Patents by Inventor Lawrence Kolaczkowski

Lawrence Kolaczkowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-((R)-2-methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide crystalline form 1
    Patent number: 9580410
    Abstract: 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide Crystalline Form 1, ways to make it, compositions comprising it and made using it, and methods of treating patients having disease using it are disclosed.
    Type: Grant
    Filed: August 12, 2014
    Date of Patent: February 28, 2017
    Assignee: AbbVie Inc.
    Inventor: Lawrence Kolaczkowski
  • 2-((R)-2-METHYLPYRROLIDIN-2-YL)-1H-BENZIMIDAZOLE-4-CARBOXAMIDE CRYSTALLINE FORM 1
    Publication number: 20150148392
    Abstract: 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide Crystalline Form 1, ways to make it, compositions comprising it and made using it, and methods of treating patients having disease using it are disclosed.
    Type: Application
    Filed: August 12, 2014
    Publication date: May 28, 2015
    Inventor: Lawrence Kolaczkowski
  • 2-((R)-2-methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide crystalline form 1
    Patent number: 8835647
    Abstract: 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide Crystalline Form 1, ways to make it, compositions comprising it and made using it, and methods of treating patients having disease using it are disclosed.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: September 16, 2014
    Assignee: AbbVie Inc.
    Inventor: Lawrence Kolaczkowski
  • 2-((R)-2-METHYLPYRROLIDIN-2-YL)-1H-BENZIMIDAZOLE-4-CARBOXAMIDE CRYSTALLINE FORM 1
    Publication number: 20140024838
    Abstract: 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide Crystalline Form 1, ways to make it, compositions comprising it and made using it, and methods of treating patients having disease using it are disclosed.
    Type: Application
    Filed: September 27, 2013
    Publication date: January 23, 2014
    Applicant: AbbVie Inc.
    Inventor: Lawrence Kolaczkowski
  • Octahydro-pyrrolo[3,4-B]pyrrole derivatives
    Patent number: 8399468
    Abstract: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.
    Type: Grant
    Filed: March 2, 2010
    Date of Patent: March 19, 2013
    Assignee: Abbott Laboratories
    Inventors: Marlon D. Cowart, Chen Zhao, Minghua Sun, Lawrence A. Black, Guo Zhu Zheng, Robert J. Gregg, Geoff G. Z. Zhang, Ahmad Y. Sheikh, Xiaochun Lou, Rodger F. Henry, David M. Barnes, Lawrence Kolaczkowski, Anthony R. Haight, Sou-Jen Chang, Steven J. Wittenberger, Michael G. Fickes
  • 2-{(R)-2-methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide crystalline form 1
    Patent number: 8372987
    Abstract: 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide Crystalline Form 1, ways to make it, compositions comprising it and made using it, and methods of treating patients having disease using it are disclosed.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: February 12, 2013
    Assignee: AbbVie Inc.
    Inventor: Lawrence Kolaczkowski
  • Retroviral protease inhibiting compounds
    Patent number: 7968707
    Abstract: A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
    Type: Grant
    Filed: February 27, 2007
    Date of Patent: June 28, 2011
    Assignee: Abbott Laboratories
    Inventors: Hing Leung Sham, Daniel W. Norbeck, Xiaoqi Chen, David A. Betebenner, Dale J. Kempf, Thomas R. Herrin, Gondi N. Kumar, Stephen L. Condon, Arthur J. Cooper, Daniel A. Dickman, Steven M. Hannick, Lawrence Kolaczkowski, Patricia A. Oliver, Daniel J. Plata, Peter J. Stengel, Eric J. Stoner, Jieh-Heh J. Tien, Jih-Hua Liu, Ketan M. Patel
  • OCTAHYDRO-PYRROLO[3,4-B]PYRROLE DERIVATIVES
    Publication number: 20100222358
    Abstract: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.
