Patents by Inventor Lawrence O. Hall
Lawrence O. Hall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11803968Abstract: Systems and methods for automated stereology are provided. A method can include providing an imager for capturing a Z-stack of images of a three-dimensional (3D) object; constructing extended depth of field (EDF) images from the Z-stack of images; performing a segmentation method on the EDF images including estimating a Gaussian Mixture Model (GMM), performing morphological operations, performing watershed segmentation, constructing Voronoi diagrams and performing boundary smoothing; and determining one or more stereology parameters such as number of cells in a region.Type: GrantFiled: May 5, 2021Date of Patent: October 31, 2023Assignees: UNIVERSITY OF SOUTH FLORIDA, STEREOLOGY RESOURCE CENTER, INC.Inventors: Peter Randolph Mouton, Hady Ahmady Phoulady, Dmitry Goldgof, Lawrence O. Hall
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Publication number: 20230127698Abstract: Systems and methods for automated stereology using deep learning are disclosed. The systems include an update in the form of a semi-automatic approach for ground truth preparation in 3D stacks of microscopy images (disector stacks) for generating more training data. The systems also present an exemplary disector-based MIMO framework where all the planes of a 3D disector stack are analyzed as opposed to a single focus-stacked image (EDF image) per stack. The MIMO approach avoids the costly computations of 3D deep learning-based methods by using the 3D context of cells in disector stacks; and prevents stereological bias in the previous EDF-based method due to counting profiles rather than cells and under-counting overlap-ping/occluded cells. Taken together, these improvements support the view that AI-based automatic deep learning methods can accelerate the efficiency of unbiased stereology cell counts without a loss of accuracy or precision as compared to conventional manual stereology.Type: ApplicationFiled: October 21, 2022Publication date: April 27, 2023Inventors: Palak Pankajbhai Dave, Dmitry Goldgof, Lawrence O. Hall, Peter R. Mouton
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Publication number: 20220058369Abstract: Systems and methods for automated stereology are provided. In some embodiments, an active deep learning approach may be utilized to allow for a faster and more efficient training of a deep learning model for stereology analysis. In other embodiments, existing deep learning models for stereology analysis may be re-tuned to develop greater accuracy for a given data set of interest, either with or without an active deep learning approach.Type: ApplicationFiled: August 9, 2021Publication date: February 24, 2022Inventors: Saeed S. Alahmari, Dmitry Goldgof, Lawrence O. Hall, Peter R. Mouton
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Publication number: 20210343015Abstract: Systems and methods for automated stereology are provided. A method can include providing an imager for capturing a Z-stack of images of a three-dimensional (3D) object; constructing extended depth of field (EDF) images from the Z-stack of images; performing a segmentation method on the EDF images including estimating a Gaussian Mixture Model (GMM), performing morphological operations, performing watershed segmentation, constructing Voronoi diagrams and performing boundary smoothing; and determining one or more stereology parameters such as number of cells in a region.Type: ApplicationFiled: May 5, 2021Publication date: November 4, 2021Inventors: PETER RANDOLPH MOUTON, HADY AHMADY PHOULADY, DMITRY GOLDGOF, LAWRENCE O. HALL
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Patent number: 11004199Abstract: Systems and methods for automated stereology are provided. A method can include providing an imager for capturing a Z-stack of images of a three-dimensional (3D) object; constructing extended depth of field (EDF) images from the Z-stack of images; performing a segmentation method on the EDF images including estimating a Gaussian Mixture Model (GMM), performing morphological operations, performing watershed segmentation, constructing Voronoi diagrams and performing boundary smoothing; and determining one or more stereology parameters such as number of cells in a region.Type: GrantFiled: November 10, 2017Date of Patent: May 11, 2021Assignees: UNIVERSITY OF SOUTH FLORIDA, STEREOLOGY RESOURCE CENTER, INC.Inventors: Peter Randolph Mouton, Hady Ahmady Phoulady, Dmitry Goldgof, Lawrence O. Hall
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Patent number: 10827945Abstract: Virtually every cancer patient is imaged with CT, PET or MRI. Importantly, such imaging reveals that tumors are complex and heterogeneous, often containing multiple habitats within them. Disclosed herein are methods for analyzing these images to infer cellular and molecular structure in each of these habitats. The methods can involve spatially superimposing two or more radiological images of the tumor sufficient to define regional habitat variations in two or more ecological dynamics in the tumor, and comparing the habitat variations to one or more controls to predict the severity of the tumor.Type: GrantFiled: March 10, 2015Date of Patent: November 10, 2020Assignees: H. LEE. MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., UNIVERSITY OF SOUTH FLORIDAInventors: Robert J. Gillies, Robert A. Gatenby, Natarajan Raghunand, John Arrington, Olya Stringfield, Yoganand Balagurunathan, Dmitry B. Goldgof, Lawrence O. Hall
