Patents by Inventor Lawrence X. Webb
Lawrence X. Webb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9737455Abstract: A tissue treatment apparatus and method are provided for treating tissue by the application of the time-varying sub-atmospheric pressure. The apparatus includes a cover adapted to cover a wound and adapted to maintain sub-atmospheric pressure the site of the wound. The apparatus further includes a source of suction configured to generate a time-varying sub-atmospheric pressure having a periodic waveform comprising a gradual change in pressure. The suction source cooperates with the cover to supply the time-varying sub-atmospheric pressure under the cover to the wound. The time-varying sub-atmospheric pressure may vary between a first pressure value below the inherent tissue tension of the wound tissue and a second pressure value above the inherent tissue tension of the wound tissue.Type: GrantFiled: November 18, 2013Date of Patent: August 22, 2017Assignee: WAKE FOREST UNIVERISTY HEALTH SCIENCESInventors: Louis C Argenta, Michael J Morykwas, Lawrence X Webb
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Patent number: 9671301Abstract: The present invention provides a method of sensing pressure in a region of interest by providing a plurality of metallic particles operatively associated with one another in the region of interest (for example, wherein the metallic particles sustain a plasmon upon excitation), and with the metallic particles configured or positioned in relationship to one another so that a physical property of the particles (for example, the energy of the plasmon) varies in response to pressure; measuring the physical property of the metallic particles that varies in response to pressure; and then determining the pressure in the region of interest from the detected physical property (e.g., resistance, energy of the plasmon). Compositions, articles and formulations for carrying out the method in industrial and biomedical applications are also described.Type: GrantFiled: September 28, 2007Date of Patent: June 6, 2017Assignee: Wake Forest University Health SciencesInventors: David L. Carroll, Faith M. Coldren, Nicole H. Levi, Lawrence X. Webb, William D. Wagner, Thomas L. Smith, Brian Werner, J. Baxter Mcguirt, Manoj Namboothiry
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Patent number: 9566089Abstract: An external fixation assembly includes a plurality of hollow pins that are inserted into a patient's bone. Each pin has an interior bore and a plurality of apertures extending through the pin wall from the bore. The pin may be coupled to a source of vacuum pressure operable to create reduced pressure in the tissue surrounding the pin. A cover is placed around the pin and sealed to provide a fluid-tight enclosure that maintains reduced pressure around the pin. A method for applying external fixation using the fixator pins described above includes the steps of inserting each pin through a skin opening, positioning the pin apertures near selected tissue, covering the skin opening with a sealed enclosure, connecting the pins to a source of vacuum pressure, and activating the source of vacuum pressure to create reduced pressure in the patient's tissue at or near the bone.Type: GrantFiled: May 18, 2015Date of Patent: February 14, 2017Assignee: Wake Forest University Health SciencesInventors: Lawrence X. Webb, Louis C. Argenta, Michael J. Morykwas
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Publication number: 20150245854Abstract: An external fixation assembly includes a plurality of hollow pins that are inserted into a patient's bone. Each pin has an interior bore and a plurality of apertures extending through the pin wall from the bore. The pin may be coupled to a source of vacuum pressure operable to create reduced pressure in the tissue surrounding the pin. A cover is placed around the pin and sealed to provide a fluid-tight enclosure that maintains reduced pressure around the pin. A method for applying external fixation using the fixator pins described above includes the steps of inserting each pin through a skin opening, positioning the pin apertures near selected tissue, covering the skin opening with a sealed enclosure, connecting the pins to a source of vacuum pressure, and activating the source of vacuum pressure to create reduced pressure in the patient's tissue at or near the bone.Type: ApplicationFiled: May 18, 2015Publication date: September 3, 2015Inventors: Lawrence X. Webb, Louis C. Argenta, Michael J. Morykwas
