Patents by Inventor Lawrence Isaac Galler

Lawrence Isaac Galler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy
    Patent number: 6087332
    Abstract: Streptokinase derivatives having platelet glycoprotein binding domains adjacent to the termini of the streptokinase sequence. These derivatives produce higher local concentrations of plasmin in vivo as compared to unmodified streptokinase. Certain of the derivatives have high affinity for the GPIIB/IIIA receptor and low affinity for the fibronectin and vitronectin receptors. Others have substantially equivalent affinity for all three receptors. The derivatives are useful in treating thromboembolic disorders. The streptokinase derivatives can be made by recombinant techniques or by chemical synthesis or conjugation.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: July 11, 2000
    Inventor: Lawrence Isaac Galler