Patents by Inventor Leah Tolosa

Leah Tolosa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230323277
    Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
    Type: Application
    Filed: June 6, 2023
    Publication date: October 12, 2023
    Inventors: Govind RAO, Yordan KOSTOV, Leah TOLOSA, Xudong GE, Douglas Frey
  • Publication number: 20230243815
    Abstract: An automatic and continuous glucose monitoring apparatus and method of using same based on binding proteins. The apparatus integrates an aseptic sampling technique, a specially modified chromatography column to hold immobilized binding protein, and a microfluorometer into a compact portable device. The apparatus permits the measurement of a very wide range of concentrations—from a few micromolar to several hundreds of millimolar of glucose.
    Type: Application
    Filed: May 21, 2021
    Publication date: August 3, 2023
    Inventors: Leah Tolosa CROUCHER, Govind RAO, Xudong GE, Abhay ANDAR, Hasibul HASAN, Sheniqua BROWN, Yordan KOSTOV, Chad SUNDBERG, Vikash KUMAR, Shayan BORHANI, Sarah BURNEY, Samyukta RAO
  • Patent number: 11702625
    Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
    Type: Grant
    Filed: July 15, 2021
    Date of Patent: July 18, 2023
    Assignee: University of Maryland, Baltimore County
    Inventors: Govind Rao, Yordan Kostov, Leah Tolosa, Xudong Ge, Douglas Frey
  • Publication number: 20220298469
    Abstract: A bioprocessing system for protein manufacturing from human blood is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The patient's own blood can be used as the source of cell extracts for the production of the therapeutic proteins.
    Type: Application
    Filed: June 10, 2022
    Publication date: September 22, 2022
    Inventors: Govind RAO, Yordan KOSTOV, Leah TOLOSA, Kevin TRAN, Monohar Pilli, Michael TOLOSA, Chandrashekar Gurramkonda, Xudong GE, Douglas Frey
  • Publication number: 20210340488
    Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
    Type: Application
    Filed: July 15, 2021
    Publication date: November 4, 2021
    Inventors: Govind RAO, Yordan KOSTOV, Leah TOLOSA, Xudong GE, Douglas Frey
  • Patent number: 10774304
    Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
    Type: Grant
    Filed: October 23, 2019
    Date of Patent: September 15, 2020
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventors: Govind Rao, Yordan Kostov, Leah Tolosa, Xudong Ge, Douglas Frey, Shayan Gholipour Borhani, David Burgenson
  • Publication number: 20200095534
    Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
    Type: Application
    Filed: October 23, 2019
    Publication date: March 26, 2020
    Inventors: GOVIND RAO, YORDAN KOSTOV, LEAH TOLOSA, XUDONG GE, DOUGLAS FREY, SHAYAN GHOLIPOUR BORHANI, DAVID BURGENSON
  • Publication number: 20190330586
    Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
    Type: Application
    Filed: July 9, 2019
    Publication date: October 31, 2019
    Inventors: Govind RAO, Yordan KOSTOV, Leah TOLOSA, Xudong GE, Douglas Frey
  • Patent number: 10435664
    Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: October 8, 2019
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventors: Govind Rao, Yordan Kostov, Leah Tolosa, Xudong Ge, Douglas Frey
  • Publication number: 20180298325
    Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
    Type: Application
    Filed: April 30, 2018
    Publication date: October 18, 2018
    Inventors: Govind RAO, Yordan KOSTOV, Leah TOLOSA, Xudong GE, Douglas Frey
  • Patent number: 9982227
    Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: May 29, 2018
    Assignee: University of Maryland, Baltimore County
    Inventors: Govind Rao, Yordan Kostov, Leah Tolosa, Xudong Ge, Douglas Frey
  • Patent number: 9883823
    Abstract: Systems and methods for determining an in vivo concentration of a small molecule substance of interest is provided that takes advantage of the semi-permeable nature of skin, which allows small molecules to passively diffuse through the skin and onto the skin surface. The systems and methods of the present invention allow for the collection of these small molecules that have passively diffused through the skin without skin disruption or breaking of the skin. The systems and methods of the present invention are noninvasive, painless and safe even for delicate newborns, and are particularly suited for the determination of blood glucose in newborns and infants in a noninvasive manner.
