Patents by Inventor Leonard Edwin Post

Leonard Edwin Post has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) FOR USE IN TREATMENT OF DISEASES ASSOCIATED WITH A PTEN DEFICIENCY
    Publication number: 20150209363
    Abstract: A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions associated with a PTEN deficiency that are ameliorated by the inhibition of PARP activity.
    Type: Application
    Filed: March 27, 2015
    Publication date: July 30, 2015
    Inventors: Daniel Chu, Bing Wang, Ying Feng, Yuqiao Shen, Leonard Edwin Post
  • Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) for use in treatment of diseases associated with a PTEN deficiency
    Patent number: 9018201
    Abstract: A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions associated with a PTEN deficiency that are ameliorated by the inhibition of PARP activity.
    Type: Grant
    Filed: August 21, 2013
    Date of Patent: April 28, 2015
    Assignee: Biomarin Pharmaceuticial Inc.
    Inventors: Daniel Chu, Bing Wang, Ying Feng, Yuqiao Shen, Leonard Edwin Post
  • DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) FOR USE IN TREATMENT OF DISEASES ASSOCIATED WITH A PTEN DEFICIENCY
    Publication number: 20140066429
    Abstract: A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions associated with a PTEN deficiency that are ameliorated by the inhibition of PARP activity.
    Type: Application
    Filed: August 21, 2013
    Publication date: March 6, 2014
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Daniel Chu, Bing Wang, Ying Feng, Yuqiao Shen, Leonard Edwin Post
  • Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) for use in treatment of diseases associated with a PTEN deficiency
    Patent number: 8541403
    Abstract: A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions associated with a PTEN deficiency that are ameliorated by the inhibition of PARP activity.
    Type: Grant
    Filed: February 3, 2011
    Date of Patent: September 24, 2013
    Assignee: BioMarin Pharmaceutical Inc.
    Inventors: Daniel Chu, Bing Wang, Ying Feng, Yuqiao Shen, Leonard Edwin Post
  • DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) FOR USE IN TREATMENT OF DISEASES ASSOCIATED WITH A PTEN DEFICIENCY
    Publication number: 20110190288
    Abstract: A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions associated with a PTEN deficiency that are ameliorated by the inhibition of PARP activity.
    Type: Application
    Filed: February 3, 2011
    Publication date: August 4, 2011
    Inventors: Daniel Chu, Bing Wang, Ying Feng, Yuqiao Shen, Leonard Edwin Post
  • Pseudorabies virus protein
    Patent number: 6858385
    Abstract: The present invention provides recombinant DNA molecules comprising a sequence encoding a pseudorabies virus (PRV) glycoprotein selected from the group consisting of gI, gp50, and gp63, host cells transformed by the recombinant DNA molecule sequences, the gI, gp50 and gp63 polypeptides. The present invention also provides subunit vaccines for PRV, methods for protecting animals against PRV infection and methods for distinguishing between infected and vaccinated animals.
    Type: Grant
    Filed: December 24, 2002
    Date of Patent: February 22, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: Erik Aivars Petrovskis, Leonard Edwin Post, James G. Timmins
  • Pseudorabies virus protein
    Publication number: 20030219449
    Abstract: The present invention provides recombinant DNA molecules comprising a sequence encoding a pseudorabies virus (PRV) glycoprotein selected from the group consisting of gI, gp50, and gp63, host cells transformed by said recombinant DNA molecule sequences, the gI, gp50 and gp63 polypeptides. The present invention also provides subunit vaccines for PRV, methods for protecting animals against PRV infection and methods for distinguishing between infected and vaccinated animals.
