Abstract: An apparatus or method for forming a sterile connection. The apparatus includes at least two sterile tubes each disposed within a flange. Each flange has an external face that completely covers the mouth of the tube. Each flange is designed to be displaced when force is applied to the tube to move the tubes toward one another such that the external face of each flange is displaced radially or axially outwards away from the mouth of the tube. When the external faces are displaced, the external face of each flange opens and tubes connect and form a sterile connection therebetween.

Abstract: A disposable device for the sterile transfer of fluids, such as liquids or gases, includes a body, a bore formed through at least a portion of the interior of the body, and a linearly moveable plunger contained within the bore. The body is formed from a rotating section and a stationary section. Partial rotation of the rotating section around a portion of the stationary section and the plunger drives the plunger linearly within the bore, opening and closing the device. The plunger includes at least a first and a second opening, and a fluid channel in the interior of the plunger connecting the first and second openings forming a fluid pathway to downstream components when the device is open. A termination component at one end of the plunger connects to a downstream component. A flange at one end of the body attaches to an upstream component.

Abstract: A device in a valve includes a valve housing with at least a first and a second fluid port. A closure element including a sealing portion and a diaphragm is arranged in the valve housing. The sealing portion is movable between an open position and a closed position. The closure element and valve housing form a flow passage which communicates with the fluid ports when the sealing portion leaves the closed position. A second sealing portion is arranged in contact with a support portion of the valve housing. An abutment element is arranged in contact with the second sealing portion. The abutment element transmits a force via the second sealing portion toward the support portion to provide a seal. The force is at least partly exerted by a spring element.

Abstract: A device in a valve (1) comprises a valve housing (2) with at least a first (3) and a second (4) fluid port. A closure element (5) is arranged in the valve housing (2), said closure element (5) having a sealing portion (15) and comprising a diaphragm (30). The sealing portion (15) is movable along an axis of the closure element (5) by said diaphragm (30) between an open position and a closed position of at least one of the fluid ports of the valve housing. The closure element (5) together with the valve housing (2) forms a flow passage (11) in the valve housing (2) which communicates with said fluid ports when the sealing portion (15) leaves said closed position. A second sealing portion (14) of the closure element, which is an enclosing portion spaced from said axis, is arranged in contact with a support portion (25) of the valve housing (2).

Abstract: A disposable device for the sterile transfer of fluids, such as liquids or gases, includes a body, a bore formed through at least a portion of the interior of the body, and a linearly moveable plunger contained within the bore. The body is formed from a rotating section and a stationary section. Partial rotation of the rotating section around a portion of the stationary section and the plunger drives the plunger linearly within the bore, opening and closing the device. The plunger includes at least a first and a second opening, and a fluid channel in the interior of the plunger connecting the first and second openings forming a fluid pathway to downstream components when the device is open. A termination component at one end of the plunger connects to a downstream component. A flange at one end of the body attaches to an upstream component.

Abstract: A device in a valve (1) comprises a valve housing (2) with at least a first (3) and a second (4) fluid port. A closure element (5) is arranged in the valve housing (2), said closure element (5) having a sealing portion (15) and comprising a diaphragm (30). The sealing portion (15) is movable along an axis of the closure element (5) by said diaphragm (30) between an open position and a closed position of at least one of the fluid ports of the valve housing. The closure element (5) together with the valve housing (2) forms a flow passage (11) in the valve housing (2) which communicates with said fluid ports when the sealing portion (15) leaves said closed position. A second sealing portion (14) of the closure element, which is an enclosing portion spaced from said axis, is arranged in contact with a support portion (25) of the valve housing (2).

Abstract: A device in a valve (1) includes a valve housing (2) with at least a first (3) and a second (4) fluid port. A closure element (5) including a sealing portion (15) and diaphragm (30) is arranged in the valve housing (2). The sealing portion (15) is movable between an open position and a closed position. The closure element (5) and valve housing (2) form a flow passage (11) which communicates with the fluid ports when the sealing portion (15) leaves the closed position. A second sealing portion (14) is arranged in contact with a support portion (25) of the valve housing (2). An abutment element (16) is arranged in contact with the second sealing portion (14). The abutment element (16) transmits a force via the second sealing portion (14) toward the support portion (25) to provide a seal. The force is at least partly exerted by a spring element.