    Type: Application
    Filed: March 2, 2010
    Publication date: September 2, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Marlon D. Cowart, Chen Zhao, Minghua Sun, Lawrence A. Black, Guo Zhu Zheng, Robert J. Gregg, Geoff G.Z. Zhang, Ahmad Y. Sheikh, Xiaochun Lou, Rodger F. Henry, David M. Barnes, Lawrence Kolaczkowski, Anthony R. Haight, Sou-Jen Chang, Steven J. Wittenberger, Michael G. Fickes
  • Octahydro-pyrrolo[3,4-b]pyrrole derivatives
    Patent number: 7728031
    Abstract: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands, Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: June 1, 2010
    Assignee: Abbott Laboratories
    Inventors: Marlon D. Cowart, Chen Zhao, Minghua Sun, Lawrence A. Black, Guo Zhu Zheng, Robert J. Gregg, Lawrence Kolaczkowski
  • 2-{(R)-2-METHYLPYRROLIDIN-2-YL)-1H-BENZIMIDAZOLE-4-CARBOXAMIDE CRYSTALLINE FORM 1
    Publication number: 20090099245
    Abstract: 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide Crystalline Form 1, ways to make it, compositions comprising it and made using it, and methods of treating patients having disease using it are disclosed.
    Type: Application
    Filed: October 10, 2008
    Publication date: April 16, 2009
    Applicant: ABBOTT LABORATORIES
    Inventor: Lawrence Kolaczkowski
  • Sulfonamides having antiangiogenic and anticancer activity
    Patent number: 7491718
    Abstract: Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: February 17, 2009
    Assignee: Abbott Laboratories
    Inventors: Kenneth M. Comess, Scott A. Erickson, Jack Henkin, Douglas M. Kalvin, Megumi Kawai, Ki H. Kim, Nwe Y. BaMaung, Chang Hoon Park, George S. Sheppard, Anil Vasudevan, Jieyi Wang, David M. Barnes, Steve D. Fidanze, Lawrence Kolaczkowski, Robert A. Mantei, David C. Park, William J. Sanders, Jason S. Tedrow, Gary T. Wang
  • RETROVIRAL PROTEASE INHIBITING COMPOUNDS
    Publication number: 20080139811
    Abstract: A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
    Type: Application
    Filed: February 27, 2007
    Publication date: June 12, 2008
    Inventors: Hing Sham, Daniel Norbeck, Xiaoqi Chen, David Betebenner, Dale Kempf, Thomas Herrin, Gondi Kumar, Stephen Condon, Arthur Cooper, Daniel Dickman, Steven Hannick, Lawrence Kolaczkowski, Patricia Oliver, Daniel Plata, Peter Stengel, Eric Stoner, Jieh-Heh Tien, Jih-Hua Liu, Ketan Patel
  • Retroviral protease inhibiting compounds
    Patent number: 7279582
    Abstract: A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
    Type: Grant
    Filed: October 25, 2002
    Date of Patent: October 9, 2007
    Assignee: Abbott Laboratories
    Inventors: Eric J. Stoner, Arthur J. Cooper, Lawrence Kolaczkowski, Ketan M. Patel, Hing Leung Sham, Daniel W. Norbeck, Xiaoqi Chen, David A. Betebenner, Thomas R. Herrin, Gondi N. Kumar, Stephen L. Condon, Daniel A. Dickman, Patricia A. Oliver, Jien-Heh J. Tien
  • Octahydro-pyrrolo[3,4-b]pyrrole Derivatives
    Publication number: 20070232612
    Abstract: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands, Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.
    Type: Application
    Filed: February 13, 2007
    Publication date: October 4, 2007
    Inventors: Marlon Cowart, Chen Zhao, Minghua Sun, Lawrence Black, Guo Zheng, Robert Gregg, Geoff Zhang, Ahmand Sheikh, Xiaochun Lou, Rodger Henry, David Barnes, Lawrence Kolaczkowski, Anthony Haight, Sou-Jen Chang, Steven Wittenberger, Michael Fickes
  • Preparation of quinoline-substituted carbonate and carbamate derivatives
    Patent number: 7074932
    Abstract: The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.
