Abstract: Described herein are compounds of Formula I, wherein the variables are defined herein, their use as HSD17B13 inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, NAFLD and NASH.

Abstract: A rolling device and a measuring device are disclosed. A rolling assembly in the rolling device is movably mounted on a bracket in a first direction (a) parallel to a working surface, and when a member to be rolled is placed on the working surface, the rolling assembly provides a rolling pressure to the member to be rolled. In a rolling process, the rolling assembly moves in the first direction (a), so as to be capable of ensuring that the rolling pressure applied to the member to be rolled is constant and always perpendicular to the member to be rolled, that is, ensuring that the rolling pressure remains constant, thereby reducing the influence of external factors on the rolling process and improving the accuracy of a measurement result.

Abstract: The present disclosure provides a method comprising obtaining gas data of a gas user continuously, and storing the gas data into a storage unit; predicting a probability of full storage of the storage unit within a preset future time period based on a historical data increment of the storage unit; in response to the probability of full storage meeting a preset probability condition: obtaining the gas data of the gas user within the preset time period from the storage unit; determining an upload demand degree of the gas data based on the gas data; and in response to the upload demand degree meeting a preset condition, transmitting the gas data within the preset time period to a smart gas management platform based on a smart gas object platform at a target upload time point of a smart gas meter of the gas user.

Abstract: The present invention discloses a right-angle turning method for small-diameter TBM exploration adit excavation and belongs to the field of geological exploration of water conservancy and hydropower projects.

Abstract: A device for measuring length and center of mass of conical workpiece, including an inner frame, an outer frame, a base plate, two laser displacement sensors and a plurality of weighing mechanisms. The inner frame is rotatably connected with the outer frame through a pin shaft. A bottom surface of the conical workpiece can be fixedly connected with an inner bottom surface of the inner frame. The base plate is removably arranged on the inner frame, and abuts against a top of the conical workpiece. The base plate is perpendicular to an axis of the conical workpiece. The laser displacement sensors are fixedly arranged at a position of the inner frame below the top of the conical workpiece. The weighing mechanisms are provided at a bottom of the outer frame, and can bear the inner frame, the outer frame and the conical workpiece.

Abstract: An audio encoding and decoding method and a related apparatus are provided. The audio encoding method includes: determining a channel combination scheme for a current frame; when the channel combination scheme for the current frame is different from a channel combination scheme for a previous frame, performing segmented time-domain downmix processing on left and right channel signals in the current frame based on the channel combination scheme for the current frame and the channel combination scheme for the previous frame, to obtain a primary channel signal and a secondary channel signal in the current frame; and encoding the obtained primary channel signal and secondary channel signal in the current frame.

Abstract: A charging management method for multiple battery packs comprises determining a target charging current of each battery pack according to a sampled temperature of each battery pack and a sampled voltage of each battery pack; calculating a difference between the sum of the target charging currents of various battery packs and the sum of sampled charging currents of the various battery packs, to obtain a total PI adjustment value; sending the total PI adjustment value to a charging device, to enable the charging device to adjust a total charging current according to the total PI adjustment value; determining a charging current of each battery pack according to the sampled charging current of each battery pack and the total charging current, and determining a charging voltage of each battery pack according to the sampled voltage of each battery pack.

Abstract: A compound composition for improving bone health and preparation and application thereof are provided. The compound composition is prepared by combining a traditional Chinese medicine extract with chicken cartilage collagen, magnesium, vitamin K2 and vitamin D3. The compound composition overcomes the food safety risk of the existing osteoporosis preventive drugs by adding the traditional Chinese medicine extract for improving osteoporosis and promoting bone health. And the compound composition disclosed can be used as a dietary supplement or health food raw material for preventing or treating osteoporosis. Therefore, the compound composition disclosed is suitable for promotion and application.