Abstract: A disposable device for the sterile transfer of fluids, such as liquids or gases, includes a body, a bore formed through at least a portion of the interior of the body, and a linearly moveable plunger contained within the bore. The body is formed from a rotating section and a stationary section. Partial rotation of the rotating section around a portion of the stationary section and the plunger drives the plunger linearly within the bore, opening and closing the device. The plunger includes at least a first and a second opening, and a fluid channel in the interior of the plunger connecting the first and second openings forming a fluid pathway to downstream components when the device is open. A termination component at one end of the plunger connects to a downstream component. A flange at one end of the body attaches to an upstream component.

Abstract: A device for cutting/shearing in a process vessel (1) product clusters and/or materials (3) into smaller particles and dispersing them in a liquid product bulk (4) or for mixing in the process vessel liquid products with each other that are difficult to mix. The device has an electric motor (13) arranged out-side the process vessel and, driven by the same by magneto drive, a processing unit (12) positioned inside the process vessel. The processing unit comprises a stationary inner part (14) and, rotatable about this, an outer part (15), the inner and outer parts having the shape of substantially concentric rings (16, 17) arranged with a close fit to each other and having a plurality of through slotshaped shearing recesses (18) opposing each other.

Abstract: A method and a device are provided for contamination-free and/or sterile sealing between two interconnectable connecting elements having opposing openings. Interconnection allows transfer of a fluid between the openings. Sealing elements are arranged on the connecting elements around the openings, and protective films are provided, covering the sealing elements and the openings and adapted to be removed in the final interconnection. The sealing elements are each provided with at least one recess which extends wholly or partly around the associated opening and receives a gas. In use the sealing elements are moved into engagement with each other, interleaved with the protective films, to reduce the volume of the recesses and, thus, increase the pressure of the gas therein. During removal of the protective films, the gas flows out of the recesses to the environment to prevent penetration of contamination into the openings.

Abstract: A device in a valve (1) comprises a valve housing (2) with at least a first (3) and a second (4) fluid port. A closure element (5) is arranged in the valve housing (2), said closure element (5) having a sealing portion (15) and comprising a diaphragm (30). The sealing portion (15) is movable along an axis of the closure element (5) by said diaphragm (30) between an open position and a closed position of at least one of the fluid ports of the valve housing. The closure element (5) together with the valve housing (2) forms a flow passage (11) in the valve housing (2) which communicates with said fluid ports when the sealing portion (15) leaves said closed position. A second sealing portion (14) of the closure element, which is an enclosing portion spaced from said axis, is arranged in contact with a support portion (25) of the valve housing (2).

Abstract: A device in a valve (1) includes a valve housing (2) with at least a first (3) and a second (4) fluid port. A closure element (5) including a sealing portion (15) and diaphragm (30) is arranged in the valve housing (2). The sealing portion (15) is movable between an open position and a closed position. The closure element (5) and valve housing (2) form a flow passage (11) which communicates with the fluid ports when the sealing portion (15) leaves the closed position. A second sealing portion (14) is arranged in contact with a support portion (25) of the valve housing (2). An abutment element (16) is arranged in contact with the second sealing portion (14). The abutment element (16) transmits a force via the second sealing portion (14) toward the support portion (25) to provide a seal. The force is at least partly exerted by a spring element.

Abstract: A method and a device are provided for interconnecting, sealed against contamination, the ends of tubes by two cooperating connecting components, each having an inlet and an outlet for connection to each other. The connecting components each have a connecting plane, into which the outlets open, each covered by a protective component, and which are movable into engagement with each other with the outlets facing each other. A locking element, which is slidably arranged on one connecting component, is, in a controlled manner and without interruption of the sliding movement, movable onto the other connecting component to a distinct end position. The protective components are removable by means of the locking element when this is moved, and the outlets are sealingly pressable against each other. The locking element is prevented from moving until a predetermined force is applied in the moving direction.

