Patents by Inventor Leo J. Romanczyk
Leo J. Romanczyk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20030176620Abstract: A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphenol monomer. The protected polyphenol may be a protected polyphenol monomer or a protected polyphenol oligomer having 2-17 monomeric units. Advantageously, polyphenol monomeric units forming the polyphenol oligomers may be the same or different flavanoid compounds.Type: ApplicationFiled: January 31, 2003Publication date: September 18, 2003Applicant: Mars IncorporatedInventors: Leo J. Romanczyk, Alan P. Kozikowski, Werner Tueckmantel, Marc E. Lippman
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Patent number: 6599553Abstract: A dry drink mix which is rich in cocoa polyphenols such as catechin, epicatechin, and cocoa procyanidins contains a cocoa polyphenol rich cocoa powder, an alkalized cocoa powder, and a sweetener. The dry mix contains other conventional ingredients such as vanillin an emulsifier. A chocolate flavored drink can be prepared from the dry drink mix by adding milk, for example a low fat milk. The cocoa polyphenol rich cocoa powder is prepared from non-roasted cocoa beans or blends thereof having a fermentation factor of 275 less, i.e., slaty and/or purple cocoa beans. The alkalized cocoa powder is prepared from roasted cocoa beans.Type: GrantFiled: November 5, 2001Date of Patent: July 29, 2003Assignee: Mars IncorporatedInventors: Kirk S. Kealey, Rodney M. Snyder, Leo J. Romanczyk, Jr., Hans M. Geyer, Mary E. Myers, Eric J. Whitacre, John F. Hammerstone, Jr., Harold H. Schmitz
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Publication number: 20030114691Abstract: Processes are disclosed for the production of linear and branched procyanidin oligomers having “n” procyanidin monomeric units where n is 2 to 18. The processes include coupling protected, activated monomers with an unprotected monomer to produce a partially protected (4→8) dimer. The dimer is optionally blocked, coupled with an activated protected monomer to produce a partially protected, optionally blocked trimer, and deprotected. The steps can be repeated to produce higher oligomers. Processes are also provided for producing (8→8), (8→6), and (6→6) dimers and doubly branched oligomers. Crystalline 8-bromo tetra-O-benzyl (−)-epicatechin is produced under certain conditions.Type: ApplicationFiled: August 6, 2002Publication date: June 19, 2003Applicant: Mars IncorporatedInventors: Leo J. Romanczyk, Amit Basak, Craig A. Townsend
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Publication number: 20030113290Abstract: Disclosed and claimed are cocoa extracts, compounds, combinations thereof and compositions containing the same, such as polyphenols or procyanidins, methods for preparing such extracts, compounds and compositions, as well as uses for them, especially a polymeric compound of the formula An, wherein A is a monomer of the formula: 1Type: ApplicationFiled: April 22, 2002Publication date: June 19, 2003Applicant: MARS IncorporatedInventors: Leo J. Romanczyk,, Harold H. Schmitz
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Publication number: 20030104075Abstract: Foods and pharmaceuticals which contain cocoa and/or nut procyanidin(s) in combination with L-arginine are effective to induce a physiological increase in nitric oxide production in a mammal having ingested the product. A preferred food product is a confection, particularly a dark or milk chocolate containing nuts. The procyanidins may be natural or synthetic and may be provided by food ingredients such as chocolate liquor and/or cocoa solids prepared from underfermented beans and nut skins. The L-arginine may be natural or synthetic and may be provided by food ingredients such as nut meats, nut pastes, and/or nut flours, seeds, seed pastes, and/or seed flours, or gelatin. The beneficial health effects may include, for example, reduced blood pressure, resistance to cardiovascular disease, and anticancer activity.Type: ApplicationFiled: June 19, 2002Publication date: June 5, 2003Applicant: Mars IncorporatedInventors: Kati A. Chevaux, Harold H. Schmitz, Leo J. Romanczyk
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Publication number: 20030100775Abstract: Oligomeric procyanidins containing 4&agr;-linked epicatechin units are rare in nature and have hitherto not been accessible through stereoselective synthesis. Provided herein is the preparation of the prototypical dimer, epicatechin-4&agr;,8-epicatechin, by reaction of the protected 4-ketones with aryllithium reagents derived by halogen/metal exchange from the aryl bromides. Removal of the 4-hydroxyl group from the resulting tertiary benzylic alcohols is effected by tri-n-butyltin hydride and trifluoroacetic acid in a completely stereoselective manner, resulting in hydride delivery exclusively from the &bgr; face.Type: ApplicationFiled: August 8, 2002Publication date: May 29, 2003Applicant: Mars IncorporatedInventors: Alan P. Kozikowski, Leo J. Romanczyk, Werner Tuckmantel
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Publication number: 20030100601Abstract: A method for reducing postprandial oxidative stress and associated pathologies by the dietary intake of cocoa procyanidins, such as epicatechin is disclosed.Type: ApplicationFiled: November 27, 2002Publication date: May 29, 2003Applicant: Mars IncorporatedInventors: Harold H. Schmitz, Leo J. Romanczyk