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Patent number: 10713787Abstract: Systems and methods for applying an ensemble of segmentations to microscopy images of a tissue sample to determine if the tissue sample is representative of cancerous tissue. The ensemble of segmentations is applied to a plurality of greyscale or color microscopy images to generate a final image level segmentation and a final blob level segmentation. The final image level segmentation and final blob level segmentation are used to calculate a mean nuclear volume to determine if the tissue sample is representative of cancerous tissue.Type: GrantFiled: October 1, 2018Date of Patent: July 14, 2020Assignees: University of South Florida, Stereology Resource Center, Inc.Inventors: Peter Randolph Mouton, Dmitry Goldgof, Lawrence O. Hall, Baishali Chaudhury
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Publication number: 20200211180Abstract: An example method for diagnosing tumors in a subject by performing a quantitative analysis of a radiological image can include identifying a region of interest (ROI) in the radiological image, segmenting the ROI from the radiological image, identifying a tumor object in the segmented ROI and segmenting the tumor object from the segmented ROI. The method can also include extracting a plurality of quantitative features describing the segmented tumor object, and classifying the tumor object based on the extracted quantitative features. The quantitative features can include one or more texture-based features.Type: ApplicationFiled: August 5, 2019Publication date: July 2, 2020Inventors: Robert J. Gillies, Lawrence O. Hall, Dmitry B. Goldgof
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Publication number: 20190272638Abstract: Systems and methods for automated stereology are provided. A method can include providing an imager for capturing a Z-stack of images of a three-dimensional (3D) object; constructing extended depth of field (EDF) images from the Z-stack of images; performing a segmentation method on the EDF images including estimating a Gaussian Mixture Model (GMM), performing morphological operations, performing watershed segmentation, constructing Voronoi diagrams and performing boundary smoothing; and determining one or more stereology parameters such as number of cells in a region.Type: ApplicationFiled: November 10, 2017Publication date: September 5, 2019Inventors: PETER RANDOLPH MOUTON, HADY AHMADY PHOULADY, DMITRY GOLDGOF, LAWRENCE O. HALL
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Patent number: 10373314Abstract: An example method for diagnosing tumors in a subject by performing a quantitative analysis of a radiological image can include identifying a region of interest (ROI) in the radiological image, segmenting the ROI from the radiological image, identifying a tumor object in the segmented ROI and segmenting the tumor object from the segmented ROI. The method can also include extracting a plurality of quantitative features describing the segmented tumor object, and classifying the tumor object based on the extracted quantitative features. The quantitative features can include one or more texture-based features.Type: GrantFiled: February 28, 2018Date of Patent: August 6, 2019Assignees: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., UNIVERSITY OF SOUTH FLORIDAInventors: Robert J. Gillies, Lawrence O. Hall, Dmitry B. Goldgof
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Publication number: 20190043189Abstract: Systems and methods for applying an ensemble of segmentations to microscopy images of a tissue sample to determine if the tissue sample is representative of cancerous tissue. The ensemble of segmentations is applied to a plurality of greyscale or color microscopy images to generate a final image level segmentation and a final blob level segmentation. The final image level segmentation and final blob level segmentation are used to calculate a mean nuclear volume to determine if the tissue sample is representative of cancerous tissue.Type: ApplicationFiled: October 1, 2018Publication date: February 7, 2019Inventors: Peter Randolph Mouton, Dmitry Goldgof, Lawrence O. Hall, Baishali Chaudhury
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Patent number: 10096110Abstract: This invention relates to a system and method for applying an ensemble of segmentations to microscopy images of a tissue sample to determine if the tissue sample is representative of cancerous tissue. The ensemble of segmentations is applied to a plurality of greyscale or color microscopy images to generate a final image level segmentation and a final blob level segmentation. The final image level segmentation and final blob level segmentation are used to calculate a mean nuclear volume to determine if the tissue sample is representative of cancerous tissue.Type: GrantFiled: August 24, 2015Date of Patent: October 9, 2018Assignees: University of South Florida, Stereology Resource Center, Inc.Inventors: Peter Randolph Mouton, Dmitry Goldgof, Lawrence O. Hall, Baishali Chaudhury
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Publication number: 20180253843Abstract: An example method for diagnosing tumors in a subject by performing a quantitative analysis of a radiological image can include identifying a region of interest (ROI) in the radiological image, segmenting the ROI from the radiological image, identifying a tumor object in the segmented ROI and segmenting the tumor object from the segmented ROI. The method can also include extracting a plurality of quantitative features describing the segmented tumor object, and classifying the tumor object based on the extracted quantitative features. The quantitative features can include one or more texture-based features.Type: ApplicationFiled: February 28, 2018Publication date: September 6, 2018Inventors: Robert J. Gillies, Lawrence O. Hall, Dmitry B. Goldgof
