Abstract: A novel gRNA-ligand binding complex is provided. This complex may be used to bring Type V Cas proteins and additional effectors to DNA for base editing. The design of the systems allows for the production of efficient modular components that provide flexibility when editing DNA.

Abstract: A fluid management and medical device system may include a fluid management system and a medical device having one or more sensors proximate the distal end of the elongate shaft of the medical device. The controller of the fluid management system may be configured to calculate a fluid deficit when the distal end of the elongate shaft is disposed within a patient and configured to automatically pause fluid deficit calculation when the distal end of the elongate shaft is removed from the patient. In some instances the controller is configured to calculate the fluid deficit using rotational speed of the inflow pump in combination with a difference between a change in weight of a fluid supply source supplying fluid to the fluid management system and a change in weight of a collection container collecting fluid from the fluid management system.

Abstract: A wearable posture monitoring device is provided. The device includes a first posture sensor to measure a first bend parameter associated with shoulders of a user and a second posture sensor to measure a second bend parameter associated with vertebral column of the user. The device includes a control unit operatively coupled to the first posture sensor and the second posture sensor and is configured to compare the first bend parameter with a first predefined reference value and the second bend parameter with a second predefined reference value to detect an improper bend in one or more of the shoulders and vertebral column of the user. The control unit is further configured to display a visual indication, on a display interface associated with the posture monitoring device, to indicate the detected improper bend of one or more of the shoulders and vertebral column of the user.

Abstract: A wearable posture monitoring device is provided. The device includes a first posture sensor to measure a first bend parameter associated with shoulders of a user and a second posture sensor to measure a second bend parameter associated with vertebral column of the user. The device includes a control unit operatively coupled to the first posture sensor and the second posture sensor and is configured to compare the first bend parameter with a first predefined reference value and the second bend parameter with a second predefined reference value to detect an improper bend in one or more of the shoulders and vertebral column of the user. The control unit is further configured to display a visual indication, on a display interface associated with the posture monitoring device, to indicate the detected improper bend of one or more of the shoulders and vertebral column of the user.