Patents by Inventor Leonid Kirnarsky

Leonid Kirnarsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High-affinity response-selective C-terminal analogs of C5a anaphylatoxin
    Patent number: 6465614
    Abstract: High-affinity response-selective C-terminal analogs of C5a anaphylatoxin are provided. Whereas natural C5a has considerable flexibility in the C-terminal region, the analogs of the invention possess a backbone conformation which is constrained at the C-terminus to a &bgr;-turn. The stabilized &bgr;-turn confers a marked increase in potency of the analogs; the particular &bgr;-turn motif further confers the capability to selectively elicit certain biological responses associated with C5a. Exemplary compounds of the invention are decapeptide analogs of the formula: A1-Ser-Phe-Lys-A2-A3-A4-A5-A6-A7, with the constrained &bgr;-turn being localized in the region of A4-A7.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: October 15, 2002
    Assignee: The Board of Regents of the University of Nebraska
    Inventors: Sam D. Sanderson, Simon A. Sherman, Leonid Kirnarsky, Stephen M. Taylor
  • High-affinity response-selective C-terminal analogs of C5a anaphylatoxin
    Patent number: 5942599
    Abstract: High-affinity response-selective C-terminal analogs of C5a anaphylatoxin are provided. Whereas natural C5a has considerable flexibility in the C-terminal region, the analogs of the invention possess a backbone conformation which is constrained at the C-terminus to a .beta.-turn. The stabilized .beta.-turn confers a marked increase in in potency of the analogs; the particular .beta.-turn motif further confers the capability to selectively elicit certain biological responses associated with C5a. Exemplary compounds of the invention are decapeptide analogs of the formula: A1-Ser-Phe-Lys-A2-A3-A4-A5-A6-A7, with the constrained .beta.-turn being localized in the region of A4-A7.
    Type: Grant
    Filed: December 4, 1997
    Date of Patent: August 24, 1999
    Assignees: Board of Regents of the University of Nebraska, The University of Queensland
    Inventors: Sam D. Sanderson, Simon A. Sherman, Leonid Kirnarsky, Stephen M. Taylor
  • High-affinity response-selective C-terminal analogs of C5a anaphylatoxin
    Patent number: 5696230
    Abstract: High-affinity response-selective C-terminal analogs of C5a anaphylatoxin are provided. Whereas natural C5a has considerable flexibility in the C-terminal region, the analogs of the invention possess a backbone conformation which is constrained at the C-terminus to a .beta.-turn. The stabilized .beta.-turn confers a marked increase in in potency of the analogs; the particular .beta.-turn motif further confers the capability to selectively elicit certain biological responses associated with C5a. Exemplary compounds of the invention are decapeptide analogs of the formula: A1-Ser-Phe-Lys-A2-A3-A4-A5-A6-A7, with the constrained .beta.-turn being localized in the region of A4-A7.
    Type: Grant
    Filed: August 31, 1994
    Date of Patent: December 9, 1997
    Assignees: The Board of Regents of the University of Nebraska, The University of Queensland
    Inventors: Sam D. Sanderson, Simon A. Sherman, Leonid Kirnarsky, Stephen M. Taylor