Patents by Inventor Leben Tadesse

Leben Tadesse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CARTRIDGE WITH MIXING ZONE FOR ENDOTOXIN DETECTION
    Publication number: 20220323952
    Abstract: The present invention is directed to methods, compositions and devices useful for the detection and/or quantification of a microbial contaminant, including an endotoxin. In embodiments, cartridges are provided that suitably include dried compositions that are useful in absorbance-based assays and in combination with portable readers/devices.
    Type: Application
    Filed: August 13, 2020
    Publication date: October 13, 2022
    Inventors: Gerald SANDO, Candice STUMBAUGH, Adrian GRANDISON, Leben TADESSE, Puja SAWHNEY, Will HARRIS, Rupert BARTON
  • COAGULOGEN-FREE CLARIFIED LIMULUS AMEBOCYTE LYSATE
    Publication number: 20220267824
    Abstract: The present invention is related to compositions comprising clarified limulus amebocyte lysate (LAL), wherein the LAL is substantially free of coagulogen and methods of making such compositions. The invention further relates to a method of detecting an endotoxin in a sample using a chromogenic assay, the method comprising: (a) contacting the sample with a reagent comprising clarified LAL and a chromogenic substrate; and (b) measuring a chromogenic effect resulting from a change in the chromogenic substrate in the presence of endotoxin in the sample, wherein the LAL is substantially free of coagulogen. The invention also relates to kits comprising clarified LAL substantially free of coagulogen, and methods of making such.
    Type: Application
    Filed: May 5, 2022
    Publication date: August 25, 2022
    Inventors: Candice STUMBAUGH, Leben TADESSE, Karen LIN
  • Coagulogen-free clarified limulus amebocyte lysate and chromogenic assay of endotoxin
    Patent number: 11352656
    Abstract: The present invention is related to compositions comprising clarified limulus amebocyte lysate (LAL), wherein the LAL is substantially free of coagulogen and methods of making such compositions. The invention further relates to a method of detecting an endotoxin in a sample using a chromogenic assay, the method comprising: (a) contacting the sample with a reagent comprising clarified LAL and a chromogenic substrate; and (b) measuring a chromogenic effect resulting from a change in the chromogenic substrate in the presence of endotoxin in the sample, wherein the LAL is substantially free of coagulogen. The invention also relates to kits comprising clarified LAL substantially free of coagulogen, and methods of making such.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: June 7, 2022
    Inventors: Candice Stumbaugh, Leben Tadesse, Karen Lin
  • COAGULOGEN-FREE CLARIFIED LIMULUS AMEBOCYTE LYSATE
    Publication number: 20180208964
    Abstract: The present invention is related to compositions comprising clarified limulus amebocyte lysate (LAL), wherein the LAL is substantially free of coagulogen and methods of making such compositions. The invention further relates to a method of detecting an endotoxin in a sample using a chromogenic assay, the method comprising: (a) contacting the sample with a reagent comprising clarified LAL and a chromogenic substrate; and (b) measuring a chromogenic effect resulting from a change in the chromogenic substrate in the presence of endotoxin in the sample, wherein the LAL is substantially free of coagulogen. The invention also relates to kits comprising clarified LAL substantially free of coagulogen, and methods of making such.
    Type: Application
    Filed: January 11, 2018
    Publication date: July 26, 2018
    Inventors: Candice STUMBAUGH, Leben Tadesse, Karen LIN