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Patent number: 9050136Abstract: An external fixation assembly includes a plurality of hollow pins that are inserted into a patient's bone. Each pin has an interior bore and a plurality of apertures extending through the pin wall from the bore. The pin may be coupled to a source of vacuum pressure operable to create reduced pressure in the tissue surrounding the pin. A cover is placed around the pin and sealed to provide a fluid-tight enclosure that maintains reduced pressure around the pin. A method for applying external fixation using the fixator pins described above includes the steps of inserting each pin through a skin opening, positioning the pin apertures near selected tissue, covering the skin opening with a sealed enclosure, connecting the pins to a source of vacuum pressure, and activating the source of vacuum pressure to create reduced pressure in the patient's tissue at or near the bone.Type: GrantFiled: May 17, 2013Date of Patent: June 9, 2015Assignee: WAKE FOREST UNIVERSITY HEALTH SCIENCESInventors: Lawrence X Webb, Louis C Argenta, Michael J Morykwas
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Publication number: 20140155790Abstract: A tissue treatment apparatus and method are provided for treating tissue by the application of the time-varying sub-atmospheric pressure. The apparatus includes a cover adapted to cover a wound and adapted to maintain sub-atmospheric pressure the site of the wound. The apparatus further includes a source of suction configured to generate a time-varying sub-atmospheric pressure having a periodic waveform comprising a gradual change in pressure. The suction source cooperates with the cover to supply the time-varying sub-atmospheric pressure under the cover to the wound. The time-varying sub-atmospheric pressure may vary between a first pressure value below the inherent tissue tension of the wound tissue and a second pressure value above the inherent tissue tension of the wound tissue.Type: ApplicationFiled: November 18, 2013Publication date: June 5, 2014Applicant: Wake Forest University Health SciencesInventors: Louis C. Argenta, Michael J. Morykwas, Lawrence X. Webb
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Publication number: 20130267952Abstract: An external fixation assembly includes a plurality of hollow pins that are inserted into a patient's bone. Each pin has an interior bore and a plurality of apertures extending through the pin wall from the bore. The pin may be coupled to a source of vacuum pressure operable to create reduced pressure in the tissue surrounding the pin. A cover is placed around the pin and sealed to provide a fluid-tight enclosure that maintains reduced pressure around the pin. A method for applying external fixation using the fixator pins described above includes the steps of inserting each pin through a skin opening, positioning the pin apertures near selected tissue, covering the skin opening with a sealed enclosure, connecting the pins to a source of vacuum pressure, and activating the source of vacuum pressure to create reduced pressure in the patient's tissue at or near the bone.Type: ApplicationFiled: May 17, 2013Publication date: October 10, 2013Inventors: Lawrence X. Webb, Louis C. Argenta, Michael J. Morykwas
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Patent number: 8454603Abstract: An external fixation assembly includes a plurality of hollow pins that are inserted into a patient's bone. Each pin has an interior bore and a plurality of apertures extending through the pin wall from the bore. The pin may be coupled to a source of vacuum pressure operable to create reduced pressure in the tissue surrounding the pin. A cover is placed around the pin and sealed to provide a fluid-tight enclosure that maintains reduced pressure around the pin. A method for applying external fixation using the fixator pins described above includes the steps of inserting each pin through a skin opening, positioning the pin apertures near selected tissue, covering the skin opening with a sealed enclosure, connecting the pins to a source of vacuum pressure, and activating the source of vacuum pressure to create reduced pressure in the patient's tissue at or near the bone.Type: GrantFiled: April 26, 2011Date of Patent: June 4, 2013Assignee: Wake Forest University Health SciencesInventors: Lawrence X. Webb, Louis C. Argenta, Michael J. Morykwas
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Patent number: 8377016Abstract: A tissue treatment apparatus and method are provided for treating tissue by the application of the time-varying sub-atmospheric pressure. The apparatus includes a cover adapted to cover a wound and adapted to maintain sub-atmospheric pressure the site of the wound. The apparatus further includes a source of suction configured to generate a time-varying sub-atmospheric pressure having a periodic waveform comprising a gradual change in pressure. The suction source cooperates with the cover to supply the time-varying sub-atmospheric pressure under the cover to the wound. The time-varying sub-atmospheric pressure may vary between a first pressure value below the inherent tissue tension of the wound tissue and a second pressure value above the inherent tissue tension of the wound tissue.Type: GrantFiled: January 10, 2007Date of Patent: February 19, 2013Assignee: Wake Forest University Health SciencesInventors: Louis O. Argenta, Michael J. Morykwas, Lawrence X. Webb
