Patents by Inventor Leon Ekchian
Leon Ekchian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220331581Abstract: The present disclosure relates to methods, devices and systems used for the treatment of neurological disorders via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, minimally invasive methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infratrochlear, auriculotermporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal, infraorbital, and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein. Systems and devices configured for therapeutic stimulation of the branches of the trigeminal nerves, such as the superficial trigeminal nerve, and their methods of application are also described.Type: ApplicationFiled: June 30, 2022Publication date: October 20, 2022Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEUROSIGMA, INC.Inventors: Christopher DeGiorgio, Ian A. Cook, Leon Ekchian
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Publication number: 20190269922Abstract: The present disclosure relates to methods, devices and systems used for the treatment of neurological disorders via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, minimally invasive methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infratrochlear, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal, infraorbital, and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein. Systems and devices configured for therapeutic stimulation of the branches of the trigeminal nerves, such as the superficial trigeminal nerve, and their methods of application are also described.Type: ApplicationFiled: March 4, 2019Publication date: September 5, 2019Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEUROSIGMA, INC.Inventors: Christopher DeGiorgio, Ian A. Cook, Leon Ekchian
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Patent number: 10195435Abstract: The present disclosure relates to methods, devices, and systems used for the treatment of mood, anxiety, cognitive, and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, minimally invasive systems, devices and methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: GrantFiled: November 10, 2016Date of Patent: February 5, 2019Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEUROSIGMA, INC.Inventors: Christopher M. Degiorgio, Ian A. Cook, Leon Ekchian
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Patent number: 10035013Abstract: An implantable subcutaneous electrode system is disclosed. The implantable subcutaneous electrode system may include an electrode body with electrical contacts disposed thereon or integrally formed therein. The electrode body also may include an insulation region defined between the electrical contacts and an aperture defined in the electrode body for receiving an anchoring device. A minimally invasive delivery device and methods for delivery of an implantable electrode system is also provided. The methods may include steps of introducing a needle comprising a cannula and a stylet through a patient's skin, removing the stylet while leaving the cannula in place, introducing an electrode applicator through the cannula, the electrode applicator comprising a hollow driver which receives the electrode assembly, and anchoring the electrode assembly to a bone by driving the hollow driver such that a self-tapping screw within the electrode assembly screws into the bone.Type: GrantFiled: April 5, 2013Date of Patent: July 31, 2018Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEUROSIGMA, INC.Inventors: Antonio A. F. Desalles, Alessandra Gorgulho, Christopher M. DeGiorgio, Ian A. Cook, Colin Kealey, Leon Ekchian, Patrick Miller
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Patent number: 10016601Abstract: A system for trigeminal nerve stimulation includes a pulse generator, which includes a user control configured to receive a user adjustment and a microcontroller configured to receive electric stimulation parameters and operate the pulse generator to produce electrical pulses according to the electric stimulation parameters during a treatment session. A method for nerve stimulation includes receiving, by a pulse generator, electric stimulation parameters, and producing, by the pulse generator, electrical pulses according to electric stimulation parameters during a treatment session. The electric stimulation parameters include at least one user-set parameter, which includes a current amplitude that is responsive to the user adjustment of the user control, and at least one physician-set parameter, which includes an upper bound and a lower bound for the current amplitude.Type: GrantFiled: May 20, 2016Date of Patent: July 10, 2018Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEUROSIGMA, INC.Inventors: Ian A. Cook, Christopher M. DeGiorgio, Leon Ekchian, Patrick Miller, Colin Kealey
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Publication number: 20170354821Abstract: Cutaneous and subcutaneous TNS embodiments are disclosed for addressing autonomic nervous system imbalances. A cutaneous electrode assembly is applied to a patient's forehead, and a current is pulsed through the electrode assembly to stimulate the supraorbital and supratrochlear nerves on the patient to increase activity for the patient's parasympathetic nervous system. Pulsing the current increases the power spectral density for the patient's heart rate variability in a 0.1 to 0.15 Hz frequency band.Type: ApplicationFiled: August 14, 2017Publication date: December 14, 2017Inventors: Colin Kealey, Leon Ekchian
