Abstract: An ergonomic power supply for a computer system includes a printed circuit board assembly configured to convert a mains electricity input to voltage-regulated, direct-current (DC) outputs. The printed circuit board assembly defines a mains input and has one or more DC output connectors. An enclosure houses a fan and the printed circuit board assembly. The enclosure has a rear panel, a front panel positioned opposite the rear panel relative to the printed circuit board assembly. A side panel is positioned between the front and rear panel. The mains connector extends through an aperture defined by the rear panel of the enclosure. The one or more DC output connectors extend through the side panel. Such an arrangement provides significantly easier access to the power supply outputs compared to conventional power supplies. Associated computer systems also are described.