Patents by Inventor Leslie G. Humber

Leslie G. Humber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5958445
    Abstract: This invention discloses organoleptically acceptable formulations containing non-solubilized S(+) 1,8-diethyl-1,3,4,9-tetrahydropyrano?3,4-b!indole-1-acetic acid, preferably with an acidic component, also known as S(+)etodolic acid or S(+)etodolac.
    Type: Grant
    Filed: January 14, 1998
    Date of Patent: September 28, 1999
    Assignee: American Home Products Corporation
    Inventors: Leslie G. Humber, Gerald L. Reuter
  • Patent number: 5780046
    Abstract: This invention discloses organoleptically acceptable formulations containing S(+)-2-(p-isobutylphenyl)-propionic acid, also known as S(+) ibuprofen.
    Type: Grant
    Filed: June 10, 1996
    Date of Patent: July 14, 1998
    Assignee: American Home Products Corporation
    Inventors: Leslie G. Humber, Gerald L. Reuter
  • Patent number: 5047552
    Abstract: Disclosed herein are novel benzopyrans having pharmacological activity, to a process for preparing them, to pharmaceutical compositions containing them, and to their use in the treatment of hypertension.
    Type: Grant
    Filed: February 7, 1990
    Date of Patent: September 10, 1991
    Assignee: American Home Products Corporation
    Inventors: Dominick A. Quagliato, Leslie G. Humber
  • Patent number: 4971960
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at positions 5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: February 14, 1989
    Date of Patent: November 20, 1990
    Assignee: American Home Products Corporation
    Inventors: Alan H. Katz, Christopher A. Demerson, Leslie G. Humber
  • Patent number: 4925839
    Abstract: Disclosed herein are novel benzopyrans having pharmacological activity, to a process for preparing them, to pharmaceutical compositions containing them, and to their use in the treatment of hypertension.
    Type: Grant
    Filed: June 24, 1988
    Date of Patent: May 15, 1990
    Assignee: American Home Products Corporation
    Inventors: Dominick A. Quagliato, Leslie G. Humber
  • Patent number: 4898967
    Abstract: Process for the production of substituted 2-oxocyclohexaneacetic acid esters and intermediates used for their production. The substituted 2-oxocyclohexaneacetic acid esters are themselves useful intermediates for the manufacture of substituted 2,3,4,9-tetrahydro-1H-carabazole-1-acetic acid derivatives having useful analgesic and anti-inflammatory activity.
    Type: Grant
    Filed: February 13, 1989
    Date of Patent: February 6, 1990
    Assignee: American Home Products Corp.
    Inventors: Philip F. Hughes, Dominick Mobilio, Leslie G. Humber
  • Patent number: 4861910
    Abstract: Process for the production of substituted 2-oxocyclohexaneacetic acid esters and intermediates used for their production. The substituted 2-oxocyclohexaneacetic acid esters are themselves useful intermediates for the manufacture of substituted 2,34,9-tetrahydro-1H-carbazole-1-acetic acid derivatives having useful analgesic and anti-inflammatory activity.
    Type: Grant
    Filed: December 11, 1987
    Date of Patent: August 29, 1989
    Assignee: American Home Products Corporation
    Inventors: Philip F. Hughes, Dominick Mobilio, Leslie G. Humber
  • Patent number: 4847389
    Abstract: Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives and methods for their preparation and use are disclosed. The compounds are useful analgesic and anti-inflammatory agents.
    Type: Grant
    Filed: June 13, 1988
    Date of Patent: July 11, 1989
    Assignee: American Home Products
    Inventors: Dominick Mobilio, Leslie G. Humber
  • Patent number: 4826994
    Abstract: Production of indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at positions 5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: February 26, 1988
    Date of Patent: May 2, 1989
    Assignee: American Home Products Corporation
    Inventors: Alan H. Katz, Christopher A. Demerson, Leslie G. Humber
  • Patent number: 4782076
    Abstract: Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives and methods of their preparation and use are disclosed. The compounds are useful analgesic and anti-inflammatory agents.
