex. The present invention includes a manual grasping element secured by a cord to the central apex to facilitate opening of the carton. The manual grasping member may comprise a ring for finger insertion or a small spherical ball. The cord is secured to a reinforcement strip which may be adhesively secured to an exterior surface of the cart or sandwiched between the paper board layers forming the carton.

Abstract: A variable radar altimeter test system for providing a test of the altime portion of a flying object guidance system which simulates actual flight conditions includes an antenna connection to receive a signal from the flying object being tested, a synthesizer for generating a signal programmed to simulate data characteristic of a radar return signal, pulse modulation of the programmed signal to create a third signal which is returned to the flying object under test to stimulate the altimeter portion of its guidance system.