Abstract: A high-performance electrochemically active sodium molten salt catholyte enables a dramatic reduction in molten sodium battery operating temperature from near 300° C. to less than 120° C. As an example, stable electrochemical cycling was demonstrated in a high voltage (3.65 V) sodium battery comprising a sodium iodide-gallium chloride (NaI—GaCl3) molten salt catholyte for over 8 months at 110° C. The combination of high voltage, stable cycling behavior, and practical current densities supported by a molten catholyte enables a new generation of transformative high performance, low temperature molten sodium batteries.

Abstract: Described herein are systems and methods that receive as input a DNA or RNA sequence, extract features, and apply layers of processing units to compute one ore more condition-specific cell variables, corresponding to cellular quantities measured under different conditions. The system may be applied to a sequence containing a genetic variant, and also to a corresponding reference sequence to determine how much the condition-specific cell variables change because of the variant. The change in the condition-specific cell variables are used to compute a score for how deleterious a variant is, to classify a variant's level of deleteriousness, to prioritize variants for subsequent processing, and to compare a test variant to variants of known deleteriousness.

Abstract: Described herein are systems and methods that receive as input a DNA or RNA sequence, extract features, and apply layers of processing units to compute one ore more condition-specific cell variables, corresponding to cellular quantities measured under different conditions. The system may be applied to a sequence containing a genetic variant, and also to a corresponding reference sequence to determine how much the condition-specific cell variables change because of the variant. The change in the condition-specific cell variables are used to compute a score for how deleterious a variant is, to classify a variant's level of deleteriousness, to prioritize variants for subsequent processing, and to compare a test variant to variants of known deleteriousness.

Abstract: Described herein are systems and methods that receive as input a DNA or RNA sequence, extract features, and apply layers of processing units to compute one ore more condition-specific cell variables, corresponding to cellular quantities measured under different conditions. The system may be applied to a sequence containing a genetic variant, and also to a corresponding reference sequence to determine how much the condition-specific cell variables change because of the variant. The change in the condition-specific cell variables are used to compute a score for how deleterious a variant is, to classify a variant's level of deleteriousness, to prioritize variants for subsequent processing, and to compare a test variant to variants of known deleteriousness.

Abstract: Described herein are systems and methods that receive as input a DNA or RNA sequence, extract features, and apply layers of processing units to compute one ore more condition-specific cell variables, corresponding to cellular quantities measured under different conditions. The system may be applied to a sequence containing a genetic variant, and also to a corresponding reference sequence to determine how much the condition-specific cell variables change because of the variant. The change in the condition-specific cell variables are used to compute a score for how deleterious a variant is, to classify a variant's level of deleteriousness, to prioritize variants for subsequent processing, and to compare a test variant to variants of known deleteriousness.

Abstract: Described herein are systems and methods that receive as input a DNA or RNA sequence, extract features, and apply layers of processing units to compute one ore more condition-specific cell variables, corresponding to cellular quantities measured under different conditions. The system may be applied to a sequence containing a genetic variant, and also to a corresponding reference sequence to determine how much the condition-specific cell variables change because of the variant. The change in the condition-specific cell variables are used to compute a score for how deleterious a variant is, to classify a variant's level of deleteriousness, to prioritize variants for subsequent processing, and to compare a test variant to variants of known deleteriousness.

Abstract: A system and method that facilitate modeling unobserved speech dynamics based upon a hidden dynamic speech model in the form of segmental switching state space model that employs model parameters including those describing the unobserved speech dynamics and those describing the relationship between the unobserved speech dynamic vector and the observed acoustic feature vector is provided. The model parameters are modified based, at least in part, upon, a variational learning technique. In accordance with an aspect of the present invention, novel and powerful variational expectation maximization (EM) algorithm(s) for the segmental switching state space models used in speech applications, which are capable of capturing key internal (or hidden) dynamics of natural speech production, are provided. For example, modification of model parameters can be based upon an approximate mixture of Gaussian (MOG) posterior and/or based upon an approximate hidden Markov model (HMM) posterior using a variational technique.

Abstract: A system and method that facilitate modeling unobserved speech dynamics based upon a hidden dynamic speech model in the form of segmental switching state space model that employs model parameters including those describing the unobserved speech dynamics and those describing the relationship between the unobserved speech dynamic vector and the observed acoustic feature vector is provided. The model parameters are modified based, at least in part, upon, a variational learning technique. In accordance with an aspect of the present invention, novel and powerful variational expectation maximization (EM) algorithm(s) for the segmental switching state space models used in speech applications, which are capable of capturing key internal (or hidden) dynamics of natural speech production, are provided. For example, modification of model parameters can be based upon an approximate mixture of Gaussian (MOG) posterior and/or based upon an approximate hidden Markov model (HMM) posterior using a variational technique.