Patents by Inventor Lawrence J. Bonassar
Lawrence J. Bonassar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240024537Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.Type: ApplicationFiled: February 2, 2023Publication date: January 25, 2024Inventors: Lawrence J. BONASSAR, Roger HARTL, Robert D. BOWLES, Harry H. GEBHARD
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Patent number: 11812939Abstract: A device comprising a housing including a palm portion, a sheath portion extending from one end of the palm portion, and a slot comprising an adjustable platform capable of receiving a syringe and a needle connected to the syringe with the needle resting in the sheath portion. A trigger mechanism is connected to the adjustable platform. Adjustment of the trigger mechanism in a first direction moves the platform along the slot toward the sheath portion and adjustment of the bidirectional trigger mechanism in a second direction moves the platform away from the sheath. A light element is connected to the housing and is capable of directing light along the sheath portion away from the palm portion. A power source is electrically coupled to the light element to provide electrical power to the light element. Also disclosed is a system comprising the device, as well as methods of using the device.Type: GrantFiled: May 15, 2018Date of Patent: November 14, 2023Assignee: CORNELL UNIVERSITYInventors: Lawrence J. Bonassar, Roger Hartl, Monika McCarter, Anny Cunha-Gavidia, Michael Messina, Gayathri Shibu, Si Chen
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Patent number: 11596713Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) comprising a nucleus pulposus structure comprising a first population of living cells and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and collagen.Type: GrantFiled: November 25, 2020Date of Patent: March 7, 2023Assignee: CORNELL UNIVERSITYInventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
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Publication number: 20210213168Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.Type: ApplicationFiled: November 25, 2020Publication date: July 15, 2021Inventors: Lawrence J. BONASSAR, Roger HARTL, Robert D. BOWLES, Harry H. GEBHARD
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Publication number: 20210153854Abstract: A device comprising a housing including a palm portion, a sheath portion extending from one end of the palm portion, and a slot comprising an adjustable platform capable of receiving a syringe and a needle connected to the syringe with the needle resting in the sheath portion. A trigger mechanism is connected to the adjustable platform. Adjustment of the trigger mechanism in a first direction moves the platform along the slot toward the sheath portion and adjustment of the bidirectional trigger mechanism in a second direction moves the platform away from the sheath. A light element is connected to the housing and is capable of directing light along the sheath portion away from the palm portion. A power source is electrically coupled to the light element to provide electrical power to the light element. Also disclosed is a system comprising the device, as well as methods of using the device.Type: ApplicationFiled: May 15, 2018Publication date: May 27, 2021Inventors: Lawrence J. BONASSAR, Roger HARTL, Monika MCCARTER, Anny CUNHA-GAVIDIA, Michael MESSINA, Gayathri SHIBU, Si CHEN
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Patent number: 10874764Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.Type: GrantFiled: June 16, 2019Date of Patent: December 29, 2020Assignee: Cornell UniversityInventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
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Publication number: 20190365949Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.Type: ApplicationFiled: June 16, 2019Publication date: December 5, 2019Inventors: Lawrence J. BONASSAR, Roger HARTL, Robert D. BOWLES, Harry H. GEBHARD
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Patent number: 10363341Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.Type: GrantFiled: April 26, 2017Date of Patent: July 30, 2019Assignee: Cornell UniversityInventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
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Patent number: 10344243Abstract: This invention relates to methods of lubrication for biological tissue, especially joint and cartilage surfaces, and to methods of treating osteoarthritis using high molecular weight, hydrophilic polymer brushes, which mimic the structure and activity of lubricin. These synthetic lubricin analog polymer brushes (termed herein graft brush polymers), include poly(acrylic acid) backbones grafted with polyethylene glycol.Type: GrantFiled: October 18, 2013Date of Patent: July 9, 2019Assignee: CORNELL UNIVERSITYInventors: David Putnam, Mingchee Tan, Kirk J. Samaroo, Lawrence J. Bonassar
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Publication number: 20190194564Abstract: This invention relates to methods of lubrication for biological tissue, especially joint and cartilage surfaces, and to methods of treating osteoarthritis using high molecular weight, hydrophilic polymer brushes, which mimic the structure and activity of lubricin. These synthetic lubricin analog polymer brushes (termed herein graft brush polymers), include poly(acrylic acid) backbones grafted with polyethylene glycol.Type: ApplicationFiled: December 27, 2018Publication date: June 27, 2019Applicant: CORNELL UNIVERSITYInventors: David PUTNAM, Mingchee TAN, Kirk J. SAMAROO, Lawrence J. BONASSAR