Abstract: The present disclosure embodiment may disclose a glasses including a glasses frame and two speakers. The glasses frame may include a glasses rim and two glasses temples. The two glasses temples may be rotatably connected to the glasses rim, respectively. The two speakers may include an earphone core. The two speakers may be connected to the two glasses temples via hinge components of the two glasses temples, respectively. The hinge components may be rotatable to change a position of each of the speakers relative to connected one of the glasses temples. The glasses temple may include a circuit component or a battery to drive the earphone core to vibrate to generate a sound. In the present disclosure, the glasses rim and the glasses temple may be connected through a rotating shaft, thereby protecting the connection wire in the glasses and extending the life of the connection wire.

Abstract: A hydraulic-electric coupling driven multi-actuator system and control method are provided. The system comprises one or more hydraulic-electric hybrid driven actuators, first inverters, control valves, centralized hydraulic units and control units, wherein each hydraulic-electric hybrid driven actuator is correspondingly connected with one first inverter and one control valve; the centralized hydraulic units are connected with the control valves and configured to supply oil for the hydraulic-electric hybrid driven actuators and to perform power compensation; and the control units are respectively connected with the hydraulic-electric hybrid driven actuators, and each control unit is configured to control output torque of a first motor of the corresponding hydraulic-electric hybrid driven actuator based on pressure information of the hydraulic-electric hybrid driven actuator, such that pressure of driving cavities of the hydraulic-electric hybrid driven actuators is equal.

Abstract: An open earphone includes an acoustic driver for generating two sounds with opposite phases; a housing for accommodating the acoustic driver; and a suspension structure for fixing the housing in a position near an ear of a user without blocking an ear canal of the user. The housing is provided with two sound holes for outputting each of the two sounds with opposite phases. The housing includes a body and a baffle. The body defines a first cavity for housing the acoustic driver. The baffle is connected to the body and extended in a direction toward the ear canal of the user, and defines a second cavity with the auricle of the user. The two sound holes are disposed respectively inside and outside the second cavity.

Abstract: A foldable display device may have housing portions coupled by a hinge. A flexible display may overlap the hinge. The hinge may have portions that rotate relative to each other about rotational axes that lie above the hinge to help reduce stress to the display. The hinge may have gear plates with interlocked teeth that synchronize rotational movement between left and right halves of the hinge. The hinge may also have asymmetric friction clips that impose different amounts of rotational friction to the hinge depending on the direction of rotation of the hinge.

Abstract: An open-ear Bluetooth® earphone includes an earphone body and a support frame. The support frame is configured to be plugged into a cavum concha of a wearer. The earphone body is provided with an audio source, and the support frame is installed on the earphone body and corresponds to the audio source. When in use, the support frame is configured to be firmly plugged into the cavum concha of the wearer to allow the earphone body to be worn on the ear of the wearer. The audio source corresponds to the ear canal of the wearer through the support frame, so that the sound emitted from the audio source is transmitted into the ear canal through the support frame. The audio source is directly opposite of the ear canal through the support frame to shorten the distance between the audio source and the ear canal.

Abstract: An electrode for an electrochemical cell includes an electroactive material and an electrolyte. The electroactive material is represented by: xLi2MnO3·(1?x)LiMO2 where M is a transition metal selected from the group consisting of: nickel (Ni), manganese (Mn), cobalt (Co), aluminum (Al), iron (Fe), and combinations thereof and 0.01?x?0.99. The electrolyte includes a solvent system that includes a solvent and greater than or equal to about 1 vol. % to less than or equal to about 90 vol. % of a diluent. The diluent includes tetrafluoropropyl ether (TTE), 2,2,2-trifluoroethanol (TFE), or a combination of tetrafluoropropyl ether (TTE) and 2,2,2-trifluoroethanol (TFE).

