Patents by Inventor Leon Matthieu Johannes Knippels

Leon Matthieu Johannes Knippels has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for inducing oral tolerance via administration of beta-lactoglobulin derived peptides in combination with probiotic
    Patent number: 11389492
    Abstract: The invention pertains to the use of a probiotic and a beta-lactoglobulin-derived peptide in the manufacture of a product for use in inducing oral tolerance, and/or treatment, prevention or reducing the risk of allergy in a subject, in particular cow's milk protein allergy.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: July 19, 2022
    Assignee: N.V. NUTRICIA
    Inventors: Leon Matthieu Johannes Knippels, Johan Garssen
  • Composition comprising vitamin A and non digestible oligosaccharides
    Publication number: 20220218804
    Abstract: The present invention relates to a combination of Vitamin A and non-digestible oligosaccharides for use in treating and/or preventing allergy.
    Type: Application
    Filed: May 18, 2020
    Publication date: July 14, 2022
    Applicant: N.V. Nutricia
    Inventors: Linette Eustachia Maria Willemsen, Johan Garssen, Leon Matthieu Johannes Knippels
  • Formula with a specific beta-lactoglobulin peptide
    Publication number: 20210227869
    Abstract: A formula comprising a whey protein hydrolysate comprising specific beta-lactoglobulin derived peptides and probiotics for inducing oral immune tolerance against milk protein, preventing or treating of oral immune intolerance against milk protein, and/or reducing the risk of developing oral immune intolerance against milk protein.
    Type: Application
    Filed: April 18, 2019
    Publication date: July 29, 2021
    Applicant: N.V. Nutricia
    Inventors: Joost Willem Gouw, Laura Antoinette Petronella Maria Meulenbroek, Juandy Jo, Leon Matthieu Johannes Knippels, Johan Garssen
  • Formula with specific beta-lactoglobulin peptides
    Publication number: 20210227868
    Abstract: A formula comprising a whey protein hydrolysate comprising specific beta-lactoglobulin derived peptides and probiotics for inducing oral immune tolerance against milk protein, preventing or treating of oral immune intolerance against milk protein, and/or reducing the risk of developing oral immune intolerance against milk protein.
    Type: Application
    Filed: April 18, 2019
    Publication date: July 29, 2021
    Applicant: N.V. Nutricia
    Inventors: Joost Willem Gouw, Laura Antoinette Petronella Maria Meulenbroek, Juandy Jo, Leon Matthieu Johannes Knippels, Johan Garssen
  • Immune system stimulating nutrition
    Patent number: 10124016
    Abstract: Disclosed is a nutritional composition comprising a combination of non-digestible oligosaccharides and a product obtained by incubating an aqueous substrate by bifidobacteria and optionally a product obtained by incubating an aqueous substrate by S. thermophilus. Said combination synergistically improves the immune system by stimulating the Th1 response, and/or decreasing the Th2 response, improving the vaccination response, improving the resistance against infections and/or decreasing allergy.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: November 13, 2018
    Assignee: N.V. NUTRICIA
    Inventors: Belinda Potappel-Van 'T Land, Leon Matthieu Johannes Knippels, Alma Jildou Nauta, Johan Garssen
  • METHOD FOR INDUCING ORAL TOLERANCE VIA ADMINISTRATION OF BETA-LACTOGLOBULIN DERIVED PEPTIDES IN COMBINATION WITH PROBIOTIC
    Publication number: 20180110811
    Abstract: The invention pertains to the use of a probiotic and a beta-lactoglobulin-derived peptide in the manufacture of a product for use in inducing oral tolerance, and/or treatment, prevention or reducing the risk of allergy in a subject, in particular cow's milk protein allergy.