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Patent number: 9940709Abstract: An example method for diagnosing tumors in a subject by performing a quantitative analysis of a radiological image can include identifying a region of interest (ROI) in the radiological image, segmenting the ROI from the radiological image, identifying a tumor object in the segmented ROI and segmenting the tumor object from the segmented ROI. The method can also include extracting a plurality of quantitative features describing the segmented tumor object, and classifying the tumor object based on the extracted quantitative features. The quantitative features can include one or more texture-based features.Type: GrantFiled: October 10, 2014Date of Patent: April 10, 2018Assignees: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., UNIVERSITY OF SOUTH FLORIDAInventors: Robert J. Gillies, Lawrence O. Hall, Dmitry B. Goldgof
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Publication number: 20170236278Abstract: A system and method for applying an ensemble of segmentations to a tissue sample at a blob level and at an image level to determine if the tissue sample is representative of cancerous tissue. The ensemble of segmentations at the image level is used to accept or reject images based upon the segmentation quality of the images and both the blob level segmentation and the image level segmentation are used to calculate a mean nuclear volume to discriminate between cancer and normal classes of tissue samples.Type: ApplicationFiled: August 24, 2015Publication date: August 17, 2017Inventors: Peter Randolph Mouton, Dmitry Goldgof, Lawrence O. Hall, Baishali Chaudhury
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Publication number: 20170071496Abstract: Virtually every cancer patient is imaged with CT, PET or MRI. Importantly, such imaging reveals that tumors are complex and heterogeneous, often containing multiple habitats within them. Disclosed herein are methods for analyzing these images to infer cellular and molecular structure in each of these habitats. The methods can involve spatially superimposing two or more radiological images of the tumor sufficient to define regional habitat variations in two or more ecological dynamics in the tumor, and comparing the habitat variations to one or more controls to predict the severity of the tumor.Type: ApplicationFiled: March 10, 2015Publication date: March 16, 2017Inventors: Robert J. Gillies, Robert A. Gatenby, Natarajan Raghunand, John Arrington, Olya Stringfield, Yoganand Balagurunathan, Dmitry B. Goldgof, Lawrence O. Hall
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Publication number: 20160260211Abstract: An example method for diagnosing tumors in a subject by performing a quantitative analysis of a radiological image can include identifying a region of interest (ROI) in the radiological image, segmenting the ROI from the radiological image, identifying a tumor object in the segmented ROI and segmenting the tumor object from the segmented ROI. The method can also include extracting a plurality of quantitative features describing the segmented tumor object, and classifying the tumor object based on the extracted quantitative features. The quantitative features can include one or more texture-based features.Type: ApplicationFiled: October 10, 2014Publication date: September 8, 2016Inventors: Robert J. Gillies, Lawrence O. Hall, Dmitry B. Goldgof
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Patent number: 9297995Abstract: Systems and methods are provided for automatic determination of slice thickness of an image stack in a computerized stereology system, as well as automatic quantification of biological objects of interest within an identified slice of the image stack. Top and bottom boundaries of a slice can be identified by applying a thresholded focus function to determine just-out-of-focus focal planes. Objects within an identified slice can be quantified by performing a color processing segmentation followed by a gray-level processing segmentation. The two segmentation processes generate unique identifiers for features in an image that can then be used to produce a count of the features.Type: GrantFiled: February 13, 2012Date of Patent: March 29, 2016Assignees: UNIVERSITY OF SOUTH FLORIDA, STEREOLOGY RESOURCE CENTER, INC.Inventors: Kurt A. Kramer, Peter R. Mouton, Lawrence O. Hall, Dmitry Goldgof, Daniel T. Elozory, Om Pavithra Bonam, Baishali Chaudhury
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Publication number: 20120236120Abstract: Systems and methods are provided for automatic determination of slice thickness of an image stack in a computerized stereology system, as well as automatic quantification of biological objects of interest within an identified slice of the image stack. Top and bottom boundaries of a slice can be identified by applying a thresholded focus function to determine just-out-of-focus focal planes. Objects within an identified slice can be quantified by performing a color processing segmentation followed by a gray-level processing segmentation. The two segmentation processes generate unique identifiers for features in an image that can then be used to produce a count of the features.Type: ApplicationFiled: February 13, 2012Publication date: September 20, 2012Applicants: Stereology Resource Center, Inc., University of South FloridaInventors: Kurt A. Kramer, Peter R. Mouton, Lawrence O. Hall, Dmitry Goldgof, Daniel T. Elozory, Om Pavithra Bonam, Baishali Chaudhury