Patents by Inventor Lee F. Adams

Lee F. Adams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for producing polypeptides in mutants of bacillus cells
    Patent number: 5958728
    Abstract: The present invention relates to methods of producing a polypeptide, comprising: (a) cultivating a mutant of a Bacillus cell, wherein the mutant (i) comprises a first nucleic acid sequence encoding the polypeptide and a second nucleic acid sequence comprising a modification of at least one of the genes responsible for the biosynthesis or secretion of a surfactin or isoform thereof under conditions conducive for the production of the polypeptide and (ii) the mutant produces less of the surfactin or isoform thereof than the Bacillus cell when cultured under the same conditions; and (b) isolating the polypeptide from the cultivation medium. The present invention also relates to mutants of Bacillus cells and methods for producing the mutants.
    Type: Grant
    Filed: November 18, 1997
    Date of Patent: September 28, 1999
    Assignee: Novo NordiskBiotech, Inc.
    Inventors: Alan Sloma, David Sternberg, Lee F. Adams, Stephen Brown