Abstract: A method for preparing uniform, spherical microspheres from an aqueous liquid sol feed stock, particularly of a fertile and/or fissionable nuclear fuel material. In the method, a jetstream of the liquid feed stock is provided, uniformly periodic varicose instabilities are induced in the jetstream, a concurrent, caoxial stripping flow of inert fluid is provided surrounding the jetstream to enhance the varicose instabilities in order to cause the uniform dispersion of the jetstream into uniform spherical droplets, and the uniform droplets are subsequently solidified.The present invention is directed to methods for manufacturing uniform microspheres of inorganic materials, and more particularly, is directed to such methods for generating large numbers of small microspheres by sol-gel processes and to methods which are particularly suitable in the preparation of uniform solid microspheres of fertile or fissionable nuclear fuel materials.