    Type: Grant
    Filed: March 1, 1988
    Date of Patent: November 1, 1988
    Assignee: American Home Products Corporation
    Inventors: Dominick Mobilio, Leslie G. Humber
  • Patent number: 4775690
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at positions 5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: January 13, 1987
    Date of Patent: October 4, 1988
    Assignee: American Home Products Corporation
    Inventors: Alan H. Katz, Christopher A. Demerson, Leslie G. Humber
  • Patent number: 4748266
    Abstract: Process for the production of substituted 2-oxocyclohexaneacetic acid esters and intermediates used for their production. The substituted 2-oxocyclohexaneacetic acid esters are themselves useful intermediates for the manufacture of substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives having useful analgesic and anti-inflammatory activity.
    Type: Grant
    Filed: March 2, 1987
    Date of Patent: May 31, 1988
    Assignee: American Home Products Corporation
    Inventors: Philip F. Hughes, Dominick Mobilio, Leslie G. Humber
  • Patent number: 4748252
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at position 8. The derivatives are useful anti-inflammatory and analgesic agents and methods and chemical intermediates for their preparation are also disclosed.
    Type: Grant
    Filed: January 28, 1987
    Date of Patent: May 31, 1988
    Assignee: American Home Products Corporation
    Inventors: Eckhardt S. Ferdinandi, Dominick Mobilio, Joseph P. Sabatucci, Leslie G. Humber
  • Patent number: 4709048
    Abstract: Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives and methods for their preparation. The compounds are useful analgesic and anti-inflammatory agents.
    Type: Grant
    Filed: March 31, 1987
    Date of Patent: November 24, 1987
    Assignee: American Home Products Corp.
    Inventors: Dominick Mobilio, Christopher A. Demerson, Leslie G. Humber
  • Patent number: 4701533
    Abstract: Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives and methods for their preparation and use are disclosed. The compounds are useful analgesic and antiinflammatory agents.
    Type: Grant
    Filed: February 18, 1987
    Date of Patent: October 20, 1987
    Assignee: American Home Products Corporation
    Inventors: Dominick Mobilio, Christopher A. Demerson, Leslie G. Humber
  • Patent number: 4687860
    Abstract: Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives and methods for their preparation and use are disclosed. The compounds are useful analgesic and antiinflammatory agents.
    Type: Grant
    Filed: August 26, 1986
    Date of Patent: August 18, 1987
    Assignee: American Home Products Corporation
    Inventors: Dominick Mobilio, Christopher A. Demerson, Leslie G. Humber
  • Patent number: 4686213
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at position 8. The derivatives are useful anti-inflammatory and analgesic agents and methods and chemical intermediates for their preparation are also disclosed. Included are compounds of the formula ##STR1## wherein R.sup.1 is --H or lower alkyl containing 1 to 3 carbon atoms; R.sup.2 is --NH.sub.2, --NHCHO, --NHCONH.sub.2, --OCH.sub.3, oxo; R.sup.3 is --H or lower alkyl containing 1 to 3 carbon atoms and the pharmaceutically acceptable salts thereof when R.sup.1 is --H.
    Type: Grant
    Filed: August 15, 1986
    Date of Patent: August 11, 1987
    Assignee: American Home Products Corporation
    Inventors: Eckhardt S. Ferdinandi, Dominick Mobilio, Joseph P. Sabatucci, Leslie G. Humber
  • Patent number: 4670462
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at positions 5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: March 11, 1986
    Date of Patent: June 2, 1987
    Assignee: American Home Products Corporation
    Inventors: Alan H. Katz, Christopher A. Demerson, Leslie G. Humber
  • Patent number: 4622399
    Abstract: Herein is disclosed bicyclic-substituted aminoethanol derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions. The derivatives are useful for treating hypertension in a mammal.
    Type: Grant
    Filed: May 23, 1985
    Date of Patent: November 11, 1986
    Assignee: American Home Products Corporation
    Inventors: Andre A. Asselin, Danilo A. Crosilla, Leslie G. Humber
  • Patent number: 4616028
    Abstract: Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives and methods for their preparation and use are disclosed. The compounds are useful analgesic and antiinflammatory agents.
    Type: Grant
    Filed: November 13, 1985
    Date of Patent: October 7, 1986
    Assignee: American Home Products Corporation
    Inventors: Dominick Mobilio, Christopher A. Demerson, Leslie G. Humber