Patents by Inventor Lawrence M. Kauvar

Lawrence M. Kauvar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DIAGNOSTIC MARKER FOR TREATMENT OF CEREBRAL ISCHEMIA
    Publication number: 20150258193
    Abstract: Identification of candidates for treatment and treatment of subjects experiencing cerebral ischemia wherein the treatment employs a thrombolytic or thrombectomy agent and an inhibitor of vascular endothelial growth factor (VEGF) receptor-mediated signal transduction are determined by testing the blood of a patient for total S-100B or for S-100BB as a marker of blood brain barrier integrity.
    Type: Application
    Filed: March 13, 2015
    Publication date: September 17, 2015
    Inventors: Lawrence M. KAUVAR, Damir JANIGRO
  • HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN CYTOMEGALOVIRUS (CMV) GB PROTEIN
    Publication number: 20150252099
    Abstract: Recombinant monoclonal antibodies to human cytomegalovirus (CMV) gB protein are described. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.
    Type: Application
    Filed: April 27, 2015
    Publication date: September 10, 2015
    Inventors: Lawrence M. KAUVAR, Stote ELLSWORTH, William USINGER, Krista Maureen MCCUTCHEON, Ying-Ping JIANG, Fen ZHANG, Bo CHEN, Gizette SPERINDE, Minha PARK, Orit FOORD
  • BINDING MOIETIES FOR BIOFILM REMEDIATION
    Publication number: 20150197558
    Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species and decoy nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
    Type: Application
    Filed: March 25, 2015
    Publication date: July 16, 2015
    Inventors: Lawrence M. KAUVAR, Stefan RYSER, Angeles ESTELLES, Robert STEPHENSON, Reyna J. SIMON, Omar NOURZAIE
  • High affinity human antibodies to human cytomegalovirus (CMV) gB protein
    Patent number: 9017668
    Abstract: Antibodies to human Cytomegalovirus (CMV) gB protein have been isolated from human B cells. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: April 28, 2015
    Assignee: Trellis Bioscience, LLC
    Inventors: Lawrence M. Kauvar, Stote Ellsworth, William Usinger, Krista Maureen McCutcheon, Ying-Ping Jiang, Fen Zhang, Bo Chen, Gizette Sperinde, Minha Park, Orit Foord
  • BINDING MOIETIES FOR BIOFILM REMEDIATION
    Publication number: 20150086561
    Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
    Type: Application
    Filed: September 25, 2014
    Publication date: March 26, 2015
    Inventors: Lawrence M. KAUVAR, Stefan RYSER, Angeles ESTELLES, Robert STEPHENSON, Reyna J. SIMON, Omar NOURZAIE
  • ANTIBODIES IMMUNOREACTIVE WITH HEREGULIN-COUPLED HER3
    Publication number: 20140370548
    Abstract: Recombinant materials and methods for producing antibodies that specifically bind heregulin-coupled HER3, at a site distinct from the heregulin binding site, are described. These antibodies are particularly useful in treating cancer that expresses HER3.
    Type: Application
    Filed: September 2, 2014
    Publication date: December 18, 2014
    Inventors: Bruce KEYT, Lawrence M. KAUVAR, Ellen J. COLLARINI, Orit FOORD, Gizette SPERINDE, Marjan FATHOLAHI, Hung NGUYEN
  • ANTIBODIES USEFUL IN PASSIVE INFLUENZA IMMUNIZATION
    Publication number: 20140322210
    Abstract: Specific monoclonal antibodies and fragments including bispecific antibodies thereof that are crossreactive with multiple clades of influenza virus including both Group 1 and Group 2 representatives are disclosed. These antibodies are useful in controlling influenza epidemics and pandemics as well as in providing prophylactic or therapeutic protection against seasonal influenza.