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Publication number: 20110202059Abstract: An external fixation assembly includes a plurality of hollow pins that are inserted into a patient's bone. Each pin has an interior bore and a plurality of apertures extending through the pin wall from the bore. The pin may be coupled to a source of vacuum pressure operable to create reduced pressure in the tissue surrounding the pin. A cover is placed around the pin and sealed to provide a fluid-tight enclosure that maintains reduced pressure around the pin. A method for applying external fixation using the fixator pins described above includes the steps of inserting each pin through a skin opening, positioning the pin apertures near selected tissue, covering the skin opening with a sealed enclosure, connecting the pins to a source of vacuum pressure, and activating the source of vacuum pressure to create reduced pressure in the patient's tissue at or near the bone.Type: ApplicationFiled: April 26, 2011Publication date: August 18, 2011Inventors: Lawrence X. Webb, Louis C. Argenta, Michael J. Morykwas
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Patent number: 7931651Abstract: An external fixation assembly includes a plurality of hollow pins that are inserted into a patient's bone. Each pin has an interior bore and a plurality of apertures extending through the pin wall from the bore. The pin may be coupled to a source of vacuum pressure operable to create reduced pressure in the tissue surrounding the pin. A cover is placed around the pin and sealed to provide a fluid-tight enclosure that maintains reduced pressure around the pin. A method for applying external fixation using the fixator pins described above includes the steps of inserting each pin through a skin opening, positioning the pin apertures near selected tissue, covering the skin opening with a sealed enclosure, connecting the pins to a source of vacuum pressure, and activating the source of vacuum pressure to create reduced pressure in the patient's tissue at or near the bone.Type: GrantFiled: March 30, 2007Date of Patent: April 26, 2011Assignee: Wake Lake University Health SciencesInventors: Lawrence X. Webb, Louis C. Argenta, Michael J. Morykwas
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Publication number: 20100185121Abstract: The present invention provides a method of sensing pressure in a region of interest by providing a plurality of metallic particles operatively associated with one another in the region of interest (for example, wherein the metallic particles sustain a plasmon upon excitation), and with the metallic particles configured or positioned in relationship to one another so that a physical property of the particles (for example, the energy of the plasmon) varies in response to pressure; measuring the physical property of the metallic particles that varies in response to pressure; and then determining the pressure in the region of interest from the detected physical property (e.g., resistance, energy of the plasmon). Compositions, articles and formulations for carrying out the method in industrial and biomedical applications are also described.Type: ApplicationFiled: September 28, 2007Publication date: July 22, 2010Applicants: WAKE FOREST UNIVERSITY HEALTH SCIENCES, WAKE FOREST UNIVERSITYInventors: David L. Carroll, Faith M. Coldren, Nicole H. Levi, Lawrence X. Webb, William D. Wagner, Thomas L. Smith, Brian Werner, J. Baxter Mcguirt, Manoj Namboothiry
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Publication number: 20080281324Abstract: An external fixation assembly includes a plurality of hollow pins that are inserted into a patient's bone. Each pin has an interior bore and a plurality of apertures extending through the pin wall from the bore. The pin may be coupled to a source of vacuum pressure operable to create reduced pressure in the tissue surrounding the pin. A cover is placed around the pin and sealed to provide a fluid-tight enclosure that maintains reduced pressure around the pin. A method for applying external fixation using the fixator pins described above includes the steps of inserting each pin through a skin opening, positioning the pin apertures near selected tissue, covering the skin opening with a sealed enclosure, connecting the pins to a source of vacuum pressure, and activating the source of vacuum pressure to create reduced pressure in the patient's tissue at or near the bone.Type: ApplicationFiled: March 30, 2007Publication date: November 13, 2008Inventors: Lawrence X. Webb, Louis C. Argenta, Michael J. Morykwas
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Publication number: 20080208147Abstract: A tissue treatment apparatus and method are provided for treating tissue by the application of the time-varying sub-atmospheric pressure. The apparatus includes a cover adapted to cover a wound and adapted to maintain sub-atmospheric pressure the site of the wound. The apparatus further includes a source of suction configured to generate a time-varying sub-atmospheric pressure having a periodic waveform comprising a gradual change in pressure. The suction source cooperates with the cover to supply the time-varying sub-atmospheric pressure under the cover to the wound. The time-varying sub-atmospheric pressure may vary between a first pressure value below the inherent tissue tension of the wound tissue and a second pressure value above the inherent tissue tension of the wound tissue.Type: ApplicationFiled: January 10, 2007Publication date: August 28, 2008Inventors: Louis O. Argenta, Michael J. Morykwas, Lawrence X. Webb
