Patents by Inventor Lee M. SILVER

Lee M. SILVER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11545235
    Abstract: In accordance with an embodiment of the invention, a system and method is provided for determining a probability of a progeny having one or more phenotypes Phj each associated with a single gene Qj. A score sip may be assigned to each allele hip at a plurality of genetic loci (i) in a haploid genome profile Hp of a parent (p). A plurality (Nj) of the alleles hkp (k=1, . . . , Nj) associated with the gene Qj may be identified. The scores sip may be mapped or indexed to gene-specific scores ?j,kp associated with gene Qj for the plurality of (Nj) alleles hkp. A probability may be computed for altering the gene product from gene Qj in a progeny of the parent (p) to be a function of the gene-specific scores ?j,kp.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: January 3, 2023
    Assignee: Ancestry.com DNA, LLC
    Inventors: Lee M. Silver, Adam Cohn, Ari Julian Silver
  • Publication number: 20210210161
    Abstract: Methods and systems for assessing the probabilities of the expression of one or more traits in progeny are described.
    Type: Application
    Filed: January 27, 2021
    Publication date: July 8, 2021
    Inventor: Lee M. Silver
  • Patent number: 10916332
    Abstract: Methods and systems for assessing the probabilities of the expression of one or more traits in progeny are described.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: February 9, 2021
    Assignee: Ancestry.com DNA, LLC
    Inventor: Lee M. Silver
  • Publication number: 20200097835
    Abstract: A method may include generating multiple virtual progenies from multiple first virtual gametes and multiple second virtual gametes. Each virtual progeny may combine one of the first virtual gametes and one of the second virtual gametes. A computing server may input, for each virtual progeny, data associated with the first virtual gamete of the virtual progeny to a machine learning model to determine a first variant-specific gene dysfunction score corresponding to a target allele site. The computing server may also input, for each virtual progeny, data associated with the second virtual gamete of the virtual progeny to the machine learning model to determine a second variant-specific gene dysfunction score corresponding to the target allele site. The computing server may derive, for each virtual progeny, a dysfunction likelihood score of the target allele site from the first variant-specific gene dysfunction score and the second variant-specific gene dysfunction score.
    Type: Application
    Filed: September 23, 2019
    Publication date: March 26, 2020
    Inventors: Ari Julian Silver, Velina Kozareva, Maxwell J. Silver, Nigel Delaney, Lee M. Silver
  • Publication number: 20180129778
    Abstract: Systems and methods of improved genetic mutation carrier screening may include, for a plurality of genetically similar genes in a reference genome, the plurality of genetically similar genes comprising a functional gene and a non-functional gene, masking the non-functional gene from the reference genome; aligning a plurality of functional gene reads and a plurality of non-functional gene reads of a patient's genetic sequence to the functional gene in the reference genome; tallying, at a first polymorphic locus-of-interest on each aligned read, a respective nucleotide type, wherein functional gene reads comprise a different nucleotide type than non-functional gene reads at the first polymorphic locus-of-interest; and calculating, based at least in part on a result of the tallying, a first gene ratio, wherein the first gene ratio indicates a first ratio of functional gene reads to non-functional gene reads.
    Type: Application
    Filed: May 27, 2016
    Publication date: May 10, 2018
    Applicant: GenePeeks, Inc.
    Inventors: Ari Julian SILVER, Lee M. SILVER, Jessica L. LARSON, Carlos BORROTO, Brett SPURRIER
  • Publication number: 20160314245
    Abstract: A device, system and method for predicting gene-dysfunction caused by a genetic mutation in the genome of an organism. A neural network may comprise multiple nodes respectively associated with multiple different gene-dysfunction metrics and multiple different confidence weights. The neural network may combine the multiple gene-dysfunction metrics according to the respective associated confidence weights to generate one or more likelihoods that a genetic mutation causes gene-dysfunction in organisms. In a training-phase, the neural network may be trained using an input data set including genetic mutations to generate new gene-dysfunction metrics and new associated confidence weights that optimize the neural network based on a cost factor.
    Type: Application
    Filed: April 22, 2016
    Publication date: October 27, 2016
    Inventors: Maxwell J. SILVER, Ari Julian SILVER, Lee M. SILVER, Nigel DELANEY
  • Publication number: 20150317432
    Abstract: In accordance with an embodiment of the invention, a system and method is provided for determining a probability of a progeny having one or more phenotypes Phj each associated with a single gene Qj. A score sip may be assigned to each allele hip at a plurality of genetic loci (i) in a haploid genome profile Hp of a parent (p). A plurality (Nj) of the alleles hkp (k=1, . . . , Nj) associated with the gene Qj may be identified. The scores sip may be mapped or indexed to gene-specific scores ?j,kp associated with gene Qj for the plurality of (Nj) alleles hkp. A probability may be computed for altering the gene product from gene Qj in a progeny of the parent (p) to be a function of the gene-specific scores ?j,kp.
    Type: Application
    Filed: December 5, 2013
    Publication date: November 5, 2015
    Inventors: Lee M. SILVER, Adam COHN, Ari Julian SILVER
  • Publication number: 20150088429
    Abstract: Methods and systems for assessing the probabilities of the expression of one or more traits in progeny are described.
    Type: Application
    Filed: June 2, 2014
    Publication date: March 26, 2015
    Applicant: GenePeeks, Inc.
    Inventor: Lee M. SILVER
  • Patent number: 8805620
    Abstract: Methods and systems for assessing the probabilities of the expression of one or more traits in progeny are described.
    Type: Grant
    Filed: October 20, 2010
    Date of Patent: August 12, 2014
    Assignee: GenePeeks, Inc.
    Inventor: Lee M. Silver
  • Patent number: 8620594
    Abstract: Methods and systems for assessing the probabilities of the expression of one or more traits in progeny are described.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: December 31, 2013
    Assignee: Genepeeks, Inc.
    Inventor: Lee M. Silver
  • Publication number: 20120322671
    Abstract: Methods and systems for assessing the probabilities of the expression of one or more traits in progeny are described.
    Type: Application
    Filed: August 22, 2012
    Publication date: December 20, 2012
    Applicant: GenePeeks, Inc.
    Inventor: Lee M. SILVER
  • Publication number: 20110124515
    Abstract: Methods and systems for assessing the probabilities of the expression of one or more traits in progeny are described.
    Type: Application
    Filed: October 20, 2010
    Publication date: May 26, 2011
    Inventor: Lee M. SILVER