Abstract: The present invention relates to a method for determining size of biomolecules separated in a medium by an electric field using marker molecules of known size, comprising —(101) detecting a plurality of bands and forming a detected marker sequence and a detected unknown sequence based on a separation criterion, —(102) determining band properties for each detected band, —(103) comparing the band properties of the detected bands of the detected marker sequence with known band properties for a plurality of marker molecules forming a known marker sequence and assigning a score to each comparison, said score being based on at least one of relative distance, relative intensity, expected distance and expected intensity between bands, —(104) selecting the comparison with the highest score and associating all or a subset of the detected bands of the detected marker sequence with said plurality of marker molecules of the known marker sequence in accordance with said comparison to determine size of the all or a subset o

Abstract: The present invention relates to a method for identification of specific target proteins in a protein sample following a detection procedure, such as a Western blotting procedure, wherein the membrane is probed with at least two primary antibodies directed against the same and/or different epitopes of the same target protein, and wherein specific binding to the target protein in a sample is differentiated from unspecific binding to the target protein by comparing the resulting sample patterns, such as bands or spot patterns, with each other. In a further step signals from the true target proteins are enhanced while signals resulting from unspecific binding are diminished.

Abstract: The present invention relates to a method for determining size of biomolecules separated in a medium by an electric field using marker molecules of known size, comprising—(101) detecting a plurality of bands and forming a detected marker sequence and a detected unknown sequence based on a separation criterion, —(102) determining band properties for each detected band, —(103) comparing the band properties of the detected bands of the detected marker sequence with known band properties for a plurality of marker molecules forming a known marker sequence and assigning a score to each comparison, said score being based on at least one of relative distance, relative intensity, expected distance and expected intensity between bands, —(104) selecting the comparison with the highest score and associating all or a subset of the detected bands of the detected marker sequence with said plurality of marker molecules of the known marker sequence in accordance with said comparison to determine size of the all or a subset of

Abstract: A role-based access control method and/or system permits end users to securely pair their mobile devices via a pairing apparatus with one or more instruments to, for example, remotely monitor operations of the instruments. In an embodiment, the process includes a pairing apparatus receiving a pairing request from an instrument including a unique access code, and receiving a pairing request from an end user mobile device that includes an end user mobile device identifier and an access code. If the unique access code matches the end user's access code, then the end user mobile device identifier is added to a security group and a successful pairing message is transmitted to at least one of the instrument and the end user mobile device.

Abstract: A method of determining the relative component proportions of at least one each of: a buffer; an acid or a base; a solvent; and optionally a salt, for providing a liquid mixture of pre-defined pH and ionic strength, wherein the relative component proportions are determined using the equation of Debye-Hückel, wherein the ion size parameter a in the Debye-Hückel equation is determined as the weighted mean ion size of all species contributing to the ionic strength of the liquid mixture, and wherein the ionic strength of each species is used as weighting parameter. The present method is also applicable in a method of providing a liquid mixture. Further there is provided a buffer preparation device.

Abstract: Electrophoresis gel cassette comprising a first and a second face wall member and one or more side wall members defining a gel compartment for a gel member with a first and second face, wherein at least a section of each one of the first and second face wall member is removable to expose a section of both the first and second face of the gel member essentially corresponding to the separation zone while the gel member is preserved in the cassette.

Abstract: A role-based access control method and/or system permits end users to securely pair their mobile devices via a pairing apparatus with one or more instruments to, for example, remotely monitor operations of the instruments. In an embodiment, the process includes a pairing apparatus receiving a pairing request from an instrument including a unique access code, and receiving a pairing request from an end user mobile device that includes an end user mobile device identifier and an access code. If the unique access code matches the end user's access code, then the end user mobile device identifier is added to a security group and a successful pairing message is transmitted to at least one of the instrument and the end user mobile device.

Abstract: Electrophoresis gel cassette comprising a first and a second face wall member and one or more side wall members defining a gel compartment for a gel member with a first and second face, wherein at least a section of each one of the first and second face wall member is removable to expose a section of both the first and second face of the gel member essentially corresponding to the separation zone while the gel member is preserved in the cassette.

Abstract: Electrophoresis gel unit comprising a flat gel member with an upper and a lower face and a sample separation zone, wherein the gel member is attached to a rigid support arranged to preserve the shape of and to facilitate handling of the gel member, wherein the rigid support is formed to allow access to a section of both the upper and lower face of the gel member essentially corresponding to the separation zone.

