Abstract: A method for radiation therapy treatment planning includes: a) defining a decision variable search space by projecting an initial seed point onto a pareto front, where the pareto front and decision variable search space are defined in the same coordinate space; b) projecting search points in the decision variable search space to the pareto front using a one-dimensional search algorithm to produce projected points on the pareto front; c) updating the search points by performing a gradient-free optimization that evaluates a treatment planning scoring function at the projected points on the pareto front; and d) repeating steps (b), (c) to search within the decision variable search space until a convergence criterion is satisfied, thereby producing a pareto optimal and clinically acceptable treatment plan.

Abstract: A method for tomographic imaging comprising acquiring [200] a set of one or more 2D projection images [202] and reconstructing [204] a 3D volumetric image [216] from the set of one or more 2D projection images [202] using a residual deep learning network comprising an encoder network, a transform module and a decoder network, wherein the reconstructing comprises: transforming [206] by the encoder network the set of one or more 2D projection images [202] to 2D features [208]; mapping [210] by the transform module the 2D features [208] to 3D features [212]; and generating [214] by the decoder network the 3D volumetric image from the 3D features [212]. Preferably, the encoder network comprises 2D convolution residual blocks and the decoder network comprises 3D blocks without residual shortcuts within each of the 3D blocks.

Abstract: A method for quantitative magnetic resonance imaging (MRI) includes [800] performing an MRI scan using a conventional pulse sequence to obtain a qualitative MR image; and [802] applying the qualitative MR image as input to a deep convolutional neural network (CNN) to produce a quantitative magnetic resonance (MR) relaxation parametric map. The qualitative MR image is the only image input to the deep neural network to produce the quantitative MR relaxation parametric map. The conventional pulse sequence may be a Spoiled Gradient Echo sequence, a Fast Spin Echo sequence, a Steady-State Free Precession sequence, or other sequence that is commonly used in current clinical practice.

Abstract: The present disclosure describes a Mtu ?I-CM intein variant containing one or more mutations or a biologically active fragment thereof, and a method for producing and purifying a molecule of interest using the intein variant. Further described are isolated fusion proteins comprising the intein variant and a tag and a molecule of interest. Also described are expression systems for expressing the intein variant as well as polypeptide screening methods employing the intein variant.

Abstract: In a method for enriching and separating an anaerobic fiber-degrading bacterium on the basis of cellulosic magnetic nanoparticles, the cellulosic magnetic nanoparticles are prepared by coating cellulose on the surface of a magnetic nanomaterial. Bacteria attach to the cellulosic magnetic nanoparticles. Anaerobic fiber-degrading bacteria degrade the cellulose and then detach from the cellulosic magnetic nanoparticles, and the anaerobic fiber-degrading bacteria are obtained by means of separation using a magnet. The magnetic nano-separation technology can be used as a new technology to efficiently separate anaerobic fiber-degrading bacteria.

Abstract: A ratio of reversible electroporation and irreversible electroporation may be controlled by selecting a symmetric waveform or asymmetric waveform to either minimize or enhance irreversible effects on cells in the target tissue. Combined reversible and irreversible electroporation includes inserting one or more therapeutic electrodes into a target tissue, introducing an electroporation compound into the target tissue, selecting a pulse waveform that is either 1) asymmetric bipolar that has positive and negative pulses with different durations, or 2) symmetric bipolar that has positive and negative pulses with the same duration, and delivering to the target tissue a series of electrical pulses having the selected pulse waveform.

Abstract: A motor drive system including a motor including two three-phase winding sets, wherein each three-phase winding set is connected a respective three-phase three-level inverter.

Abstract: Provided are embodiments including a system for balancing DC bus capacitors for converters. The system can include a first 3-phase system, and a second 3-phase system, wherein the first 3-phase system and the second 3-phase system are operably connected. The system can also include one or more DC capacitors coupled to the first 3-phase system and the second 3-phase system, and a controller, wherein the controller is configured to control switching of the first 3-phase system and the second 3-phase system so that an output of second 3-phase system is delayed 60 degrees from an output of the first 3-phase system. Also, embodiments are provided for a method for balancing DC bus capacitors.

Abstract: A motor drive system including a motor including two three-phase winding sets, wherein each three-phase winding set is connected a respective three-phase three-level inverter.

Abstract: A radiation therapy treatment method includes providing a patient model, dosimetric constraints, delivery motion constraints, and delivery coordinate space of a radiation delivery device, where the delivery coordinate space is represented as a mesh with vertices connected by edges, where the vertices correspond to directions of a beam eye view (BEV) of the radiation delivery device. BEV region connectivity manifolds are constructed from the patient model, the dosimetric constraints, the delivery coordinate space, and existing beam trajectories, wherein each of the BEV region connectivity manifolds represents connections between contiguous 2D target regions. Beam trajectories are selected based on region connectedness information in the BEV region connectivity manifolds, the dosimetric constraints, the delivery motion constraints, and the existing beam trajectories. Radiation is delivered using the radiation delivery device in accordance with the selected beam trajectories.

Abstract: A method of operating an elevator system for a learn run sequence including the steps of moving, using a linear propulsion system, an elevator car through a lane of an elevator shaft at a selected velocity; detecting, using a sensor system, the location of the elevator car when it moves through the lane; controlling, using a control system, the elevator car, the control system being in operable communication with the elevator car, the linear propulsion system, and the sensor system; and determining, using the control system, a location of each of the car state sensors relative to each other within the lane in response to at least one of a travel time of the elevator car, a velocity of the elevator car, a position of the elevator car, and a height of the elevator car.