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Patent number: 6562863Abstract: Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants. Disclosed and claimed are antineoplastic compositions containing cocoa polyphenols or procyanidins and methods for treating patients employing the compositions. Additionally disclosed and claimed is a kit for treating a patient in need of treatment with an antineoplastic agent containing cocoa polyphenols or procyanidins as well as a lyophilized antineoplastic composition containing cocoa polyphenols or procyanidins. Further, disclosed and claimed is the use of the invention in antioxidant, preservative and topiosomerase-inhibiting compositions and methods.Type: GrantFiled: January 24, 2001Date of Patent: May 13, 2003Assignee: Mars IncorporatedInventors: Leo J. Romanczyk, Jr., John F. Hammerstone, Jr., Margaret M. Buck
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Patent number: 6558713Abstract: Cocoa components having enhanced levels of cocoa polyphenols, processes for producing the cocoa components while conserving a significant amount of the cocoa polyphenols, compositions containing the cocoa components or the cocoa polyphenols, and methods of using the cocoa components or the cocoa polyphenols for improving the health of a mammal are described. The cocoa components include partially and fully defatted cocoa solids, cocoa nibs and fractions derived therefrom, cocoa polyphenol extracts, cocoa butter, chocolate liquors, and mixtures thereof. The invention provides processes for extracting fat from cocoa beans and for otherwise processing cocoa beans to yield a cocoa component having conserved concentrations of polyphenols relative to the starting materials.Type: GrantFiled: October 16, 2001Date of Patent: May 6, 2003Assignee: Mars, IncorporatedInventors: Kirk S. Kealey, Rodney M. Snyder, Leo J. Romanczyk, Jr., Hans M. Geyer, Mary E. Myers, Eric J. Whitacre, John F. Hammerstone, Jr., Harold H. Schmitz
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Patent number: 6528664Abstract: A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphenol monomer. The protected polyphenol may be a protected polyphenol monomer or a protected polyphenol oligomer having 2-17 monomeric units. Advantageously, polyphenol monomeric units forming the polyphenol oligomers may be the same or different flavanoid compounds.Type: GrantFiled: December 14, 2001Date of Patent: March 4, 2003Assignee: Mars, IncorporatedInventors: Leo J. Romanczyk, Jr., Alan P. Kozikowski, Werner Tueckmantel, Marc E. Lippman
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Patent number: 6517841Abstract: Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants. Disclosed and claimed are antineoplastic compositions containing cocoa polyphenols or procyanidins and methods for treating patients employing the compositions. Additionally disclosed and claimed is a kit for treating a patient in need of treatment with an antineoplastic agent containing cocoa polyphenols or procyanidins as well as a lyophilized antineoplastic composition containing cocoa polyphenols or procyanidins. Further, disclosed and claimed is the use of the invention in antioxidant, preservative and topiosomerase-inhibiting compositions and methods.Type: GrantFiled: October 11, 2001Date of Patent: February 11, 2003Assignee: Mars IncorporatedInventors: Leo J. Romanczyk, Jr., John F. Hammerstone, Jr., Margaret M. Buck
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Patent number: 6479539Abstract: Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants. Disclosed and claimed are antineoplastic compositions containing cocoa polyphenols or procyanidins-and methods for treating patients employing the compositions. Additionally disclosed and claimed is a kit for treating a patient in need of treatment with an antineoplastic agent containing cocoa polyphenols or procyanidins as well as a lyophilized antineoplastic composition containing cocoa polyphenols or procyanidins. Further, disclosed and claimed is the use of the invention in antioxidant, preservative and topiosomerase-inhibiting compositions and methods.Type: GrantFiled: April 22, 1997Date of Patent: November 12, 2002Assignee: Mars, IncorporatedInventors: Leo J. Romanczyk, Jr., John F. Hammerstone, Jr., Margaret M. Buck
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Patent number: 6476241Abstract: Oligomeric procyanidins containing 4&agr;-linked epicatechin units are rare in nature and have hitherto not been accessible through stereoselective synthesis. Provided herein is the preparation of the prototypical dimer, epicatechin-4&agr;,8-epicatechin, by reaction of the protected 4-ketones with aryllithium reagents derived by halogen/metal exchange from the aryl bromides. Removal of the 4-hydroxyl group from the resulting tertiary benzylic alcohols is effected by tri-n-butyltin hydride and trifluoroacetic acid in a completely stereoselective manner, resulting in hydride delivery exclusively from the &bgr; face.Type: GrantFiled: September 5, 2000Date of Patent: November 5, 2002Assignee: Mars IncorporatedInventors: Alan P. Kozikowski, Leo J. Romanczyk, Jr., Werner Tückmantel