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Publication number: 20080208171Abstract: The present invention relates to a device and method for removing edema from an edematous tissue. The device includes at least one aciculated component disposed in fluid communication with a suction manifold. A suction source is fluidically connected to the suction manifold to provide a suction force to the suction manifold. The suction force is transmitted through the suction manifold to the at least one aciculated component to withdraw the edema from edematous tissue through the suction manifold and the at least one aciculated component.Type: ApplicationFiled: February 23, 2007Publication date: August 28, 2008Inventors: Louis C. Argenta, Michael J. Morykwas, Lawrence X. Webb
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Publication number: 20080181955Abstract: A dietary supplement includes resveratrol in a therapeutically effective amount to permit release of nitric oxide (NO) during sexual stimulation and at least one polyphenol in a therapeutically effective amount to inhibit formation of type 5 phosphodiesterase (PDE-5). The dietary supplement is a dry powder derived from Muscadine grapes that are pressed and then stored at a temperature greater than 32° F. (0° C.) and less than 60° F. (15° C.) for at least 14 days. The pressed and stored grapes are dried and then ground into the dry powder. The concentration of the resveratrol is between 0.01 mg and 100 mg per 100 g of dry powder and the concentration of the polyphenol is between 0.04 mg and 400 mg per 100 g. A method for enhancing human libido includes providing the dry powder and consuming at least 50 mg of the dry powder daily for a period of at least 21 days.Type: ApplicationFiled: January 30, 2007Publication date: July 31, 2008Inventor: Lawrence X. Webb
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Publication number: 20040122434Abstract: A method of treating bone tissue damage is provided which includes applying a reduced pressure to a damaged bone tissue sufficient in time and magnitude to promote healing of the damaged bone tissue. A bone tissue treatment apparatus is provided in which a cover is sealed over a bone tissue site. A screen in the form of an open-cell foam screen or a rigid porous screen may be placed beneath the tissue cover over the damaged bone tissue. A vacuum pump supplies suction within the tissue cover over the treatment site. The cover may be sealed over an area of intact skin above damaged bone tissue. The vacuum pump supplies reduced pressure within the tissue cover over the area of intact skin to treat the damaged bone tissue beneath the area of skin.Type: ApplicationFiled: August 22, 2003Publication date: June 24, 2004Inventors: Louis C. Argenta, Michael J. Morykwas, Lawrence X. Webb
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Publication number: 20040039391Abstract: A method of treating bone tissue damage is provided which includes applying a reduced pressure to a damaged bone tissue sufficient in time and magnitude to promote healing of the damaged bone tissue. A bone tissue treatment apparatus is provided in which a fluid impermeable tissue cover is sealed over a bone tissue site. A screen in the form of an open-cell foam screen or a rigid porous screen is placed beneath the tissue cover over the damaged bone tissue. A vacuum pump supplies suction within the tissue cover over the treatment site.Type: ApplicationFiled: August 23, 2002Publication date: February 26, 2004Inventors: Louis C. Argenta, Michael J. Morykwas, Lawrence X. Webb
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Publication number: 20030225347Abstract: A tissue growth apparatus and method are provided for growing tissue by applying a tissue growth medium to the tissue and applying reduced, sub-atmospheric pressure at the growth medium and the tissue in a controlled manner for a selected time period. The application of reduced pressure at the growth medium and tissue promotes growth of the tissue within the tissue growth medium. The apparatus includes a tissue cover sealed over a tissue site. The apparatus also includes a tissue growth medium located beneath the tissue cover and in contact with the tissue to be grown. A vacuum pump supplies suction within the tissue cover over the tissue site to provide reduced pressure to the tissue and the tissue growth medium.Type: ApplicationFiled: June 3, 2002Publication date: December 4, 2003Inventors: Louis C. Argenta, Michael J. Morykwas, Lawrence X. Webb