Patents by Inventor Leo E. Otterbein

Leo E. Otterbein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERAPEUTIC CARBON MONOXIDE FORMULATIONS
    Publication number: 20230398141
    Abstract: A pharmaceutical composition is described that includes a pharmaceutical carrier comprising gas pockets containing carbon monoxide gas, wherein the pharmaceutical carrier is a foam, a solid, or a hydrogel. Methods of using the pharmaceutical composition to treat an inflammatory disease or condition, and methods of making the pharmaceutical composition, are also described.
    Type: Application
    Filed: September 8, 2021
    Publication date: December 14, 2023
    Inventors: Carlo Giovanni Traverso, James D. Byme, Hannah Boyce, Leo E. Otterbein, David J. Gallo
  • METHODS OF TREATING DNA DAMAGE
    Publication number: 20190008895
    Abstract: The present invention relates to methods and compositions of treating patients suffering from, or at risk for, DNA damage and to increase life span, i.e., prevent or slow the aging process in all species. The treatment includes administering to the patient a pharmaceutical composition that includes carbon monoxide.
    Type: Application
    Filed: May 3, 2018
    Publication date: January 10, 2019
    Inventor: Leo E. Otterbein
  • Methods of treating DNA damage
    Patent number: 9987302
    Abstract: The present invention relates to methods and compositions of treating patients suffering from, or at risk for, DNA damage and to increase life span, i.e., prevent or slow the aging process in all species. The treatment includes administering to the patient a pharmaceutical composition that includes carbon monoxide.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: June 5, 2018
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventor: Leo E. Otterbein
  • Methods of treating hepatitis
    Patent number: 9522163
    Abstract: The present invention relates to a method of treating hepatitis in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
    Type: Grant
    Filed: December 2, 2013
    Date of Patent: December 20, 2016
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Yale University
    Inventors: Leo E. Otterbein, Augustine M. K. Choi, Brian Scott Zuckerbraun
  • METHODS OF TREATING DNA DAMAGE
    Publication number: 20140243581
    Abstract: The present invention relates to methods and compositions of treating patients suffering from, or at risk for, DNA damage and to increase life span, i.e., prevent or slow the aging process in all species. The treatment includes administering to the patient a pharmaceutical composition that includes carbon monoxide.
    Type: Application
    Filed: August 8, 2012
    Publication date: August 28, 2014
    Applicant: BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
    Inventor: Leo E. Otterbein
  • METHODS OF TREATING HEPATITIS
    Publication number: 20140141103
    Abstract: The present invention relates to a method of treating hepatitis in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
    Type: Application
    Filed: December 2, 2013
    Publication date: May 22, 2014
    Inventors: Leo E. Otterbein, Augustine M. K. Choi, Brian Scott Zuckerbraun
  • Method of Treating Hepatitis
    Publication number: 20120276220
    Abstract: The present invention relates to a method of treating hepatitis in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
    Type: Application
    Filed: July 9, 2012
    Publication date: November 1, 2012
    Applicants: Yale University, University of Pittsburgh of the Commonwealth System of Higher Education
    Inventors: Leo E. Otterbein, Augustine M. K. Choi, Brian Zuckerbraun
  • Methods of treating necrotizing enterocolitis
    Patent number: 7981448
    Abstract: The present invention relates to a method of treating necrotizing enterocolitis in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
    Type: Grant
    Filed: April 15, 2003
    Date of Patent: July 19, 2011
    Assignee: University of Pittsburgh
    Inventors: Leo E. Otterbein, Brian Zuckerbraun
  • Methods of treating vascular disease
    Patent number: 7691416
    Abstract: The present invention relates to a method of treating patients suffering from, or at risk for, intimal hyperplasia and/or arteriosclerosis. The treatment includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
    Type: Grant
    Filed: March 18, 2008
    Date of Patent: April 6, 2010
    Assignees: Beth Israel Deaconess Medical Center, Inc., University of Pittsburgh of the Commonwealth System of Higher Education
    Inventors: Leo E. Otterbein, Augustine M. Choi, Fritz H. Bach, Brian Zuckerbraun
  • Methods of treating ileus
    Patent number: 7687079
    Abstract: The present invention relates to a method of treating ileus in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: March 30, 2010
    Assignees: University of Pittsburgh of the Commonwealth System of Higher Education Yale University, Yale University
    Inventors: Leo E. Otterbein, Augustine M. K. Choi, Beverley A. Moore, Anthony J. Bauer
  • Carbon monoxide as a biomarker and therapeutic agent
    Patent number: 7678390
    Abstract: The present invention relates to the use of carbon monoxide (CO) as a biomarker and therapeutic agent of heart, lung, liver, spleen, brain, skin and kidney diseases and other conditions and disease states including, for example, asthma, emphysema, bronchitis, adult respiratory distress syndrome, sepsis, cystic fibrosis, pneumonia, interstitial lung diseases, idiopathic pulmonary diseases, other lung diseases including primary pulmonary hypertension, secondary pulmonary hypertension, cancers, including lung, larynx and throat cancer, arthritis, wound healing, Parkinson's disease, Alzheimer's disease, peripheral vascular disease and pulmonary vascular thrombotic diseases such as pulmonary embolism. CO may be used to provide anti-inflammatory relief in patients suffering from oxidative stress and other conditions especially including sepsis and septic shock.
