Patents by Inventor LeeAnn Rooney

LeeAnn Rooney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fluorescent detection of in vitro translated protein on a solid surface
    Patent number: 9188592
    Abstract: Disclosed herein are methods and kits useful in the detection of protein folding and in the identification of compounds that promote proper protein folding. In one example approach, fluorophores and a protein tag are incorporated into a nascent polypeptide within a ribosome-nascent-chain complex during cell free translation and the resulting labeled ribosome-nascent-chain complex is conjugated to a solid surface via the tag. Fluorescence imaging via FRET is then preformed to assess the folding state of the ribosome-nascent-chain complex under a variety of conditions.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: November 17, 2015
    Assignee: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: William Skach, LeeAnn Rooney, Hideki Shishido, Zhongying Yang
  • FLUORESCENT DETECTION OF IN VITRO TRANSLATED PROTEIN ON A SOLID SURFACE
    Publication number: 20140099724
    Abstract: Disclosed herein are methods and kits useful in the detection of protein folding and in the identification of compounds that promote proper protein folding. In one example approach, fluorophores and a protein tag are incorporated into a nascent polypeptide within a ribosome-nascent-chain complex during cell free translation and the resulting labeled ribosome-nascent-chain complex is conjugated to a solid surface via the tag. Fluorescence imaging via FRET is then preformed to assess the folding state of the ribosome-nascent-chain complex under a variety of conditions.
    Type: Application
    Filed: October 9, 2013
    Publication date: April 10, 2014
    Applicant: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: William Skach, LeeAnn Rooney, Hideki Shishido, Zhongying Yang