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Publication number: 20170348521Abstract: The present disclosure relates to methods, devices and systems used for the treatment of medical disorders via stimulation of the superficial elements of the trigeminal nerve. More specifically, minimally invasive systems, devices and methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: ApplicationFiled: June 15, 2017Publication date: December 7, 2017Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEUROSIGMA, INC., UNITED STATES GOVERNMENT DEPARTMENT OF VETERANS AFFAIRSInventors: Ian A. Cook, Christopher M. DeGiorgio, Leon Ekchian, Patrick Miller, Antonio De Salles
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Patent number: 9731127Abstract: Cutaneous and subcutaneous TNS embodiments are disclosed for addressing autonomic nervous system imbalances. A cutaneous electrode assembly is applied to a patient's forehead, and a current is pulsed through the electrode assembly to stimulate the supraorbital and supratrochlear nerves on the patient to increase activity for the patient's parasympathetic nervous system. Pulsing the current increases the power spectral density for the patient's heart rate variability in a 0.1 to 0.15 Hz frequency band.Type: GrantFiled: April 24, 2014Date of Patent: August 15, 2017Assignee: NeuroSigma, Inc.Inventors: Colin Kealey, Leon Ekchian
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Publication number: 20170056660Abstract: The present disclosure relates to methods, devices, and systems used for the treatment of mood, anxiety, cognitive, and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, minimally invasive systems, devices and methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: ApplicationFiled: November 10, 2016Publication date: March 2, 2017Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEUROSIGMA, INC.Inventors: Christopher M. Degiorgio, Ian A. Cook, Leon Ekchian
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Patent number: 9511223Abstract: The present disclosure relates to methods, devices, and systems used for the treatment of mood, anxiety, cognitive, and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, minimally invasive systems, devices and methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: GrantFiled: February 11, 2015Date of Patent: December 6, 2016Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEUROSIGMA, INC.Inventors: Christopher M. DeGiorgio, Ian A. Cook, Leon Ekchian
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Publication number: 20160339242Abstract: A system for trigeminal nerve stimulation includes a pulse generator, which includes a user control configured to receive a user adjustment and a microcontroller configured to receive electric stimulation parameters and operate the pulse generator to produce electrical pulses according to the electric stimulation parameters during a treatment session. A method for nerve stimulation includes receiving, by a pulse generator, electric stimulation parameters, and producing, by the pulse generator, electrical pulses according to electric stimulation parameters during a treatment session. The electric stimulation parameters include at least one user-set parameter, which includes a current amplitude that is responsive to the user adjustment of the user control, and at least one physician-set parameter, which includes an upper bound and a lower bound for the current amplitude.Type: ApplicationFiled: May 20, 2016Publication date: November 24, 2016Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEUROSIGMA, INC.Inventors: Ian A. Cook, Christopher M. DeGiorgio, Leon Ekchian, Patrick Miller, Colin Kealey
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Publication number: 20160317814Abstract: The present disclosure relates to methods, devices and systems used for the treatment of neurological disorders via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, minimally invasive methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infratrochlear, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal, infraorbital, and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein. Systems and devices configured for therapeutic stimulation of the branches of the trigeminal nerves, such as the superficial trigeminal nerve, and their methods of application are also described.Type: ApplicationFiled: May 2, 2016Publication date: November 3, 2016Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEUROSIGMA, INC.Inventors: Christopher DeGiorgio, Ian A. Cook, Leon Ekchian