    Type: Application
    Filed: December 24, 2002
    Publication date: November 27, 2003
    Inventors: Erik Aivars Petrovskis, Leonard Edwin Post, James G. Timmins
  • Pseudorabies virus protein
    Patent number: 6521231
    Abstract: The present invention provides recombinant DNA molecules comprising a sequence encoding a pseudorabies virus (PRV) glycoprotein selected from the group consisting of gI, gp50, and gp63, host cells transformed by said recombinant DNA molecule sequences, the gI, gp50 and gp63 polypeptides. The present invention also provides subunit vaccines for PRV, methods for protecting animals against PRV infection and methods for distinguishing between infected and vaccinated animals.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: February 18, 2003
    Assignee: Pharamcia & Upjohn Company
    Inventors: Erik Aivars Petrovskis, Leonard Edwin Post, James G. Timmins
  • Pseudorabies virus protein
    Patent number: 6261563
    Abstract: The present invention provides recombinant DNA molecules comprising a sequence encoding a pseudorabies virus (PRV) glycoprotein selected from the group consisting of gI, gp50 and gp63 host cells transformed by said recombinant DNA molecule sequences, the gI, gp50 and gp63 polypeptides. The present invention also provides subunit vaccines for PRV, methods for protecting animals against PRV infection and methods for distinguishing between infected and vaccinated animals.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 17, 2001
    Assignee: Pharmacia & Upjohn Company
    Inventors: Erik Aivars Petrovskis, Leonard Edwin Post, James G. Timmins
  • Pseudorabies virus protein cross reference to related applications
    Patent number: 6255078
    Abstract: The present invention provides recombinant DNA molecules comprising a sequence encoding a pseudorabies virus (PRV) glycoprotein selected from the group consisting of gI, gp50, and gp63, host cells transformed by said recombinant DNA molecule sequences, the gI, gp50 and gp63 polypeptides. The present invention also provides subunit vaccines for PRV, methods for protecting animals against PRV infection and methods for distinguishing between infected and vaccinated animals.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 3, 2001
    Assignee: Pharmacia & Upjohn Company
    Inventors: Erik Aivars Petrovskis, Leonard Edwin Post, James G. Timmins
  • Pseudorabies virus protein
    Patent number: 6251634
    Abstract: The present invention provides recombinant DNA molecules comprising a sequence encoding a pseudorabies virus (PRV) glycoprotein selected from the group consisting of gI, gp50, and gp63, host cells transformed by said recombinant DNA molecule sequences, the gI, gp50 and gp63 polypeptides. The present invention also provides subunit vaccines for PRV, methods for protecting animals against PRV infection and methods for distinguishing between infected and vaccinated animals.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 26, 2001
    Assignee: Pharmacia & Upjohn Company
    Inventors: Erik Aivars Petrovskis, Leonard Edwin Post, James G. Timmins
  • Pseudorabies virus protein
    Patent number: 6172186
    Abstract: The present invention provides recombinant DNA molecules comprising a sequence encoding a pseudorabies virus (PRV) glycoprotein selected from the group consisting of gI, gp50, and gp63, host cells transformed by said recombinant DNA molecule sequences, the gI, gp50 and gp63 polypeptides. The present invention also provides subunit vaccines for PRV, methods for protecting animals against PRV infection and methods for distinguishing between infected and vaccinated animals.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 9, 2001
    Assignee: Pharmacia & Upjohn Company
    Inventors: Erik Aivars Petrovskis, Leonard Edwin Post, James G. Timmins
  • Feline calicivirus gene
    Patent number: 5718901
    Abstract: The present invention provides recombinant DNA molecules comprising a sequence encoding a feline calicivirus polypeptide, particularly the capsid protein, host cells transformed by recombinant DNA molecule sequences, and the capsid polypeptides. The present invention also provides subunit vaccines and multivalent vaccines for FCV.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 17, 1998
    Assignee: Pharmacia & Upjohn Company
    Inventors: Richard Calvert Wardley, Leonard Edwin Post
  • Feline calicivirus capsid gene and protein
    Patent number: 5716822
    Abstract: The present invention provides recombinant DNA molecules comprising a sequence encoding a feline calicivirus polypeptide, particularly the capsid protein, host cells transformed by said recombinant DNA molecule sequences, and the capsid polypeptides.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 10, 1998
    Assignee: Pharmacia & Upjohn Company
    Inventors: Richard Calvert Wardley, Leonard Edwin Post
  • Pseudorabies virus protein
    Patent number: 5674709
    Abstract: The present invention provides recombinant DNA molecules comprising a sequence encoding a pseudorabies virus (PRV) glycoprotein selected from the group consisting of gI, gp50, and gp63, host cells transformed by said recombinant DNA molecule sequences, the gI, gp50 and gp63 polypeptides. The present invention also provides subunit vaccines for PRY, methods for protecting animals against PRV infection and methods for distinguishing between infected and vaccinated animals.
    Type: Grant
    Filed: June 21, 1994
    Date of Patent: October 7, 1997
    Assignee: Pharmacia & Upjohn Company
    Inventors: Erik Aivars Petrovskis, Leonard Edwin Post, James G. Timmins