Patents by Inventor Lee Rubin

Lee Rubin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Publication number: 20050085519
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
    Type: Application
    Filed: July 29, 2002
    Publication date: April 21, 2005
    Inventors: Lee Rubin, Oivin Guicherit, Stephen Price, Edward Boyd
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Publication number: 20050080138
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function by contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize hedgehog activity.
    Type: Application
    Filed: September 29, 2004
    Publication date: April 14, 2005
    Applicant: Curis, Inc.
    Inventors: Oivin Guicherit, Lee Rubin
  • Small organic molecule regulators of cell proliferation
    Publication number: 20050070578
    Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
    Type: Application
    Filed: September 18, 2002
    Publication date: March 31, 2005
    Inventors: Anthony Baxter, Edward Boyd, Maria Frank-Kamenetsky, Jeffery Porter, Stephen Price, Lee Rubin, John Stibbard
  • Angiogenesis-modulating compositions and uses
    Publication number: 20050054568
    Abstract: Hedgehog agonists and antagonists can be used to regulate angiogenesis, and to prevent angiogenesis driven pathologies. Furthermore, hedgehog agonists and antagonists have utility in modulating tissue repair and in the treatment of many forms of cancer.
    Type: Application
    Filed: August 29, 2003
    Publication date: March 10, 2005
    Inventors: Leona Ling, Michele Sanicola-Nadel, Karen Kotkow, Lee Rubin
  • Stem cell-based methods for identifying and characterizing agents
    Publication number: 20050019801
    Abstract: The present invention provides methods of identifying and/or characterizing agents that promote differentiation of stem cells to a particular differentiated cell type. The invention further provides methods of treating injuries and degenerative diseases by administering agents that promote the differentiation of stem cells to particular differentiated cell types.
    Type: Application
    Filed: June 4, 2004
    Publication date: January 27, 2005
    Applicant: Curis, Inc.
    Inventors: Lee Rubin, Karen Kotkow, Cheng-Jung Lai
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Publication number: 20050014796
    Abstract: The present invention makes available methods and reagents for inducing activation of a hedgehog pathway in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as a small molecule, in a sufficient amount to achieve a therapeutic result. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
    Type: Application
    Filed: December 9, 2003
    Publication date: January 20, 2005
    Applicant: Curis, Inc.
    Inventors: Anthony Baxter, Edward Boyd, Oivin Guicherit, Jeffrey Porter, Stephen Price, Lee Rubin
  • Agonists of hedgehog signaling pathways and uses related thereto
    Patent number: 6683108
    Abstract: The present invention makes available methods and reagents for inducing activation of a hedgehog pathway in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as a small molecule, in a sufficient amount to achieve a therapeutic result. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: January 27, 2004
    Assignee: Curis, Inc.
    Inventors: Anthony David Baxter, Edward Andrew Boyd, Oivin M. Guicherit, Jeffrey Porter, Stephen Price, Lee Rubin
  • Small organic molecule regulators of cell proliferation
    Patent number: 6683192
    Abstract: A compound represented in general formula (X) and (XI):
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: January 27, 2004
    Assignee: Curis, Inc.
    Inventors: Anthony David Baxter, Edward Andrew Boyd, Oivin M. Guicherit, Jeffrey Porter, Stephen Price, Lee Rubin, John Harry Alexander Stibbard
  • Small organic molecule regulators of cell proliferation
    Patent number: 6613798
    Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: September 2, 2003
    Assignee: Curis, Inc.
    Inventors: Jeffrey Porter, Oivin M. Guicherit, Lee Rubin, Anthony David Baxter, Edward Andrew Boyd, Stephen Price
  • Progenitor cells and methods and uses related thereto
    Patent number: 6610535
    Abstract: The present invention relates to a substantially pure population of viable pancreatic progenitor cells, and methods for isolating such cells. The present invention further concerns certain therapeutic uses for such progenitor cells, and their progeny.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: August 26, 2003
    Assignee: ES Cell International Pte Ltd.
    Inventors: Kuanghui Lu, Kevin Pang, Lee Rubin
  • Small organic molecule regulators of cell proliferation
    Publication number: 20030139457
    Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
    Type: Application
    Filed: September 17, 2002
    Publication date: July 24, 2003
    Applicant: Curis, Inc.
    Inventors: Anthony David Baxter, Edward Andrew Boyd, Maria Frank-Kamenetsky, Oivin Guicherit, Jeffery Porter, Stephen Price, Lee Rubin, John Harry Alexander Stibbard
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Patent number: 6552016
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: April 22, 2003
    Assignee: Curis, Inc.
    Inventors: Anthony David Baxter, Edward Andrew Boyd, Oivin M. Guicherit, Stephen Price, Lee Rubin
  • Small organic molecule regulators of cell proliferation
    Publication number: 20020198236
    Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
    Type: Application
    Filed: September 26, 2001
    Publication date: December 26, 2002
    Inventors: Anthony David Baxter, Edward Andrew Boyd, Oivin M. Guicherit, Jeffery Porter, Stephen Price, Lee Rubin, John Harry Alexander Stibbard