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Publication number: 20190030210Abstract: The present invention relates to methods of determining if a tissue engineered construct is ready for implantation. In one aspect the method involves providing a tissue engineered construct comprising a scaffold having pores, analyzing the tissue engineered construct for buckling of pores, and determining whether the tissue engineered construct is ready for implantation based on the analysis. In another aspect, the invention relates to a method that involves non-destructive methods for determining whether a tissue engineered construct is ready for implantation.Type: ApplicationFiled: July 2, 2018Publication date: January 31, 2019Inventors: Jill M. Middendorf, Lawrence J. Bonassar, Lena R. Bartell, Itai Cohen
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Publication number: 20170290953Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.Type: ApplicationFiled: April 26, 2017Publication date: October 12, 2017Inventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
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Patent number: 9662420Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.Type: GrantFiled: May 12, 2015Date of Patent: May 30, 2017Assignee: Cornell UniversityInventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
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Publication number: 20150275118Abstract: This invention relates to methods of lubrication for biological tissue, especially joint and cartilage surfaces, and to methods of treating osteoarthritis using high molecular weight, hydrophilic polymer brushes, which mimic the structure and activity of lubricin. These synthetic lubricin analog polymer brushes (termed herein graft brush polymers), include poly(acrylic acid) back-bones grafted with polyethylene glycol.Type: ApplicationFiled: October 18, 2013Publication date: October 1, 2015Applicant: CORNELL UNIVERSITYInventors: David Putnam, Mingchee Tan, Kirk J. Samaroo, Lawrence J. Bonassar
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Publication number: 20150238657Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.Type: ApplicationFiled: May 12, 2015Publication date: August 27, 2015Inventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
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Patent number: 9044335Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.Type: GrantFiled: May 5, 2010Date of Patent: June 2, 2015Assignee: Cornell UniversityInventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
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Publication number: 20130079881Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.Type: ApplicationFiled: May 5, 2010Publication date: March 28, 2013Applicant: CORNELL UNIVERSITYInventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
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Publication number: 20090317448Abstract: The invention features methods of making living tissue constructs that can be used to repair perforations in tympanic membranes, the repair constructs themselves, and methods of repair.Type: ApplicationFiled: June 18, 2008Publication date: December 24, 2009Inventors: Lawrence J. Bonassar, Morgan Hott, Clifford Megerian, Richard M. Beane
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Publication number: 20090041851Abstract: The invention relates to an improved method for administering live cells to a patient and compositions useful in the method. The composition comprises live cells and biocompatible, biodegradable polymer microparticles. The cells and microparticles of the cell/microparticle composition can be contacted immediately prior to administration, or can be contacted in culture for a specified period of time prior to administration. In the method of the invention, an effective amount of the cell/microparticle composition is administered to a patient in need thereof by injection to a treatment site of the patient to provide a therapeutic effect in the patient. The therapeutic effect can be, for example, the formation of new tissue at the treatment site, or the production and secretion of a biologically active secretory molecule at the treatment site. The therapeutic effect resulting from injection of the cell/microparticle composition into a treatment site, is determined by the type of cell present in the composition.Type: ApplicationFiled: February 19, 2008Publication date: February 12, 2009Inventors: Henry R. Costantino, Lawrence J. Bonassar, Mark A. Tracy
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Publication number: 20040234547Abstract: The invention relates to an improved method for administering live cells to a patient and compositions useful in the method. The composition comprises live cells and biocompatible, biodegradable polymer microparticles. The cells and microparticles of the cell/microparticle composition can be contacted immediately prior to administration, or can be contacted in culture for a specified period of time prior to administration. In the method of the invention, an effective amount of the cell/microparticle composition is administered to a patient in need thereof by injection to a treatment site of the patient to provide a therapeutic effect in the patient. The therapeutic effect can be, for example, the formation of new tissue at the treatment site, or the production and secretion of a biologically active secretory molecule at the treatment site. The therapeutic effect resulting from injection of the cell/microparticle composition into a treatment site, is determined by the type of cell present in the composition.Type: ApplicationFiled: February 23, 2004Publication date: November 25, 2004Applicants: Alkermes Controlled Therapeutics, Inc., University of MassachusettsInventors: Henry R. Costantino, Lawrence J. Bonassar, Mark A. Tracy