    Type: Application
    Filed: March 17, 2016
    Publication date: April 26, 2018
    Applicant: N.V. Nutricia
    Inventors: Leon Matthieu Johannes KNIPPELS, Johan GARSSEN
  • IMMUNE SYSTEM STIMULATING NUTRITION
    Publication number: 20170296563
    Abstract: Disclosed is a nutritional composition comprising a combination of non-digestible oligosaccharides and a product obtained by incubating an aqueous substrate by bifidobacteria and optionally a product obtained by incubating an aqueous substrate by S. thermophilus. Said combination synergistically improves the immune system by stimulating the Th1 response, and/or decreasing the Th2 response, improving the vaccination response, improving the resistance against infections and/or decreasing allergy.
    Type: Application
    Filed: January 13, 2017
    Publication date: October 19, 2017
    Applicant: N.V. Nutricia
    Inventors: Belinda POTAPPEL-VAN 'T LAND, Leon Matthieu Johannes KNIPPELS, Alma Jildou NAUTA, Johan GARSSEN
  • Bifidobacterium for dust mite allergy
    Patent number: 9498523
    Abstract: A composition comprising Bifidobacterium breve for use in improving lung function in human subjects suffering from dust mite allergy.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: November 22, 2016
    Assignee: N.V. NUTRICIA
    Inventors: Jan Knol, Leon Matthieu Johannes Knippels, Dominique Anne Marie Goossens
  • Bifidobacterium for dust mite allergy
    Publication number: 20150297703
    Abstract: A composition comprising Bifidobacterium breve for use in improving lung function in human subjects suffering from dust mite allergy.
    Type: Application
    Filed: June 30, 2015
    Publication date: October 22, 2015
    Inventors: Jan KNOL, Leon Matthieu Johannes KNIPPELS, Dominique Anne Marie GOOSSENS
  • for dust mite allergy
    Patent number: 9119414
    Abstract: A composition comprising Bifidobacterium breve for use in improving lung function in human subjects suffering from dust mite allergy.
    Type: Grant
    Filed: December 8, 2008
    Date of Patent: September 1, 2015
    Assignee: N.V. NUTRICIA
    Inventors: Jan Knol, Leon Matthieu Johannes Knippels, Dominique Anne Marie Goossens
  • MATERNAL SUPPLEMENT TO ENHANCE IMMUNE SYSTEM OF AN INFANT
    Publication number: 20150080334
    Abstract: There is provided compositions and methods for enhancing an immune system and/or preventing an immune system related disorder in a mammalian subject, the composition comprising a non-digestible oligosaccharide which is to be administered to a female who is breast-feeding the mammalian subject.
    Type: Application
    Filed: February 10, 2012
    Publication date: March 19, 2015
    Applicant: N.V. NUTRICIA
    Inventors: Johan Garssen, Astrid Hogenkamp, Elisabeth Catharina Adriana Maria Van Esch, Leon Matthieu Johannes Knippels
  • IMMUNE SYSTEM STIMULATING NUTRITION
    Publication number: 20110182934
    Abstract: Disclosed is a nutritional composition comprising a combination of non-digestible oligosaccharides and a product obtained by incubating an aqueous substrate by bifidobacteria and optionally a product obtained by incubating an aqueous substrate by S. thermophilus. Said combination synergistically improves the immune system by stimulating the Th1 response, and/or decreasing the Th2 response, improving the vaccination response, improving the resistance against infections and/or decreasing allergy.
    Type: Application
    Filed: June 12, 2009
    Publication date: July 28, 2011
    Inventors: Belinda Potappel-van 'T Land, Leon Matthieu Johannes Knippels, Alma Jildou Nauta, Johan Garssen
  • Bifidobacterium for dust mite allergy
    Publication number: 20110014156
    Abstract: A composition comprising Bifidobacterium breve for use in improving lung function in human subjects suffering from dust mite allergy.
    Type: Application
    Filed: December 8, 2008
    Publication date: January 20, 2011
    Inventors: Jan Knol, Leon Matthieu Johannes Knippels, Dominique Anne Marie Goossens