Abstract: An electrode for an electrochemical cell includes an electroactive material and an electrolyte that includes a lithium-salt additive and a solvent. The electroactive material is represented by: xLi2MnO3·(1?x)LiMO2 where M is a transition metal selected from the group consisting of: nickel (Ni), manganese (Mn), cobalt (Co), aluminum (Al), iron (Fe), and combinations thereof and 0.01?x?0.99. The solvent is selected from the group consisting of: ethylene carbonate (EC), fluoroethylene carbonate (FEC), dimethyl carbonate (DMC), diethyl carbonate (DEC), ethylmethylcarbonate (EMC), ethylmethylcarbonate (EMC), ethylene carbonate (EC), propylene carbonate (PC), vinyl ethylene carbonate (VEC), tetramethylene sulfone (TMS), ethyl methyl sulfone (EMS), acetonitrile (AN), butyronitrile (BN), and combinations thereof. The electrolyte includes between about 0.001 wt. % and about 10 wt. % of the lithium-salt additive and has an overall salt concentration between about 0.1 mol/L and about 10 mol/L.

Abstract: The present disclosure provides methods, devices and systems for route deviation quantification and vehicular route learning based thereon. In some examples, there is provided a method for route deviation quantification of a suggested route. The method comprises: obtaining a ground truth route based on a filtered trajectory, the filtered trajectory including an inferred location of origin and an inferred location of destination; obtaining a suggested route generated based on the inferred location of origin and the inferred location of destination; quantifying a deviation of the suggested route from the ground truth route by calculating an off course ratio based on a combined length of road segments in the suggested route that are matched to corresponding road segments in the ground truth route and a combined length of road segments in the ground truth route.

Abstract: A modeling method and a modeling system for an optical proximity correction (OPC) model and an OPC method based on the OPC model are disclosed. During the creation of the OPC model, variables related to pattern density of a test pattern are added. As a result, the created innovative OPC model includes a mapping relationship between a critical dimension of the pattern and the pattern density-related variables. After that, the OPC model is used to determine critical dimension (CD) distortion of the test pattern in environments with different pattern densities, which is then compared with a designed CD for the test pattern, thereby determining an OPC correction amount for the test pattern. In this way, accurate OPC correction can be achieved, resulting in an improved process window for the layout and effectively increased yield of the product.

Abstract: An integrated device and method for enrichment, purification and separation of microplastics in a secondary effluent are provided. This integrated device comprises a micro-spray system and a filtering system with multi-stage filtering units, and marked screen meshes were installed in each filtering unit. The microplastics in secondary effluent are enriched on the surface of the marked screen meshes through the retaining effect. Then, lower concentration of alkali, acid or oxidant combined with the heat treatment to weaken the interaction forces between the inorganic/organic foulants and the enriched microplastic. On this basis, the micro-spray system was used to rinse the multistage filtration system, which generated shear force to carry away the foulants on the surfaces of the enriched microplastics, thereby achieving the purification and separation of microplastics synchronously. These are performed in the marked screen meshes, in which the microplastic are not subject to any path transfer or loss.

Abstract: A brazing joint, a brazing method, and a device for promoting solder rheology and gas overflow are provided. The brazing joint includes a first base metal, a second base metal, and a brazing seam located therebetween. The brazing seam is formed by filling a solder in a gap formed by welding surfaces of the first and the second base metal and melting it to connect the first and the second base metal. The brazing seam is a concave-shaped brazing seam. The gap defines a first distance and a second distance, the first distance is located at an edge of the gap, the second distance is located at the edge or an inside of the gap, the first distance is greater than the second distance, and a curved surface is formed between the location of the first distance and the location of the second distance for transition.

Abstract: The present disclosure mainly relates to a headphone. The headphone may include a supporting assembly and a core module connected with the supporting assembly. The supporting assembly may be configured to support the core module to be worn at a wearing position. The core module may include a core housing, a transducer device, and a vibration panel. The transducer device may be provided in a accommodating cavity of the core housing, and the vibration panel may be connected with the transducer device and configured to transmit a mechanical vibration generated by the transducer device to a user.