Patents by Inventor Lee Spence
Lee Spence has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10913703Abstract: The present invention relates to purification methods of pleuromutilin (I) by means of crystallisation and/or recrystallisation. The process according to the present invention is carried out in the presence of i-propylacetate.Type: GrantFiled: February 9, 2018Date of Patent: February 9, 2021Assignee: NABRIVA THERAPEUTICS GMBHInventors: Werner Heilmayer, Lee Spence, Peter Hinsmann
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Publication number: 20200231529Abstract: The present invention relates to purification methods of pleuromutilin (I) by means of crystallisation and/or recrystallisation. The process according to the present invention is carried out in the presence of i-propylacetate.Type: ApplicationFiled: February 9, 2018Publication date: July 23, 2020Inventors: Werner HEILMAYER, Lee SPENCE, Peter HINSMANN
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Patent number: 9188260Abstract: An O-ring has a flange which includes a plurality of slots, such that, when inserted into an annular groove of a pipe fitting before crimping, the slots allow the flow of fluid therethrough, such that an installation would not pass pressure tests until such time as a proper crimp has been made. Such a design allows the use of conventional push-on pipe connections by utilizing a unique O-ring seal which works in conjunction with standard push-on crimp-type pipe fittings and conventional crimping tools for subsequently sealing the connection. The O-ring is either circular or elliptical in cross section and the slots define equally spaced annular segments.Type: GrantFiled: July 30, 2009Date of Patent: November 17, 2015Assignee: NIBCO Inc.Inventor: Scott Lee Spence
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Patent number: 9120727Abstract: Process for the preparation of a compound of formula I in the form of a single stereoisomer in crystalline form, comprising deprotecting the amine group in a compound of formula IIa or in a mixture of a compound of formula IIa with a compound of formula IIb and isolating a compound of formula I from the reaction mixture; compounds and salts of compounds of formula I in crystalline form; pharmaceutical compositions comprising such salts; processes for the preparation of intermediates and intermediates in a process for the preparation of a compound of formula I.Type: GrantFiled: May 23, 2011Date of Patent: September 1, 2015Assignee: NABRIVA THERAPEUTICS AGInventors: Rosemarie Riedl, Werner Heilmayer, Lee Spence
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Patent number: 8987498Abstract: A compound of formula wherein PROT is an amine protecting group and PROT? is hydrogen; or PROT and PROT? together with the nitrogen atom to which they are attached form a heterocyclic ring as an amine protecting group, and PROT? is a thiol protecting group, processes for its production, intermediates in their production and production of intermediates in stereoisomerically pure form, and their use for the production of pharmaceutically active compounds.Type: GrantFiled: May 23, 2011Date of Patent: March 24, 2015Assignee: Nabriva Therapeutics AGInventors: Rosemarie Riedl, Werner Heilmayer, Lee Spence, Atchyuta Rama Chandra Murty Bulusu
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Publication number: 20130079400Abstract: Process for the preparation of a compound of formula I in the form of a single stereoisomer in crystalline form, comprising deprotecting the amine group in a compound of formula IIa or in a mixture of a compound of formula IIa with a compound of formula IIb and isolating a compound of formula I from the reaction mixture; compounds and salts of compounds of formula I in crystalline form; pharmaceutical compositions comprising such salts; processes for the preparation of intermediates and intermediates in a process for the preparation of a compound of formula I.Type: ApplicationFiled: May 23, 2011Publication date: March 28, 2013Applicant: Nabriva Therapeutics AGInventors: Rosemarie Riedl, Werner Heilmayer, Lee Spence
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Publication number: 20130072711Abstract: A compound of formula wherein PROT is an amine protecting group and PROT? is hydrogen; or PROT and PROT? together with the nitrogen atom to which they are attached form a heterocyclic ring as an amine protecting group, and PROT? is a thiol protecting group, processes for its production, intermediates in their production and production of intermediates in stereoisomerically pure form, and their use for the production of pharmaceutically active compounds.Type: ApplicationFiled: May 26, 2010Publication date: March 21, 2013Applicant: NABRIVA THERAPEUTICS AGInventors: Rosemarie Riedl, Werner Heilmayer, Lee Spence, Atchyuta Rama Chandra Murty Bulusu
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Publication number: 20100025992Abstract: An O-ring has a flange which includes a plurality of slots, such that, when inserted into an annular groove of a pipe fitting before crimping, the slots allow the flow of fluid therethrough, such that an installation would not pass pressure tests until such time as a proper crimp has been made. Such a design allows the use of conventional push-on pipe connections by utilizing a unique O-ring seal which works in conjunction with standard push-on crimp-type pipe fittings and conventional crimping tools for subsequently sealing the connection. The O-ring is either circular or elliptical in cross section and the slots define equally spaced annular segments.Type: ApplicationFiled: July 30, 2009Publication date: February 4, 2010Applicant: NIBCO Inc.Inventor: Scott Lee Spence
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Patent number: 6950777Abstract: A system and method is provided for analyzing data obtained during manufacture of a web of paper or paperboard on a machine. The system comprises a computer including a database module, a statistical analysis module, and a processor for executing the modules. The database module contains measurements of quality parameters obtained from the web during manufacture. The statistical analysis module is executed by the processor to analyze the measurement data and estimate a target shift in at least one quality parameter that could be made if the controllable variations were removed. The target shift can be transformed into an economic amount (i.e., dollar value) by the statistical analysis module to assist the mill operator with making well informed, economic based decisions. The system further includes a diagnostic module capable of automatically identifying machine parameters that correlate to quality parameters that caused the web to fall outside the desired quality specifications.Type: GrantFiled: July 29, 2003Date of Patent: September 27, 2005Assignee: Voith Paper Inc.Inventors: David Andrew Lilburn, Christopher Lee Spence
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Patent number: 6354723Abstract: A footrest for a motorcycle, such footrest having a hollow body containing a light source. A lens extends substantially over the entire surface of an opening of the housing for providing high visibility to oncoming traffic. A lens cover protects the lens from impact.Type: GrantFiled: December 22, 1999Date of Patent: March 12, 2002Inventor: Wendell Lee Spence
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Patent number: 5895185Abstract: This invention is an automatic boat to trailer latch permitting a one-person operation by a person either in the boat or in the water behind it, in light or in darkness, which allows that person to align the boat's bow with the latching mechanism, without sacrificing control of the boat.Type: GrantFiled: July 28, 1997Date of Patent: April 20, 1999Inventor: Wendell Lee Spence
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Patent number: 5879114Abstract: This invention is an automatic boat to trailer latch permitting a one-person operation by a person either in the boat or in the water behind it, in light or in darkness, which allows that person to align the boat's bow with the latching mechanism, without sacrificing control of the boat.Type: GrantFiled: July 28, 1997Date of Patent: March 9, 1999Inventor: Wendell Lee Spence