Patents by Inventor Lee D. Arnold

Lee D. Arnold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-heterocyclyl-substituted quinazoline derivatives, processes for their preparation and their use as anti-cancer agents
    Patent number: 5736534
    Abstract: This invention relates to certain 4-aminoquinazolines and the pharmaceutically acceptable salts and stereoisomers thereof, the formula whereof are described herein. The compounds are useful for the treatment of hyperproliferative diseases, particularly as anti-cancer agents.
    Type: Grant
    Filed: July 29, 1996
    Date of Patent: April 7, 1998
    Assignee: Pfizer Inc.
    Inventor: Lee D. Arnold
  • Syntheses of optically pure .alpha.-amino acids from 3-amino-2-oxetanone salts
    Patent number: 5200526
    Abstract: A process for the preparation of optically pure .alpha.-amino acids comprising the nucleophilic ring-opening of 3-amino-2-oxetanone salts. N-Protected serine .beta.-lactones are deprotected to form heretofore unknown 3-amino-2-oxetanone and its corresponding salts. In turn these previously unknown 3-amino-2-oxetanone salts may be used in the synthesis of other novel or rare stereochemically-pure free amino acids.
    Type: Grant
    Filed: October 23, 1990
    Date of Patent: April 6, 1993
    Assignee: The Governors of the University of Alberta
    Inventors: Lee D. Arnold, John C. Vederas
  • Polymer-supported alkyl azodicarboxylates and their use in Mitsunobu reactions
    Patent number: 4960832
    Abstract: A process for preparing an azodicarboxylate composition by chemically bonding dialkyl azodicarboxylates onto an insoluble solid polymer support. This process comprises the immobilization of hydrazodicarboxylates onto an insoluble solid polymer support and oxidizing the hydrazodicarboxylates to azodicarboxylates. The azodicarboxylate-polymer composition may be used in Mitsunobu-type reactions. After use in Mitsunobu-type reactions, the azodicarboxylate-polymer composition is recoverable and may be reused.
    Type: Grant
    Filed: April 27, 1988
    Date of Patent: October 2, 1990
    Assignee: The Governors of the University of Alberta
    Inventors: Lee D. Arnold, John C. Vederas