Abstract: A radiation therapy treatment method includes providing a patient model, dosimetric constraints, delivery motion constraints, and delivery coordinate space of a radiation delivery device, where the delivery coordinate space is represented as a mesh with vertices connected by edges, where the vertices correspond to directions of a beam eye view (BEV) of the radiation delivery device. BEV region connectivity manifolds are constructed from the patient model, the dosimetric constraints, the delivery coordinate space, and existing beam trajectories, wherein each of the BEV region connectivity manifolds represents connections between contiguous 2D target regions. Beam trajectories are selected based on region connectedness information in the BEV region connectivity manifolds, the dosimetric constraints, the delivery motion constraints, and the existing beam trajectories. Radiation is delivered using the radiation delivery device in accordance with the selected beam trajectories.

Abstract: The present disclosure describes a Mtu ?I-CM intein variant containing one or more mutations or a biologically active fragment thereof, and a method for producing and purifying a molecule of interest using the intein variant. Further described are isolated fusion proteins comprising the intein variant and a tag and a molecule of interest. Also described are expression systems for expressing the intein variant as well as polypeptide screening methods employing the intein variant.

Abstract: A treatment planning prediction method to predict a Dose-Volume Histogram (DVH) or Dose Distribution (DD) for patient data using a machine-learning computer framework is provided with the key inclusion of a Planning Target Volume (PTV) only treatment plan in the framework. A dosimetric parameter is used as an additional parameter to the framework and which is obtained from a prediction of the PTV-only treatment plan. The method outputs a Dose-Volume Histogram and/or a Dose Distribution for the patient including the prediction of the PTV-only treatment plan. The method alleviates the complicated process of quantifying anatomical features and harnesses directly the inherent correlation between the PTV-only plan and the clinical plan in the dose domain. The method provides a more robust and efficient solution to the important DVHs prediction problem in treatment planning and plan quality assurance.

Abstract: A ratio of reversible electroporation and irreversible electroporation may be controlled by selecting a symmetric waveform or asymmetric waveform to either minimize or enhance irreversible effects on cells in the target tissue. Combined reversible and irreversible electroporation includes inserting one or more therapeutic electrodes into a target tissue, introducing an electroporation compound into the target tissue, selecting a pulse waveform that is either 1) asymmetric bipolar that has positive and negative pulses with different durations, or 2) symmetric bipolar that has positive and negative pulses with the same duration, and delivering to the target tissue a series of electrical pulses having the selected pulse waveform.

Abstract: A ratio of reversible electroporation and irreversible electroporation may be controlled by selecting a symmetric waveform or asymmetric waveform to either minimize or enhance irreversible effects on cells in the target tissue. Combined reversible and irreversible electroporation includes inserting one or more therapeutic electrodes into a target tissue, introducing an electroporation compound into the target tissue, selecting a pulse waveform that is either 1) asymmetric bipolar that has positive and negative pulses with different durations, or 2) symmetric bipolar that has positive and negative pulses with the same duration, and delivering to the target tissue a series of electrical pulses having the selected pulse waveform.

Abstract: A radiation therapy treatment method includes providing a patient model, dosimetric constraints, delivery motion constraints, and delivery coordinate space of a radiation delivery device, where the delivery coordinate space is represented as a mesh with vertices connected by edges, where the vertices correspond to directions of a beam eye view (BEV) of the radiation delivery device. BEV region connectivity manifolds are constructed from the patient model, the dosimetric constraints, the delivery coordinate space, and existing beam trajectories, wherein each of the BEV region connectivity manifolds represents connections between contiguous 2D target regions. Beam trajectories are selected based on region connectedness information in the BEV region connectivity manifolds, the dosimetric constraints, the delivery motion constraints, and the existing beam trajectories. Radiation is delivered using the radiation delivery device in accordance with the selected beam trajectories.

Abstract: The present invention discloses amphiphilic nonsteroid anti-inflammatory platinum nanoparticles, preparation methods therefor and applications thereof. The amphiphilic nonsteroid anti-inflammatory platinum nanoparticle includes an amphiphilic complex formed by coordinating a nonsteroid anti-inflammatory drug and a platinum antitumor drug. Compared with other platinum drugs, the amphiphilic nonsteroid anti-inflammatory platinum prepared according to the present invention can self-assemble into a nanoparticle in an aqueous solution without the addition of an additive or a surfactant. The amphiphilic platinum complex can achieve targeted accumulation of tumor tissues by means of the enhanced permeability and retention effect of the tumor tissues, thereby reducing the side effects of platinum drugs.

Abstract: A manufacturing method of an OLED anode and display device are provided, which the former method comprises the steps: forming an anode-film layer, a material is an ITO, on a substrate; forming a photoresist-film layer on the anode-film layer; patterning the photoresist-film layer to acquire a photoresist-mask pattern, which comprises: an area of photoresist full-retention, photoresist half-retention, and a photoresist full-removal, wherein the photoresist area of half-retention is located between the full-retention and the full-removal; etching the anode film layer to acquire an anode pattern; removing the photoresist half-retention area; perform a plasma treatment to a portion of the anode pattern outside the photoresist full-retention area by adopting a first gas, comprising at least one of O2, N2O, CF4, Ar; removing the photoresist-mask pattern.

Abstract: The disclosure provides an OLED display device and a process for manufacturing the same, wherein the OLED display device includes a substrate, a first electrode, an organic functional layer, a second electrode, a polymer dispersed liquid crystal (PDLC) layer, and an upper electrode stacked in sequence, wherein the first electrode is an opaque electrode, and the second electrode is a semi-transparent electrode, and a micro-cavity structure consists of the first electrode, the organic functional layer, and the second electrode. The disclosure implements anti-peeping function and ensures the privacy of the display contents of the OLED display device while doing no harm to the organic functional layer. The disclosure also ensures that the display contents of the OLED display device can be dearly seen in a variety of angle.