Abstract: Certain embodiments are described that are directed to lead containing compositions including radiation absorption metals in combination with a polymeric material. In some aspects, a composition includes lead, optionally at least one additional heavy metal known to have shielding capability against ionizing radiation and at least one polymer, polymer blend or co-polymer. Sheets and articles including the compositions are also described.

Abstract: A coated steel includes a steel strip and an aluminum-based coating. The steel strip includes a free nitrogen concentration of greater than 40 parts per million (PPM). The aluminum-based coating is disposed on at least one surface of the steel strip.

Abstract: Provided herein are heteroaryl inhibitors of receptor tyrosine kinase effector (RAF), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of disease.

Abstract: Provided herein are inhibitors of cyclin-dependent kinases (CDKs), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

Abstract: Provided herein are heteroaryl inhibitors of receptor tyrosine kinase effector (RAF), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of disease.

Abstract: Provided herein are inhibitors of cyclin-dependent kinases (CDKs), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

Abstract: Provided herein are heteroaryl inhibitors of receptor tyrosine kinase effector (RAF), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of disease.

Abstract: Provided herein are heteroaryl inhibitors of receptor tyrosine kinase effector (RAF), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of disease.

Abstract: An electromechanical lock according to the present embodiments includes a lock extension and a blocking module having an interior region. A pivot bolt is mounted in the interior region for movement between a nominal position and an unsecured position. A first blocker is disposed in the interior region for movement between its nominal position and unblocking position. A second blocker is disposed in the interior region for movement between a nominal position and unblocking position. The pivot bolt, the first blocker, and the second blocker are biased to their respective nominal positions by springs.

Abstract: An electromechanical lock according to the present invention includes a lock extension and a blocking module having an interior region. A pivot bolt is mounted in the interior region for rotation about a rotation axis between a nominal position and an unsecured position. First and second blockers are also disposed in the interior for movement between their respective nominal positions and an unblocking position. The lock further includes an override disposed in the interior region for movement between a nominal position and an override position. The lock is in a secured condition when the first and second blockers and the override are in their respective nominal positions and an unsecured condition when the second blocker is in its unblocking position.

Abstract: An electromechanical lock according to the present invention includes a lock extension and a blocking module having an interior region. A pivot bolt is mounted in the interior region for rotation about a rotation axis between a nominal position and an unsecured position. First and second blockers are also disposed in the interior for movement between their respective nominal positions and an unblocking position. The lock further includes an override disposed in the interior region for movement between a nominal position and an override position. The lock is in a secured condition when the first and second blockers and the override are in their respective nominal positions and an unsecured condition when the second blocker is in its unblocking position.

Abstract: A tub spout assembly includes a tub spout. The tub spout includes a spout inlet and a spout outlet. A diverter assembly is carried by the tub spout. The diverter assembly includes a diverter inlet and a diverter outlet. A handle is rotatable from a first position to a second position and vice versa relative to the tub spout. A sealing element is coupled to the handle so as to rotate with the handle. In the first position the sealing element is disposed apart from the diverter outlet to permit water to flow through the tub spout assembly and exit the tub spout assembly via the spout outlet. In the second position the sealing element obscures the diverter outlet to inhibit water from flowing through the spout outlet of the tub spout assembly. A torsion spring biases the handle and the sealing element toward the first position.

Abstract: Personal care compositions comprising responsive particles. In one aspect, the responsive particle comprises: (1) a particle core having an interfacial surface, (2) a first polymer having a first property, and (3) a second polymer having a contrasting property. The first polymer and the second polymer are attached at different locations to the interfacial surface of the particle core. In another aspect, the responsive particle comprises: (1) a particle core having an interfacial surface, (2) at least one block co-polymer comprising a first block and a second block, wherein said first block has a first property and said second block has a second property, and (3) optionally, at least one other polymer having a third property. The block co-polymer and the optional other polymer (if present) are attached to the interfacial surface of the particle core, and at least one of the properties contrasts. The personal care compositions also comprise a dermatologically acceptable carrier.

Abstract: Personal care compositions, especially those personal care compositions in the form of an article that is a porous, dissolvable solid structure.

Abstract: A process that results in a flexible dissolvable porous solid article that can be used as a personal care composition or a fabric care composition.

Abstract: A process that results in a flexible dissolvable porous solid article that can be used as a personal care composition or a fabric care composition.

Abstract: The present invention relates to a dissolvable article in the form of a porous dissolvable solid structure, comprising from about 10% to about 50% water soluble polymer; from about 1% to about 25% plasticizer; from about 23% to about 75% surfactant; wherein the surfactants comprise one or more surfactants from Group I, wherein Group I includes anionic surfactants, and one or more surfactants from Group II, wherein Group II includes a surfactant selected from the group consisting of amphoteric, zwitterionic and combinations thereof; wherein the ratio of Group I to Group II surfactants is from about 5:95 to about 30:70; and wherein the dissolvable article has a density of from about 0.05 g/cm3 to about 0.40 g/cm3.

Abstract: New cleaning compositions including novel suds boosting and stabilization biopolymers containing alkoxy, anionic and nitrogen containing substitution are disclosed. In particular, cleaning compositions including suds boosting and stabilization biopolymers containing modified polysaccharides having alkoxy, anionic and nitrogen containing substitution and methods of forming the same are disclosed.

Abstract: A cleaning composition having from 0.05% to 30% by weight of surfactant and from 0.01% to 10% by weight of substituted starch, wherein the substituted starch has: a total degree of substitution in the range of from 0.001 to 0.6, a degree of substitution of anionic substituent in the range of from 0.001 to 0.04 and/or a degree of substation of nonionic substituent in the range of from 0.01 to 0.5, a degree of substitution of cationic substituent in the range of from 0 to 0.004, an average per weight molecular weight in the range of from 10 000 to 100 000 000 Daltons.

Abstract: Chemical compounds having structural formula I and physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases whose activity is inhibited by these compounds are involved in immunologic, hyperproliferative or angiogenic processes. Thus, these compounds can ameliorate disase states where angiogenesis or endothelial cell hyperproliferaton is a factor. These compounds can be used to treat cancer, hyperproliferative disorders, rheumatoid artheritis, disorders of the immune system, transplant rejection, and inflammatory disorders.