    Type: Application
    Filed: December 5, 2012
    Publication date: October 30, 2014
    Inventors: Lawrence M. Kauvar, Stote Ellsworth, William Usinger, Krista Maureen McCutcheon, Minha Park
  • Antibodies immunoreactive with heregulin-coupled HER3
    Patent number: 8828388
    Abstract: Antibodies which specifically bind heregulin-coupled HER3, at a site distinct from the heregulin binding site, are described. These antibodies are particularly useful in treating cancer.
    Type: Grant
    Filed: January 17, 2013
    Date of Patent: September 9, 2014
    Assignee: Trellis Bioscience, LLC
    Inventors: Bruce Keyt, Lawrence M. Kauvar, Ellen J. Collarini, Orit Foord, Gizette Sperinde, Marjan Fatholahi, Hung Nguyen
  • PHARMACEUTICAL COMPOSITION FOR TREATING ISCHEMIC EVENTS
    Publication number: 20140127233
    Abstract: Methods and pharmaceutical compositions for treating severe ischemic events including cerebral infarction, cardiac infarction, or pulmonary embolism, comprising a thrombolytic intervention including thrombolytic agents and an inhibitor of vascular endothelial growth factor (VEGF) receptor-mediated signal transduction are disclosed.
    Type: Application
    Filed: January 9, 2014
    Publication date: May 8, 2014
    Applicant: NIIGATA UNIVERSITY
    Inventors: Takayoshi SHIMOHATA, Lawrence M. KAUVAR
  • Pharmaceutical composition for treating ischemic events
    Patent number: 8652476
    Abstract: Methods and pharmaceutical compositions for treating severe ischemic events including cerebral infarction, cardiac infarction, or pulmonary embolism, comprising a thrombolytic intervention including thrombolytic agents and an inhibitor of vascular endothelial growth factor (VEGF) receptor-mediated signal transduction are disclosed.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: February 18, 2014
    Assignee: Niigata University
    Inventors: Takayoshi Shimohata, Lawrence M. Kauvar
  • Cell-signaling assays
    Patent number: 8568973
    Abstract: Assays for detecting the presence and activity of cell-signaling components. These assays include luminescence polarization assays for detecting cell-signaling nucleotides and modulators of receptors and enzymes related to the generation and activity of such nucleotides.
    Type: Grant
    Filed: February 25, 2010
    Date of Patent: October 29, 2013
    Assignee: Molecular Devices, LLC
    Inventors: J. Richard Sportsman, Lawrence M. Kauvar
  • ANTI-RSV G PROTEIN ANTIBODIES
    Publication number: 20130034564
    Abstract: Individual monoclonal antibodies and fragments that bind a conserved epitope of the G protein of RSV and which are minimally immunogenic when administered to a human subject, are useful in treating RSV infections.
    Type: Application
    Filed: September 25, 2012
    Publication date: February 7, 2013
    Inventors: Lawrence M. KAUVAR, Ellen J. Collarini, Bruce Keyt, Orit Foord
  • Antibodies immunoreactive with heregulin-coupled HER3
    Patent number: 8362215
    Abstract: Antibodies which specifically bind heregulin-coupled HER3, at a site distinct from the heregulin binding site, are described. These antibodies are particularly useful in treating cancer.
    Type: Grant
    Filed: April 29, 2010
    Date of Patent: January 29, 2013
    Assignee: Trellis Bioscience, LLC
    Inventors: Bruce Keyt, Lawrence M. Kauvar, Ellen J. Collarini, Orit Foord, Gizette Sperinde, Marjan Fatholahi, Hung Nguyen
  • Anti-RSV G protein antibodies
    Patent number: 8273354
    Abstract: Individual monoclonal antibodies and fragments that bind a conserved epitope of the G protein of RSV and which are minimally immunogenic when administered to a human subject, are useful in treating RSV infections.
    Type: Grant
    Filed: May 12, 2010
    Date of Patent: September 25, 2012
    Assignee: Trellis RSV Holdings, Inc.