    Type: Grant
    Filed: February 4, 2013
    Date of Patent: February 6, 2018
    Assignee: University of Maryland Baltimore County
    Inventors: Leah Tolosa, Xudong Ge, Yordan Kostov, Michael Tolosa, Govind Rao
  • Publication number: 20170226467
    Abstract: A bioprocessing system for protein manufacturing from human blood is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The patient's own blood can be used as the source of cell extracts for the production of the therapeutic proteins.
    Type: Application
    Filed: July 31, 2015
    Publication date: August 10, 2017
    Inventors: Govind Rao, Yordan Kostov, Leah Tolosa, Kevin Tran, Monohar Pilli, Michael Tolosa, Chandrashekar Gurramkonda
  • Publication number: 20170212048
    Abstract: An analyte sensing system is provided that utilizes separate and decoupled equilibrium and measurement chambers for improved sensitivity and stability. The system and method are particularly suited for monitoring of CO2 levels in oceans or other bodies of water.
    Type: Application
    Filed: September 30, 2011
    Publication date: July 27, 2017
    Inventors: Govind RAO, Yordan KOSTOV, Xudong GE, Leah TOLOSA, Hung LAM, Robert HENDERSON
  • Patent number: 9560974
    Abstract: A noninvasive remote parameter sensor and sensing method is provided that is particularly suited for the remote monitoring of skin temperature. The sensor and sensing method utilize luminescence-based sensors that are non-toxic and non-irritating to the skin. The sensor preferably utilizes one or more types of fluorophores that are embedded in a soft hydrogel. The sensor is illuminated with excitation light, and temperature is monitored by detecting and analyzing the emission light from the fluorophores. Because a soft hydrogel is used, the sensor can be gently wiped off the skin at the conclusion of temperature measurements.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: February 7, 2017
    Assignee: University of Maryland Baltimore County
    Inventors: Leah Tolosa, Hung Lam, Yordan Kostov, Steven M Falk, Govind Rao
  • Patent number: 9538944
    Abstract: A non-invasive gas analyte sensing and monitoring system and method is provided that is particularly applicable to transcutaneous monitoring of arterial blood gases in a mammal. The system and method relies on diffusion of the analyte to be measured into a diffusion chamber and remote sensing of the analyte in the diffusion chamber using optical chemical sensors and associated optoelectronics.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: January 10, 2017
    Assignee: University of Maryland Baltimore County
    Inventors: Govind Rao, Yordan Kostov, Xudong Ge, Leah Tolosa, Hyung Woo, Rose Viscardi
  • Publication number: 20160348048
    Abstract: A bioprocessing system for protein manufacturing is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The system can also be used for efficient on-demand production of any type of protein.
    Type: Application
    Filed: May 27, 2016
    Publication date: December 1, 2016
    Inventors: Govind RAO, Yordan KOSTOV, Leah TOLOSA, Hung LAM, Xudong GE, Douglas FREY, Virendra SINGH
  • Publication number: 20160222341
    Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
    Type: Application
    Filed: April 11, 2016
    Publication date: August 4, 2016
    Inventors: GOVIND RAO, YORDAN KOSTOV, LEAH TOLOSA, XUDONG GE, DOUGLAS FREY
  • Patent number: 9388373
    Abstract: A bioprocessing system for protein manufacturing is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The system can also be used for efficient on-demand production of any type of protein.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: July 12, 2016
    Assignee: University of Maryland Baltimore County
    Inventors: Govind Rao, Yordan Kostov, Leah Tolosa, Lam Hung, Xudong Ge, Douglas Frey, Virendra Singh
  • Publication number: 20150093775
    Abstract: An analyte sensing and monitoring system and method is provided that is particularly applicable to monitoring of analytes in cell cultures. The system and method relies on the initial diffusion rates of the analytes from the medium that contains the analytes being measured (e.g., cell culture) into a diffusion chamber that is inserted into the medium, and remote sensing of the analytes using an analyte sensing system that is coupled to the diffusion chamber.
    Type: Application
    Filed: July 2, 2014
    Publication date: April 2, 2015
    Inventors: Govind RAO, Xudong GE, Yordan KOSTOV, Madhubanti CHATTERJEE, Leah TOLOSA, Shaunak Dilip UPLEKAR, Manohar PILLI