Patents by Inventor Lee Spence

Lee Spence has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10913703
    Abstract: The present invention relates to purification methods of pleuromutilin (I) by means of crystallisation and/or recrystallisation. The process according to the present invention is carried out in the presence of i-propylacetate.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: February 9, 2021
    Assignee: NABRIVA THERAPEUTICS GMBH
    Inventors: Werner Heilmayer, Lee Spence, Peter Hinsmann
  • Publication number: 20200231529
    Abstract: The present invention relates to purification methods of pleuromutilin (I) by means of crystallisation and/or recrystallisation. The process according to the present invention is carried out in the presence of i-propylacetate.
    Type: Application
    Filed: February 9, 2018
    Publication date: July 23, 2020
    Inventors: Werner HEILMAYER, Lee SPENCE, Peter HINSMANN
  • Patent number: 9188260
    Abstract: An O-ring has a flange which includes a plurality of slots, such that, when inserted into an annular groove of a pipe fitting before crimping, the slots allow the flow of fluid therethrough, such that an installation would not pass pressure tests until such time as a proper crimp has been made. Such a design allows the use of conventional push-on pipe connections by utilizing a unique O-ring seal which works in conjunction with standard push-on crimp-type pipe fittings and conventional crimping tools for subsequently sealing the connection. The O-ring is either circular or elliptical in cross section and the slots define equally spaced annular segments.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: November 17, 2015
    Assignee: NIBCO Inc.
    Inventor: Scott Lee Spence
  • Patent number: 9120727
    Abstract: Process for the preparation of a compound of formula I in the form of a single stereoisomer in crystalline form, comprising deprotecting the amine group in a compound of formula IIa or in a mixture of a compound of formula IIa with a compound of formula IIb and isolating a compound of formula I from the reaction mixture; compounds and salts of compounds of formula I in crystalline form; pharmaceutical compositions comprising such salts; processes for the preparation of intermediates and intermediates in a process for the preparation of a compound of formula I.
    Type: Grant
    Filed: May 23, 2011
    Date of Patent: September 1, 2015
    Assignee: NABRIVA THERAPEUTICS AG
    Inventors: Rosemarie Riedl, Werner Heilmayer, Lee Spence
  • Patent number: 8987498
    Abstract: A compound of formula wherein PROT is an amine protecting group and PROT? is hydrogen; or PROT and PROT? together with the nitrogen atom to which they are attached form a heterocyclic ring as an amine protecting group, and PROT? is a thiol protecting group, processes for its production, intermediates in their production and production of intermediates in stereoisomerically pure form, and their use for the production of pharmaceutically active compounds.
    Type: Grant
    Filed: May 23, 2011
    Date of Patent: March 24, 2015
    Assignee: Nabriva Therapeutics AG
    Inventors: Rosemarie Riedl, Werner Heilmayer, Lee Spence, Atchyuta Rama Chandra Murty Bulusu
  • Publication number: 20130079400
    Abstract: Process for the preparation of a compound of formula I in the form of a single stereoisomer in crystalline form, comprising deprotecting the amine group in a compound of formula IIa or in a mixture of a compound of formula IIa with a compound of formula IIb and isolating a compound of formula I from the reaction mixture; compounds and salts of compounds of formula I in crystalline form; pharmaceutical compositions comprising such salts; processes for the preparation of intermediates and intermediates in a process for the preparation of a compound of formula I.
    Type: Application
    Filed: May 23, 2011
    Publication date: March 28, 2013
    Applicant: Nabriva Therapeutics AG
    Inventors: Rosemarie Riedl, Werner Heilmayer, Lee Spence
  • Publication number: 20130072711
    Abstract: A compound of formula wherein PROT is an amine protecting group and PROT? is hydrogen; or PROT and PROT? together with the nitrogen atom to which they are attached form a heterocyclic ring as an amine protecting group, and PROT? is a thiol protecting group, processes for its production, intermediates in their production and production of intermediates in stereoisomerically pure form, and their use for the production of pharmaceutically active compounds.
    Type: Application
    Filed: May 26, 2010
    Publication date: March 21, 2013
    Applicant: NABRIVA THERAPEUTICS AG
    Inventors: Rosemarie Riedl, Werner Heilmayer, Lee Spence, Atchyuta Rama Chandra Murty Bulusu
  • Publication number: 20100025992
    Abstract: An O-ring has a flange which includes a plurality of slots, such that, when inserted into an annular groove of a pipe fitting before crimping, the slots allow the flow of fluid therethrough, such that an installation would not pass pressure tests until such time as a proper crimp has been made. Such a design allows the use of conventional push-on pipe connections by utilizing a unique O-ring seal which works in conjunction with standard push-on crimp-type pipe fittings and conventional crimping tools for subsequently sealing the connection. The O-ring is either circular or elliptical in cross section and the slots define equally spaced annular segments.
    Type: Application
    Filed: July 30, 2009
    Publication date: February 4, 2010
    Applicant: NIBCO Inc.
    Inventor: Scott Lee Spence
  • Patent number: 6950777
    Abstract: A system and method is provided for analyzing data obtained during manufacture of a web of paper or paperboard on a machine. The system comprises a computer including a database module, a statistical analysis module, and a processor for executing the modules. The database module contains measurements of quality parameters obtained from the web during manufacture. The statistical analysis module is executed by the processor to analyze the measurement data and estimate a target shift in at least one quality parameter that could be made if the controllable variations were removed. The target shift can be transformed into an economic amount (i.e., dollar value) by the statistical analysis module to assist the mill operator with making well informed, economic based decisions. The system further includes a diagnostic module capable of automatically identifying machine parameters that correlate to quality parameters that caused the web to fall outside the desired quality specifications.
    Type: Grant
    Filed: July 29, 2003
    Date of Patent: September 27, 2005
    Assignee: Voith Paper Inc.
    Inventors: David Andrew Lilburn, Christopher Lee Spence
  • Patent number: 6354723
    Abstract: A footrest for a motorcycle, such footrest having a hollow body containing a light source. A lens extends substantially over the entire surface of an opening of the housing for providing high visibility to oncoming traffic. A lens cover protects the lens from impact.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: March 12, 2002
    Inventor: Wendell Lee Spence
  • Patent number: 5895185
    Abstract: This invention is an automatic boat to trailer latch permitting a one-person operation by a person either in the boat or in the water behind it, in light or in darkness, which allows that person to align the boat's bow with the latching mechanism, without sacrificing control of the boat.
    Type: Grant
    Filed: July 28, 1997
    Date of Patent: April 20, 1999
    Inventor: Wendell Lee Spence
  • Patent number: 5879114
    Abstract: This invention is an automatic boat to trailer latch permitting a one-person operation by a person either in the boat or in the water behind it, in light or in darkness, which allows that person to align the boat's bow with the latching mechanism, without sacrificing control of the boat.
    Type: Grant
    Filed: July 28, 1997
    Date of Patent: March 9, 1999
    Inventor: Wendell Lee Spence