Patents by Inventor Leslie LaConte

Leslie LaConte has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring
    Patent number: 7459145
    Abstract: The present invention provides multifunctional magnetic nanoparticle probe compositions for molecular imaging and monitoring, comprising a nucleic acid or polypeptide probe, a delivery ligand, and a magnetic nanoparticle having a biocompatible coating thereon. The probe compositions may further comprise a fluorescent or luminescent resonance energy transfer moiety. Also provided are compositions comprising two or more such multifunctional magnetic nanoparticle probes for molecular imaging or monitoring. In particular, the nucleic acid or polypeptide probes bind to a target and generate an interaction observable with magnetic resonance imaging (MRI) or optical imaging. The invention thereby provides detectable signals for rapid, specific, and sensitive detection of nucleic acids, polypeptides, and interactions thereof in vivo.
    Type: Grant
    Filed: October 27, 2003
    Date of Patent: December 2, 2008
    Assignees: Georgia Tech Research Corporation, Emory University
    Inventors: Gang Bao, Shuming Nie, Nitin Nitin, Leslie LaConte
  • Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring
    Publication number: 20050130167
    Abstract: The present invention provides multifunctional magnetic nanoparticle probe compositions for molecular imaging and monitoring, comprising a nucleic acid or polypeptide probe, a delivery ligand, and a magnetic nanoparticle having a biocompatible coating thereon. The probe compositions may further comprise a fluorescent or luminescent resonance energy transfer moiety. Also provided are compositions comprising two or more such multifunctional magnetic nanoparticle probes for molecular imaging or monitoring. In particular, the nucleic acid or polypeptide probes bind to a target and generate an interaction observable with magnetic resonance imaging (MRI) or optical imaging. The invention thereby provides detectable signals for rapid, specific, and sensitive detection of nucleic acids, polypeptides, and interactions thereof in vivo.
    Type: Application
    Filed: October 27, 2003
    Publication date: June 16, 2005
    Inventors: Gang Bao, Shuming Nie, Nitin Nitin, Leslie LaConte