Abstract: A product is disclosed comprising i) a modulator of the Notch signalling pathway; and ii) an autoantigen or bystander antigen, or a polynucleotide coding for an autoantigen or bystander antigen; as a combined preparation for simultaneous, contemporaneous, separate or sequential use for modulation of immune response.

Abstract: A method is provided for reducing an immune response to an allergen or antigenic determinant thereof in a mammal by administering a modulator of the Notch signalling pathway.

Abstract: Provided is a method for modifying IL-4 expression in a cell using a modulator of Notch signalling. Also provided are methods for generating immune modulatory cytokine profiles with increased IL-4 expression and/or increased IL-10 expression and/or reduced IL-5, IL-13 and TNF? expression. In addition, a method for increasing a TH2 immune response and/or decreasing a TH1 immune response in a cell, using a modulator of Notch signalling, is provided. Methods of treatment are also disclosed.

Abstract: A method for modulating the immune system in a mammal is described comprising simultaneously, contemporaneously, separately or sequentially administering: i) an effective amount of an agonist of Notch signalling; and ii) an effective amount of an immunosuppressive agent.

Abstract: A method is disclosed for therapeutic modulation of Notch signalling by administering a construct comprising a multiplicity of bond, linked or immobilised modulators of Notch signalling.

Abstract: An inhibitor of the Notch signalling pathway is provided for use as an immunostimulant, for example as a vaccine adjuvant.

Abstract: A method for detecting modulators of Notch signalling is described. The method includes the step of monitoring Notch signalling in a cell of the immune system in the presence of a candidate modulator.

Abstract: An inhibitor of the Notch signalling pathway is provided for the manufacture of a medicament for use in the treatment of cancer.

Abstract: New uses of modulators of Notch signalling in therapy and corresponding methods of treatment are provided.

Abstract: A portable wall and ceiling texture machine applicator is housed in a relatively small cabinet mounted on relatively large rear wheels for easy pulling up stairs and on swivel front casters for easy steering. A first material delivery system includes a variable speed pump which delivers particulate texture material at a selected flow rate which enables a creative application of texture. A completely separate delivery system delivers pressurized air to a spray head which merges the particulate texture material and pressurized air to spray it onto a wall or ceiling. Separate power cords supply energy for delivering the particulate texture material and pressurized air so that existing 15-amp house supply circuits may be used. The spray head may be on either a pole gun or a hand gun. A check valve on the spray head prevents a back flow of the particulate material when the spray head is turned off.