Abstract: A device for cutting/shearing in a process vessel (1) product clusters and/or materials (3) into smaller particles and dispersing them in a liquid product bulk (4) or for mixing in the process vessel liquid products with each other that are difficult to mix. The device has an electric motor (13) arranged out-side the process vessel and, driven by the same by magneto drive, a processing unit (12) positioned inside the process vessel. The processing unit comprises a stationary inner part (14) and, rotatable about this, an outer part (15), the inner and outer parts having the shape of substantially concentric rings (16, 17) arranged with a close fit to each other and having a plurality of through slotshaped shearing recesses (18) opposing each other.

Abstract: A device for cutting/shearing in a process vessel (1) product clusters and/or materials (3) into smaller particles and dispersing them in a liquid product bulk (4) or for mixing in the process vessel liquid products with each other that are difficult to mix. The device has an electric motor (13) arranged out-side the process vessel and, driven by the same by magneto drive, a processing unit (12) positioned inside the process vessel. The processing unit comprises a stationary inner part (14) and, rotatable about this, an outer part (15), the inner and outer parts having the shape of substantially concentric rings (16, 17) arranged with a close fit to each other and having a plurality of through slotshaped shearing recesses (18) opposing each other.

Abstract: A syringe for a fluid comprises a cylinder, a piston portion arranged in the cylinder and slidable on its inside, and an operating means connected to the piston portion for sliding thereof. The operating means projects from a first end of the cylinder and the cylinder has at a second end an inlet and outlet part for said fluid. Moreover a sealing means is connected in a contamination-free manner to the cylinder in the area of the first end thereof and extends into the cylinder to isolate, sealed against contamination, the inside of the cylinder from the environment.

Abstract: A disposable device for the sterile transfer of fluids, such as liquids or gases, includes a body, a bore formed through at least a portion of the interior of the body, and a linearly moveable plunger contained within the bore. The body is formed from a rotating section and a stationary section. Partial rotation of the rotating section around a portion of the stationary section and the plunger drives the plunger linearly within the bore, opening and closing the device. The plunger includes at least a first and a second opening, and a fluid channel in the interior of the plunger connecting the first and second openings forming a fluid pathway to downstream components when the device is open. A termination component at one end of the plunger connects to a downstream component. A flange at one end of the body attaches to an upstream component.

Abstract: A method and a device are provided for contamination-free and/or sterile sealing between two interconnectable connecting means having opposing openings. Interconnection allows transfer of a fluid between the openings. Sealing elements are arranged on the connecting means around the openings, and protective films are provided, covering the sealing elements and the openings and adapted to be removed in the final interconnection. The sealing elements are each provided with at least one recess which extends wholly or partly around the associated opening and receives a gas. In use the sealing elements are moved into engagement with each other, interleaved with the protective films, to reduce the volume of the recesses and, thus, increase the pressure of the gas therein. During removal of the protective films, the gas flows out of the recesses to the environment to prevent penetration of contamination into the openings.

Abstract: A method and a device are provided for interconnecting, sealed against contamination, the ends of tubes by two cooperating connecting means, each having an inlet and an outlet for connection to each other. The connecting means each have a connecting plane, into which the outlets open, each covered by a protective means, and which are movable into engagement with each other with the outlets facing each other. A locking element, which is slidably arranged on one connecting means, is, in a controlled manner and without interruption of the sliding movement, movable onto the other connecting means to a distinct end position. The protective means are removable by means of the locking element when this is moved, and the outlets are sealingly pressable against each other. The locking element is prevented from moving until a predetermined force is applied in the moving direction.

Abstract: A device in a valve (1) comprises a valve housing (2) with at least a first (3) and a second (4) fluid port. A closure element (5) is arranged in the valve housing (2), said closure element (5) having a sealing portion (15) and comprising a diaphragm (30). The sealing portion (15) is movable along an axis of the closure element (5) by said diaphragm (30) between an open position and a closed position of at least one of the fluid ports of the valve housing. The closure element (5) together with the valve housing (2) forms a flow passage (11) in the valve housing (2) which communicates with said fluid ports when the sealing portion (15) leaves said closed position. A second sealing portion (14) of the closure element, which is an enclosing portion spaced from said axis, is arranged in contact with a support portion (25) of the valve housing (2).