Patents by Inventor Leslie B. Overman

Leslie B. Overman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for conducting binding reactions on a solid surface within an enclosed chamber
    Patent number: 7247499
    Abstract: The invention provides an apparatus and method for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber. The invention may be used in conducting hybridization reactions, as of biopolymers such as DNA, RNA, oligonucleotides, peptides, polypeptides, proteins, antibodies, and the like. In another aspect, the invention provides an improved method for mixing a thin film of solution, as in a hybridization chamber. The invention further provides a kit for carrying out the methods of the invention.
    Type: Grant
    Filed: January 21, 2005
    Date of Patent: July 24, 2007
    Assignee: Agilent Technologies, Inc.
    Inventors: Carol T. Schembri, Leslie B. Overman, Charles Z. Hotz
  • Arrays comprising background features that provide for a measure of a non-specific binding and methods for using the same
    Patent number: 7122303
    Abstract: Methods for substantially improved detection and analysis in nucleic acid hybridization assays are described. The methods provide the reliable estimation of background signal which derives primarily from nonspecific hybridization. The invention is useful in chemical, biological, medical and diagnostic techniques, as well as for drug discovery.
    Type: Grant
    Filed: September 17, 1999
    Date of Patent: October 17, 2006
    Assignee: Agilent Technologies, Inc.
    Inventors: Glenda C. Delenstarr, Steven M. Lefkowitz, Kevin J. Luebke, Leslie B. Overman, Nicholas M. Sampas, Jeffery R. Sampson, Paul K. Wolber
  • Method for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber
    Patent number: 6911343
    Abstract: The invention provides an apparatus and method for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber. The invention may be used in conducting hybridization reactions, as of biopolymers such as DNA, RNA, oligonucleotides, peptides, polypeptides, proteins, antibodies, and the like. In another aspect, the invention provides an improved method for mixing a thin film of solution, as in a hybridization chamber. The invention further provides a kit for carrying out the methods of the invention.
    Type: Grant
    Filed: July 6, 2001
    Date of Patent: June 28, 2005
    Assignee: Agilent Technologies, Inc.
    Inventors: Carol T. Schembri, Leslie B. Overman, Charles Z. Hotz
  • TECHNIQUES FOR ASSESSING NONSPECIFIC BINDING OF NUCLEIC ACIDS TO SURFACES
    Publication number: 20020051973
    Abstract: Methods for substantially improved detection and analysis in nucleic acid hybridization assays are described. The methods provide the reliable estimation of background signal which derives primarily from nonspecific hybridization. The invention is useful in chemical, biological, medical and diagnostic techniques, as well as for drug discovery.
    Type: Application
    Filed: September 17, 1999
    Publication date: May 2, 2002
    Inventors: GLENDA C. DELENSTARR, STEVEN M. LEFKOWITZ, KEVIN J. LUEBKE, LESLIE B. OVERMAN, NICHOLAS M. SAMPRAS, JEFFERY R. SAMPSON, PAUL K. WOLBER
  • Apparatus and method for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber
    Publication number: 20020001839
    Abstract: The invention provides an apparatus and method for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber. The invention may be used in conducting hybridization reactions, as of biopolymers such as DNA, RNA, oligonucleotides, peptides, polypeptides, proteins, antibodies, and the like. In another aspect, the invention provides an improved method for mixing a thin film of solution, as in a hybridization chamber. The invention further provides a kit for carrying out the methods of the invention.
    Type: Application
    Filed: July 6, 2001
    Publication date: January 3, 2002
    Inventors: Carol T. Schembri, Leslie B. Overman, Charles Z. Hotz
  • Apparatus for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber
    Patent number: 6258593
    Abstract: The invention provides an apparatus and method for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber. The invention may be used in conducting hybridization reactions, as of biopolymers such as DNA, RNA, oligonucleotides, peptides, polypeptides, proteins, antibodies, and the like. In another aspect, the invention provides an improved method for mixing a thin film of solution, as in a hybridization chamber. The invention further provides a kit for carrying out the methods of the invention.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: July 10, 2001
    Assignee: Agilent Technologies Inc.
    Inventors: Carol T. Schembri, Leslie B. Overman, Charles Z. Hotz