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Patent number: 6469053Abstract: Cocoa extracts which include procyanidin monomers and their oligomers are useful in the modulation of inflammatory pathways, in the maintenance of the vascular health of a mammal and as an antibacterial treatment. The liquid or dry cocoa extracts can be included in foods, food supplements and pharmaceuticals for the inhibition of COX activity, the inhibition of LOX activity, the enhancement of nitric oxide production, the modulation of eicosanoids and endothelin, and the modulation of platelet activity.Type: GrantFiled: February 18, 2000Date of Patent: October 22, 2002Assignee: Mars IncorporatedInventors: Leo J. Romanczyk, Jr., Harold H. Schmitz
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Publication number: 20020132018Abstract: The present invention is directed to a method of processing a fat-containing bean, e.g., cocoa beans, for producing solids comprising active polyphenols and/or fat-containing products, comprising extracting the fat to produce solids and fat-containing products. Additionally, the inventive method also provides cocoa compositions comprising at least one active polyphenol, wherein the concentration of the polyphenol(s) with respect to the nonfat solids is conserved with respect to the concentration of the active polyphenol(s) in the bean from which the compositions are derived.Type: ApplicationFiled: November 8, 2001Publication date: September 19, 2002Applicant: MARS, INCORPORATEDInventors: Kirk S. Kealey, Rodney M. Snyder, Leo J. Romanczyk, John F. Hammerstone, Margaret M. Buck, Giovanni G. Cipolla
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Publication number: 20020128493Abstract: A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphenol monomer. The protected polyphenol may be a protected polyphenol monomer or a protected polyphenol oligomer having 2-17 monomeric units. Advantageously, polyphenol monomeric units forming the polyphenol oligomers may be the same or different flavanoid compounds.Type: ApplicationFiled: December 14, 2001Publication date: September 12, 2002Applicant: Mars, IncorporatedInventors: Leo J. Romanczyk, Alan P. Kozikowski, Werner Tueckmantel, Marc E. Lippman
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Patent number: 6420572Abstract: A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphenol monomer. The protected polyphenol may be a protected polyphenol monomer or a protected polyphenol oligomer having 2-17 monomeric units. Advantageously, polyphenol monomeric units forming the polyphenol oligomers may be the same or different flavanoid compounds.Type: GrantFiled: October 9, 1998Date of Patent: July 16, 2002Assignee: Mars, IncorporatedInventors: Leo J. Romanczyk, Jr., Alan P. Kozikowski, Werner Tueckmantel, Marc E. Lippman
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Publication number: 20020086833Abstract: Polyphenol-containing compositions, for example cocoa procyanidin monomer and/or oligomer-containing compositions, and their use for inhibiting bacterial growth are disclosed. Compositions may be used for human and veterinary animal administration and may be, for example, in a form of a food, a dietary supplement, or a pharmaceutical.Type: ApplicationFiled: February 5, 2001Publication date: July 4, 2002Applicant: Mars, IncorporatedInventors: Leo J. Romanczyk, John F. Hammerstone, Margaret M. Buck, Laurie S. Post, Giovanni G. Cipolla, Craig A. McClelland, Jeff A. Mundt, Harold H. Schmitz
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Publication number: 20020064584Abstract: Cocoa components having enhanced levels of cocoa polyphenols, processes for producing the cocoa components while conserving a significant amount of the cocoa polyphenols, compositions containing the cocoa components or the cocoa polyphenols, and methods of using the cocoa components or the cocoa polyphenols for improving the health of a mammal are described. The cocoa components include partially and fully defatted cocoa solids, cocoa nibs and fractions derived therefrom, cocoa polyphenol extracts, cocoa butter, chocolate liquors, and mixtures thereof. The invention provides processes for extracting fat from cocoa beans and for otherwise processing cocoa beans to yield a cocoa component having conserved concentrations of polyphenols relative to the starting materials.Type: ApplicationFiled: November 5, 2001Publication date: May 30, 2002Applicant: Mars, IncorporatedInventors: Kirk S. Kealey, Rodney M. Snyder, Leo J. Romanczyk, Hans M. Geyer, Mary E. Myers, Eric J. Whitacre, John F. Hammerstone, Harold H. Schmitz
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Publication number: 20020048613Abstract: Cocoa oils containing phytosterols and tocols are prepared by extracting the cocoa hulls from dried unfermented or fermented cocoa beans, micronized cocoa beans, or roasted beans with a solvent such as petroleum ether and then removing the solvent. The cocoa oils are useful in foods, dietary supplements, pharmaceuticals, and cosmetics.Type: ApplicationFiled: April 11, 2001Publication date: April 25, 2002Inventors: Leo J. Romanczyk, Craig McClelland