Patents by Inventor Leslie Muldoon

Leslie Muldoon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ADMINISTRATION OF A THIOL-BASED CHEMOPROTECTANT COMPOUND
    Publication number: 20200000844
    Abstract: A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver.
    Type: Application
    Filed: February 7, 2019
    Publication date: January 2, 2020
    Inventors: Edward A. Neuwelt, Leslie Muldoon, Michael A. Pagel
  • ADMINISTRATION OF A THIOL-BASED CHEMOPROTECTANT COMPOUND
    Publication number: 20180289737
    Abstract: A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver.
    Type: Application
    Filed: February 28, 2018
    Publication date: October 11, 2018
    Inventors: Edward A. Neuwelt, Leslie Muldoon, Michael A. Pagel
  • ADMINISTRATION OF A THIOL-BASED CHEMOPROTECTANT COMPOUND
    Publication number: 20170182089
    Abstract: A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver.
    Type: Application
    Filed: October 4, 2016
    Publication date: June 29, 2017
    Inventors: Edward A. Neuwelt, Leslie Muldoon, Michael A. Pagel
  • ADMINISTRATION OF A THIOL-BASED CHEMOPROTECTANT COMPOUND
    Publication number: 20160184353
    Abstract: A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver.
    Type: Application
    Filed: July 29, 2015
    Publication date: June 30, 2016
    Inventors: Edward A. Neuwelt, Leslie Muldoon, Michael A. Pagel
  • Administration of a thiol-based chemoprotectant compound
    Publication number: 20060177523
    Abstract: A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver.
    Type: Application
    Filed: November 14, 2005
    Publication date: August 10, 2006
    Applicants: Oregon Health & Science University, Government of The United States, d/b/a The Department of Veterans Affairs
    Inventors: Edward Neuwelt, Leslie Muldoon, Michael Pagel
  • Administration of a thiol-based chemoprotectant compound
    Patent number: 7022315
    Abstract: A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: April 4, 2006
    Assignees: Oregon Health & Science University, United States of America as represented by the Department of Veterans Affairs
    Inventors: Edward A. Neuwelt, Leslie Muldoon, Michael A. Pagel
  • Bone marrow protection with N-acetyl-L-cysteine
    Publication number: 20060020035
    Abstract: The present invention provides methods for preventing or ameliorating chemotherapeutic agent-induced bone marrow toxicity. These methods comprise administering an effective amount of N-acetyl-L-cysteine (L-NAC), alone or in combination with other agents, to a subject in need thereof. The present invention also provides compositions for preventing or ameliorating chemotherapeutic agent-induced bone marrow toxicity that comprises L-NAC.
    Type: Application
    Filed: March 11, 2005
    Publication date: January 26, 2006
    Applicant: Oregon Health & Science University
    Inventors: Edward Neuwelt, Leslie Muldoon
  • Administration of free radical scavengers to prevent or treat ischemia-reperfusion injuries
    Publication number: 20040132666
    Abstract: The present invention provides methods for preventing or reducing ischemia-reperfusion injuries. These methods comprise administering an effective amount of a free radical scavenger (e.g., N-acetylcysteine) to a subject in need thereof.
    Type: Application
    Filed: September 22, 2003
    Publication date: July 8, 2004
    Applicant: Oregon Health & Science University
    Inventors: Edward A. Neuwelt, Leslie Muldoon
  • Chemoprotectant for gastric toxicity
    Publication number: 20040062764
    Abstract: There is disclosed a method and pharmaceutical composition for treating or mitigating the side effects of cytotoxic cancer therapy for carcinoma-type cancers tumors including administering a thiol-based chemoproctectant agent and administering a cytotoxic agent having a targeting means to the Lewis Y glycoproteins.
    Type: Application
    Filed: August 18, 2003
    Publication date: April 1, 2004
    Inventors: Edward A. Neuwelt, Leslie Muldoon
  • Administration of a thiol-based chemoprotectant compound
    Publication number: 20030176359
    Abstract: A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver.
    Type: Application
    Filed: May 16, 2003
    Publication date: September 18, 2003
    Inventors: Edward A. Neuwelt, Leslie Muldoon, Michael A. Pagel