    Inventors: Lawrence M. Kauvar, Ellen J. Collarini, Bruce Keyt, Orit Foord
  • PHARMACEUTICAL COMPOSITION FOR TREATING ISCHEMIC EVENTS
    Publication number: 20120189631
    Abstract: Methods and pharmaceutical compositions for treating severe ischemic events including cerebral infarction, cardiac infarction, or pulmonary embolism, comprising a thrombolytic intervention including thrombolytic agents and an inhibitor of vascular endothelial growth factor (VEGF) receptor-mediated signal transduction are disclosed.
    Type: Application
    Filed: January 26, 2012
    Publication date: July 26, 2012
    Applicant: Niigata University
    Inventors: Takayoshi SHIMOHATA, Lawrence M. KAUVAR
  • HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN CYTOMEGALOVIRUS (CMV) GB PROTEIN
    Publication number: 20120020980
    Abstract: Antibodies to human Cytomegalovirus (CMV) gB protein have been isolated from human B cells. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.
    Type: Application
    Filed: June 16, 2011
    Publication date: January 26, 2012
    Applicant: TRELLIS BIOSCIENCE, INC.
    Inventors: LAWRENCE M. KAUVAR, STOTE ELLSWORTH, WILLIAM USINGER, KRISTA MAUREEN MCCUTCHEON, YING-PING JIANG, FEN ZHANG, BO CHEN, GIZETTE SPERINDE, MINHA PARK, ORIT FOORD
  • ANTIBODIES USEFUL IN PASSIVE INFLUENZA IMMUNIZATION
    Publication number: 20120020971
    Abstract: Monoclonal antibodies and fragments thereof that are crossreactive with multiple clades of influenza virus including both Group 1 and Group 2 representatives are disclosed. These antibodies are useful in controlling influenza epidemics and pandemics as well as in providing prophylactic or therapeutic protection against seasonal influenza.
    Type: Application
    Filed: June 17, 2011
    Publication date: January 26, 2012
    Applicant: Trellis Bioscience, Inc.
    Inventors: Lawrence M. KAUVAR, Stote Ellsworth, William Usinger, Krista M. McCutcheon, Minha Park, Bo Chen, Ying-Ping Jiang
  • Use of particulate labels in bioanalyte detection methods
    Patent number: 7939344
    Abstract: New applications for the use of distinguishable particulate labels available in a variety of hues and sized in the submicron range are described. These applications include profiling of cellular components, obtaining secretion patterns, identifying a multiplicity of components in chromatographic or electrophoretic techniques and identification of desired immunoglobulin secreting cells.
    Type: Grant
    Filed: August 8, 2008
    Date of Patent: May 10, 2011
    Assignee: Trellis Bioscience, Inc.
    Inventors: Lawrence M. Kauvar, Remy Cromer, William D. Harriman, Ellen J. Collarini
  • ANTIBODIES IMMUNOREACTIVE WITH HEREGULIN-COUPLED HER3
    Publication number: 20100310557
    Abstract: Antibodies which specifically bind heregulin-coupled HER3, at a site distinct from the heregulin binding site, are described. These antibodies are particularly useful in treating cancer.
    Type: Application
    Filed: April 29, 2010
    Publication date: December 9, 2010
    Inventors: Bruce KEYT, Lawrence M. KAUVAR, Ellen J. COLLARINI, Orit FOORD, Gizette SPERINDE, Marjan FATHOLAHI, Hung NGUYEN
  • ANTI-RSV G PROTEIN ANTIBODIES
    Publication number: 20100285022
    Abstract: Individual monoclonal antibodies and fragments that bind a conserved epitope of the G protein of RSV and which are minimally immunogenic when administered to a human subject, are useful in treating RSV infections.
    Type: Application
    Filed: May 12, 2010
    Publication date: November 11, 2010
    Inventors: Lawrence M. KAUVAR, Ellen J. Collarini, Bruce Keyt, Orit Foord