    Type: Grant
    Filed: May 7, 2003
    Date of Patent: July 11, 2006
    Inventors: Michael S. Allen, Ramiya H. Premchandran, Sou-Jen Chang, Stephen Condon, John A. DeMattei, Steven A. King, Lawrence Kolaczkowski, Sukumar Manna, Paul J. Nichols, Hemant H. Patel, Subhash R. Patel, Daniel J. Plata, Eric J. Stoner, Jien-Heh J. Tien, Steven J. Wittenberger
  • Preparation of quinoline-substituted carbonate and carbamate derivatives
    Publication number: 20060128962
    Abstract: The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.
    Type: Application
    Filed: February 6, 2006
    Publication date: June 15, 2006
    Inventors: Michael Allen, Ramiya Premchandran, Sou-Jen Chang, Stephen Condon, John DeMattei, Steven King, Lawrence Kolaczkowski, Sukumar Manna, Paul Nichols, Hemant Patel, Subhash Patel, Daniel Plata, Eric Stoner, Jien-Heh Tien, Steven Wittenberger
  • Substituted pyridines having antiangiogenic activity
    Publication number: 20060030557
    Abstract: Compounds having the formula are angiogenesis inhibitors. Also disclosed are compositions containing the compounds, methods of making the compounds, and methods of treatment using the compounds.
    Type: Application
    Filed: October 6, 2005
    Publication date: February 9, 2006
    Inventors: Fortuna Haviv, Michael Bradley, Jack Henkin, Jurgen Dinges, Daryl Sauer, Lawrence Kolaczkowski, Anil Vasudevan, David Park
  • Synthesis of acyclic nucleoside derivatives
    Publication number: 20050250795
    Abstract: Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 18, 2005
    Publication date: November 10, 2005
    Applicant: Medivir AB
    Inventors: M. Leanna, Steven Hannick, Michael Rasmussen, Jien-Heh Tien, Lakshmi Bhagavatula, Pulla Singam, Bradley Gates, Lawrence Kolaczkowski, Ramesh Patel, Greg Wayne, Greg Lannoye, Weijiang Zhang, Zhenping Tian, Kirill Lukin, Bikshandarkoil Narayanan, David Riley, Howard Morton, Sou-Jen Chang, Cynthia Curty, Daniel Plata, John Bellettini, Bhadra Shelat, Tiffany Spitz, Cheng-Xi Yang
  • Synthesis of acyclic nucleoside derivatives
    Publication number: 20040248910
    Abstract: Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: 1
    Type: Application
    Filed: June 17, 2004
    Publication date: December 9, 2004
    Applicant: Medivir AB
    Inventors: M. Robert Leanna, Steven M. Hannick, Michael Rasmussen, Jien-Heh J. Tien, Lakshmi Bhagavatula, Pulla Reddy Singam, Bradley D. Gates, Lawrence Kolaczkowski, Ramesh R. Patel, Greg Wayne, Greg Lannoye, Weijiang Zhang, Zhenping Tian, Kirill A. Lukin, Bikshandarkoil A. Narayanan, David A. Riley, Howard Morton, Sou-Jen Chang, Cynthia B. Curty, Daniel Plata, John Bellettini, Bhadra Shelat, Tiffany Spitz, Cheng-Xi Yang
  • Sulfonamides having antiangiogenic and anticancer activity
    Publication number: 20040167128
    Abstract: Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
    Type: Application
    Filed: October 8, 2003
    Publication date: August 26, 2004
    Inventors: Kenneth M. Comess, Scott A. Erickson, Jack Henkin, Douglas M. Kalvin, Megumi Kawai, Ki H. Kim, Nwe Y. BaMaung, Chang Hoon Park, George S. Sheppard, Anil Vasudevan, Jieyi Wang, David M. Barnes, Steve D. Fidanze, Lawrence Kolaczkowski, Robert A. Mantei, David C. Park, William J. Sanders, Jason S. Tedrow, Gary T. Wang