Patents by Inventor Lee Te-Wei

Lee Te-Wei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of copper 2-alkoxyisobutylisonitrile complexes and .sup.99m Tc labelling of 2-alkoxyisobutylisonitrile
    Patent number: 5346995
    Abstract: A new method for synthesizing 2-alkoxyisobutylisonitrile is provided in which isobutylene is used as the starting material. The haloalkoxylation of isobutylene in alcohol medium gives 2-alkoxyisobutylhalide which is then converted to 2-alkoxyisobutylamine. In the basic condition, the reaction of 2-alkoxyisobutylamine with chloroform produces 2-alkoxyisobutylisonitrile. The synthesis process contains three steps by which a higher yield is achieved. 2-Alkoxyisobutylisonitrile is labelled with technetium-99m by exchange labelling of stable tetrakis(2-alkoxyisobutylisonitrile)copper(I) complex. Tetrakis(2-alkoxyisobutylisonitrile)copper(I) complex can be prepared by the exchange of acetonitrile molecules in tetrakis(acetonitrile)copper(I) complex with isonitrile ligands.
    Type: Grant
    Filed: January 13, 1993
    Date of Patent: September 13, 1994
    Assignee: Institute of Nuclear Energy Research
    Inventors: Lee Te-Wei, Ting Gann, Su Chang-Shinn, Chyi Shyh-Yi
  • Method for synthesis and .sup.99m C labelling of 2-alkoxyisobutylisonitrile
    Patent number: 5210270
    Abstract: A new method for synthesizing 2-alkoxyisobutylisonitrile is provided in which isobutylene is used as the starting material. The haloalkoxylation of isobutylene in alcohol medium gives 2-alkoxyisobutylhalide which is then converted to 2-alkoxyisobutylamine. In the basic condition, the reaction of 2-alkoxyisobutylamine with chloroform produces 2-alkoxyisobutylisonitrile. The synthesis process contains three steps by which a higher yield is achieved. 2-Alkoxyisobutylisonitrile is labelled with technetium-99m by exchange labelling of stable tetrakis(2-alkoxyisobutylisonitrile)copper(I) complex. Tetrakis(2-alkoxyisobutylisonitrile)copper(I) complex can be prepared by the exchange of acetonitrile molecules in tetrakis(acetonitrile)copper(I) complex with isonitrile ligands.
    Type: Grant
    Filed: November 25, 1991
    Date of Patent: May 11, 1993
    Assignee: Institute of Nuclear Energy Research
    Inventors: Lee Te-Wei, Ting Gann, Su Chang-Shinn, Chyi Shyh-Yi