Patents by Inventor Leslie R. Coney

Leslie R. Coney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hepatitis C virus vaccine
    Patent number: 6831169
    Abstract: Nucleic acid molecule that comprise an incomplete hepatitis C viral genome are provided. Pharmaceutical compositions that contain nucleic acid molecules comprising an incomplete hepatitis C viral genome including a nucleotide sequence encoding a complete hepatitis C core protein operably linked to regulatory elements functional in human cells are provided. Methods of immunizing individuals susceptible to or infected by hepatitis C virus comprising the step of administering such pharmaceutical compositions are provided.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: December 14, 2004
    Assignee: The General Hospital Corporation
    Inventors: Catherine J. Pachuk, Jack Wands, Takaji Wakita, Vincent R. Zurawski, Jr., Leslie R. Coney
  • Hepatitis C virus vaccine
    Publication number: 20020161218
    Abstract: Nucleic acid molecule that comprise an incomplete hepatitis C viral genome including specifically disclosed DNA sequences are disclosed. Pharmaceutical compositions that contain nucleic acid molecules comprising an incomplete hepatitis C viral genome including a nucleotide sequence encoding a complete hepatitis C core protein operably linked to regulatory elements functional in human cells are disclosed.
    Type: Application
    Filed: May 1, 2001
    Publication date: October 31, 2002
    Applicant: Apollon, Inc.
    Inventors: Catherine J. Pachuk, Jack Wands, Takaji Wakita, Vincent R. Zurawski, Leslie R. Coney
  • Hepatitis C virus vaccine
    Patent number: 6235888
    Abstract: Nucleic acid molecule that comprise an incomplete hepatitis C viral genome including specifically disclosed DNA sequences are disclosed. Pharmaceutical compositions that contain nucleic acid molecules comprising an incomplete hepatitis C viral genome including a nucleotide sequence encoding a complete hepatitis C core protein operably linked to regulatory elements functional in human cells are disclosed. Methods of immunizing individuals susceptible to or infected by hepatitis C virus comprising the step of administering such pharmaceutical compositions are disclosed.
    Type: Grant
    Filed: June 5, 1997
    Date of Patent: May 22, 2001
    Assignees: The General Hospital Corporation, Apollon, Inc.
    Inventors: Catherine J. Pachuk, Jack Wands, Takaji Wakita, Vincent R. Zurawski, Jr., Leslie R. Coney
  • Ribozymes with linked anchor sequences
    Patent number: 6080851
    Abstract: Ribozymes are provided in which the ribozymes have a catalytic sequence, two legs and at least one anchor sequence complementary to the substrate mRNA at a location noncontiguous with the portions of the substrate mRNA complementary to the legs. In certain preferred embodiments, ribozymes capable of cleaving the L6 mRNA or both the L6 and K28 mRNAs are provided. Methods are provided for the treatment of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL) patients having the L6 and K28 translocations and, therefore, the L6 mRNA. Additionally, combination treatments comprising components specific for both the K28 and L6 mRNAs are provided. Combination treatments are also provided for those patients which express c-myc in combination with K28 and/or L6 mRNAs. Methods of treatment include, for example, administration of ribozymes and antisense oligonucleotides directed against these mRNAs.
    Type: Grant
    Filed: July 10, 1995
    Date of Patent: June 27, 2000
    Assignee: American Home Products Corporation
    Inventors: Catherine J. Pachuk, Leslie R. Coney, Fred T. Oakes