    Type: Grant
    Filed: January 15, 2002
    Date of Patent: March 16, 2010
    Assignees: Yale University, John Hopkins University
    Inventors: Augustine M. K. Choi, Leo E. Otterbein
  • PHARMACEUTICAL USE OF NITRIC OXIDE, HEME OXYGENASE-1 AND PRODUCTS OF HEME DEGRADATION
    Publication number: 20080171021
    Abstract: The present invention relates to the treatment of disorders using nitric oxide (NO), heme oxygenase-1 (HO-1) and heme degradation products such as carbon monoxide (CO), biliverdin, bilirubin and iron.
    Type: Application
    Filed: October 31, 2007
    Publication date: July 17, 2008
    Applicants: Beth Israel Deaconess Medical Center, Inc., University of Pittsburgh of the Commonwealth System of Higher Education
    Inventors: Fritz H. Bach, Leo E. Otterbein
  • METHODS OF TREATING VASCULAR DISEASE
    Publication number: 20080167609
    Abstract: The present invention relates to a method of treating patients suffering from, or at risk for, intimal hyperplasia and/or arteriosclerosis. The treatment includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
    Type: Application
    Filed: March 18, 2008
    Publication date: July 10, 2008
    Inventors: Leo E. Otterbein, Augustine M. K. Choi, Fritz H. Bach, Brian Zuckerbraun
  • Methods of treating vascular disease
    Patent number: 7364757
    Abstract: The present invention relates to a method of treating patients suffering from, or at risk for, intimal hyperplasia and/or arteriosclerosis. The treatment includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
    Type: Grant
    Filed: February 13, 2003
    Date of Patent: April 29, 2008
    Assignees: University of Pittsburgh of the Commonwealth System of Higher Education, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Leo E. Otterbein, Augustine M. K. Choi, Fritz H. Bach, Brian Zuckerbraun
  • Carbon monoxide improves outcomes in tissue and organ transplants and suppresses apoptosis
    Patent number: 7238469
    Abstract: The present invention features methods for transplanting organs, tissues and individual cells. Also featured are methods for maintaining cells in vitro and for enhancing survival and/or function of cells following transplantation. The methods include the administration of carbon monoxide in an amount sufficient to enhance cell survival and/or function.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: July 3, 2007
    Assignees: Beth Israel Deaconess Medical Center, Inc., Yale University
    Inventors: Fritz H. Bach, Leo E. Otterbein, Miguel P. Soares, Jeanne Gose
  • Methods of treating angiogenesis, tumor growth, and metastasis
    Publication number: 20040258772
    Abstract: The present invention relates to a method of treating cancer or unwanted angiogenesis in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
    Type: Application
    Filed: June 5, 2003
    Publication date: December 23, 2004
    Inventors: Leo E. Otterbein, Augustine M. K. Choi
  • Treatment for hemorrhagic shock
    Publication number: 20040228930
    Abstract: The present invention relates to methods and compositions of treating patients suffering from, or at risk for, hemorrhagic shock. The treatment includes administering to the patient a pharmaceutical composition that includes carbon monoxide.
    Type: Application
    Filed: September 30, 2003
    Publication date: November 18, 2004
    Inventors: Timothy R. Billiar, Augustine M.K. Choi, Carol A. McCloskey, Leo E. Otterbein, Brian Zuckerbraun
  • Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation
    Publication number: 20040131703
    Abstract: The present invention relates to the treatment of disorders using nitric oxide (NO), heme oxygenase-1 (HO-1) and heme degradation products such as carbon monoxide (CO), biliverdin, bilirubin and iron.
    Type: Application
    Filed: June 20, 2003
    Publication date: July 8, 2004
    Inventors: Fritz H. Bach, Leo E. Otterbein
  • Methods of treating hepatitis
    Publication number: 20040052866
    Abstract: The present invention relates to a method of treating hepatitis in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
    Type: Application
    Filed: May 16, 2003
    Publication date: March 18, 2004
    Inventors: Leo E. Otterbein, Augustine M. K. Choi, Brian Zuckerbraun
  • Methods of treating necrotizing enterocolitis
    Publication number: 20040005367
    Abstract: The present invention relates to a method of treating necrotizing enterocolitis in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
    Type: Application
    Filed: April 15, 2003
    Publication date: January 8, 2004
    Inventors: Leo E. Otterbein, Brian Zuckerbraun