Abstract: Electrophoresis gel cassette comprising a first and a second face wall member and one or more side wall members, defining a gel compartment for a gel member with a first and second face, wherein the first face wall member has high gel adhesion compared to the second face wall member, whereby a gel member molded in the cassette will stay attached to the high gel adhesion face wall member when the cassette is opened, and wherein the first face wall member is provided with at least one removable section to expose a section of the first face of the gel member, the removable section of the first face wall member having lower gel adhesion compared to the non-removable part of the first face wall member.

Abstract: The present invention relates to a method for identification of specific target proteins in a protein sample following a detection procedure, such as a Western blotting procedure, wherein the membrane is probed with at least two primary antibodies directed against the same and/or different epitopes of the same target protein, and wherein specific binding to the target protein in a sample is differentiated from unspecific binding to the target protein by comparing the resulting sample patterns, such as bands or spot patterns, with each other. In a further step signals from the true target proteins are enhanced while signals resulting from unspecific binding are diminished.

Abstract: A method of determining the relative component proportions of at least one each of: a buffer; an acid or a base; a solvent; and optionally a salt, for providing a liquid mixture of pre-defined pH and ionic strength, wherein the relative component proportions are determined using the equation of Debye-Hückel, wherein the ion size parameter a in the Debye-Hückel equation is determined as the weighted mean ion size of all species contributing to the ionic strength of the liquid mixture, and wherein the ionic strength of each species is used as weighting parameter. The present method is also applicable in a method of providing a liquid mixture. Further there is provided a buffer preparation device.

Abstract: A method is provided for comparing multiple samples of cell extract containing a plurality of components. The method comprises the steps of preparing at least two samples of cell extract from at least two groups of cells and of exposing each of said sample of said cell extract to a different one of a set of matched markers, e.g. luminescent markers, to bind the marker to the cell extract to label the cell extract, each marker within said set of markers being capable of binding to the cell extract and can be individually detected from all other markers within said set. The samples are then mixed to form a mixture and said mixture is electrophoresed to separate the components within the cell extract. At least two electronic images of the electrophoresed mixture are obtained (I) by detection of the individual markers, each image being represented by detection of a marker different from the others.

Abstract: A method is provided for comparing multiple samples of cell extract containing a plurality of components. The method comprises the steps of preparing at least two samples of cell extract from at least two groups of cells and of exposing each of said sample of said cell extract to a different one of a set of matched markers, e.g. luminescent markers, to bind the marker to the cell extract to label the cell extract, each marker within said set of markers being capable of binding to the cell extract and can be individually detected from all other markers within said set. The samples are then mixed to form a mixture and said mixture is electrophoresed to separate the components within the cell extract. At least two electronic images of the electrophoresed mixture are obtained (I) by detection of the individual markers, each image being represented by detection of a marker different from the others.

Abstract: The method and measurement system according to the invention performs combined Chromatography and Mass Spectrometry analysis and comprises the steps of: performing an C/MS analysis 300; generating at least one first elution profile 305, wherein one dimension is an elution time of the chromatography, and one dimension is mass to charge ratio (m/z), and at least one dimension a signal intensity, and the signal from each biomolecule species is dispersed forming a plurality of signal peaks associated with each biomolecule species in the elution profile; and reassembling 310 the dispersed signal originating from one biomolecule species in the elution profile. The reassembling comprises an automated annotation adapted to reassemble signal variations in the elution profile that originate from the same biomolecule species and generating a biomolecule map. The automated annotating is simultaneously based on both the elution time-dimension and the m/z-dimension.

Abstract: A method is provided for comparing multiple samples of cell extract containing a plurality of components. The method comprises the steps of preparing at least two samples of cell extract from at least two groups of cells and of exposing each of said sample of said cell extract to a different one of a set of matched markers, e.g. luminescent markers, to bind the marker to the cell extract to label the cell extract, each marker within said set of markers being capable of binding to the cell extract and can be individually detected from all other markers within said set. The samples are then mixed to form a mixture and said mixture is electrophoresed to separate the components within the cell extract. At least two electronic images of the electrophoresed mixture are obtained (I) by detection of the individual markers, each image being represented by detection of a marker different from the others.

Abstract: A method and a system for identifying mutations within nucleic acid sequences. Using raw data signals from conventional nucleic acid sequencing equipment, a method to create input signals that enables a properly trained neural network to output a mutation/no mutation signal is provided. Further, an instrument system to perform the method is provided.