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Publication number: 20160184585Abstract: Cutaneous and subcutaneous TNS embodiments are disclosed for addressing autonomic nervous system imbalances. A cutaneous electrode assembly is applied to a patient's forehead, and a current is pulsed through the electrode assembly to stimulate the supraorbital and supratrochlear nerves on the patient to increase activity for the patient's parasympathetic nervous system. Pulsing the current increases the power spectral density for the patient's heart rate variability in a 0.1 to 0.15 Hz frequency band.Type: ApplicationFiled: April 24, 2014Publication date: June 30, 2016Inventors: Colin Kealey, Leon Ekchian
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Patent number: 9364674Abstract: A system for trigeminal nerve stimulation includes a storage medium, a pulse generator in communication with the storage medium, a power source coupled to the pulse generator, and at least one electrode communicatively coupled to the pulse generator. The pulse generator includes a microcontroller which executes instructions from the storage medium and the microcontroller is configured to perform at least one of the following operations: produce electrical pulses having defined characteristics, record a log of use and anomalous events, restrict use to a specified individual, interface with electrodes, provide a signal to the specified individual indicating operational conditions and trouble conditions, and provide a signal to the specified individual indicating an end of a treatment period.Type: GrantFiled: November 30, 2011Date of Patent: June 14, 2016Inventors: Ian A. Cook, Christopher M. DeGiorgio, Leon Ekchian, Patrick Miller, Colin Kealey
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Publication number: 20150151128Abstract: The present disclosure relates to methods, devices, and systems used for the treatment of mood, anxiety, cognitive, and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, minimally invasive systems, devices and methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: ApplicationFiled: February 11, 2015Publication date: June 4, 2015Inventors: Christopher M. DEGIORGIO, Ian A. COOK, Leon EKCHIAN
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Publication number: 20150119898Abstract: An implantable subcutaneous electrode system is disclosed. A minimally invasive delivery device and methods for delivery of an implantable electrode system is also provided.Type: ApplicationFiled: April 5, 2013Publication date: April 30, 2015Inventors: Antonio A.F. Desalles, Alessandra Gorgulho, Christopher M. Degiorgio, Ian A. Cook, Colin Kealey, Leon Ekchian, Patrick Miller
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Patent number: 8958880Abstract: The present disclosure relates to methods, devices, and systems used for the treatment of mood, anxiety, cognitive, and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, minimally invasive systems, devices and methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: GrantFiled: October 5, 2010Date of Patent: February 17, 2015Assignees: The Regents of the University of California, Neurosigma, Inc.Inventors: Christopher DeGiorgio, Ian A. Cook, Leon Ekchian
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Publication number: 20140142669Abstract: The present disclosure relates to methods, devices and systems used for the treatment of medical disorders via stimulation of the superficial elements of the trigeminal nerve. More specifically, minimally invasive systems, devices and methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: ApplicationFiled: December 14, 2011Publication date: May 22, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Ian A. Cook, Christopher M. DeGiorgio, Leon Ekchian, Patrick Miller, Antonio Desalles
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Publication number: 20140135886Abstract: The present disclosure relates to methods, devices and systems used for the treatment of medical disorders via stimulation of the superficial elements of the trigeminal nerve. More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: ApplicationFiled: December 14, 2011Publication date: May 15, 2014Applicant: UNITED STATES GOVERNMENT DEPARTMENT OF VETERANS AFFAIRSInventors: Ian A. Cook, Christopher M. Degiorgio, Leon Ekchian, Patrick Miller, Antonio Desalles, Alejandro Covalin
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Publication number: 20140081353Abstract: Disclosed herein is a system for trigeminal nerve stimulation. In one embodiment, the system includes a storage medium, a pulse generator in communication with the storage medium, a power source coupled to the pulse generator, and at least one electrode communicatively coupled to the pulse generator. The pulse generator includes a microcontroller which executes instructions from the storage medium and the microcontroller is configured to perform at least one of the following operations: produce electrical pulses having defined characteristics, record a log of use and anomalous events, restrict use to a specified individual, interface with electrodes, provide a signal to the specified individual indicating operational conditions and trouble conditions, and provide a signal to the specified individual indicating an end of a treatment period.Type: ApplicationFiled: November 30, 2011Publication date: March 20, 2014Applicants: NEUROSIGMA, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Ian A. Cook, Christopher M. DeGiorgio, Leon Ekchian, Patrick Miller, Colin Kealey