Abstract: Methods and compounds for conferring site-specific or local immune privilege, such as to the skin.

Abstract: In one aspect, the present disclosure provides a nozzle for a 3D printing system. The nozzle may include a flowpath with a material inlet and a material outlet. The nozzle may further include a valve in fluid communication with the flowpath between the material inlet and the material outlet, where the valve includes a closed state and an open state, where in the closed state the valve obstructs the flowpath between the material inlet and the material outlet, and where in the open state the material inlet is in fluid communication with the material outlet. The nozzle may further include a compensator in fluid communication with the flowpath, where the compensator includes a contracted state associated with the open state of the valve and an expanded state associated with the closed state of the valve.

Abstract: Embodiments provided herein, provide for variant IgG Fc polypeptides, dimeric molecules, pharmaceutical compositions, and methods that can be used to target at cells to modulate the activity of the same to treat disorders, such as autoimmune disorders or cancers.

Abstract: The present application provides for IL-2 muteins, compositions comprising the same, and methods of using the same.

Abstract: The present application provides for IL-2 muteins, compositions comprising the same, and methods of using the same.

Abstract: In one aspect, the present disclosure provides a nozzle for a 3D printing system. The nozzle may include a flowpath with a material inlet and a material outlet. The nozzle may further include a valve in fluid communication with the flowpath between the material inlet and the material outlet, where the valve includes a closed state and an open state, where in the closed state the valve obstructs the flowpath between the material inlet and the material outlet, and where in the open state the material inlet is in fluid communication with the material outlet. The nozzle may further include a compensator in fluid communication with the flowpath, where the compensator includes a contracted state associated with the open state of the valve and an expanded state associated with the closed state of the valve.

Abstract: The disclosure describes poly(?-thioester) polymers and polymeric nanoparticles, pharmaceutical compositions comprising these materials, their use in the treatment of cancer and infectious disease, and machine learning methods for identifying and selecting them.

Abstract: A method of removing contaminants from an aqueous solution includes providing a mixture of amorphous alumina silicate granules having a plurality of predefined sieve grades, where the mixture has enhanced molecular encapsulation compared to alumina silicate granules of a single sieve grade. An aqueous solution containing contaminant molecules is passed through the mixture of amorphous alumina silicate. The mixture of amorphous alumina silicate is disposed of, where the contaminant molecules from the aqueous solution are encapsulated within a plurality of pores of the mixture and ionically bonded to the amorphous alumina silicate.

Abstract: A spill control material has a combination of a pre-defined blended granule size mixture of amorphous alumina silicate in an aggregate blend of a plurality of predefined sieve grades where the combination has enhanced encapsulation properties greater than a single granule formulation. The pre-defined blended granule size mixture of amorphous alumina silicate has granules ranging in sizes larger than five microns and less than sixty-six microns in an aggregate blend of sieve grades #3 and #0.

Abstract: The systems and methods described herein relate to secure extranets which utilize certificate authentication to mediate access, transactions, and user tracking. Such extranets may be employed to provide an interface accessible over a network, such as the Internet, capable of authenticating and recording transactions for business, medical, or other purposes.

Abstract: The systems and methods described herein relate to secure extranets which utilize certificate authentication to mediate access, transactions, and user tracking. Such extranets may be employed to provide an interface accessible over a network, such as the Internet, capable of authenticating and recording transactions for business, medical, or other purposes.

Abstract: The systems and methods described herein relate to secure extranets which utilize certificate authentication to mediate access, transactions, and user tracking. Such extranets may be employed to provide an interface accessible over a network, such as the Internet, capable of authenticating and recording transactions for business, medical, or other purposes.

Abstract: A means and method of facilitating charitable contributions through an interactive social media networking community website with advertising, contribution, and distribution functions is disclosed. The current invention is designed to maximize charitable contributions and allow for a custom-tailored distribution scheme that more effectively raises and distributes charitable contributions that is offered by any of the currently available charities.

Abstract: A spill control material has a combination of a pre-defined blended granule size mixture of amorphous alumina silicate in an aggregate blend of a plurality of predefined sieve grades where the combination has enhanced encapsulation properties greater than a single granule formulation. The pre-defined blended granule size mixture of amorphous alumina silicate has granules ranging in sizes larger than five microns and less than sixty-six microns in an aggregate blend of sieve grades #3 and #0.

Abstract: Embodiments of the disclosure provide a saw chain having cutter links having a cutting edge on a first end and an opposite second end adapted for riding on or along a rail of a guide bar. First drive links are coupled with the cutter links and are adapted to ride in a groove of a guide bar. The first drive links have a clean out tang sized and shaped to scoop debris from within the groove, and have two first drive link side surfaces on opposite sides thereof adapted to have at least occasional wearing contact with interior side walls of the groove. Second drive links are coupled with the first drive links and the cutter links, and are adapted to ride in the groove of the guide bar. Each second drive link has second drive link side surfaces adapted to have at least occasional wearing contact with the interior side walls of the groove. The second drive link side surfaces have a greater surface area than the first drive link side surfaces, and in some embodiments may be featured rudder links.

Abstract: The systems and methods described herein relate to secure extranets which utilize certificate authentication to mediate access, transactions, and user tracking. Such extranets may be employed to provide an interface accessible over a network, such as the Internet, capable of authenticating and recording transactions for business, medical, or other purposes.

Abstract: A saw chain for cutting hard abradable material is shown and described. The saw chain cuts with an abrasive particle impregnated mesh structure. In one embodiment, the saw chain has right and left support links carrying the diamond mesh upon inclined support surfaces inclined relative to the travel axis of the saw chain. The abrasive particle impregnated mesh contacts the material to be cut only adjacent its trailing edge. A consumable material exists between the impregnated mesh and the support surface. The impregnated mesh may extend downward along the side of the support link to maintain a constant kerf width. In another embodiment, a formed cover is mounted on joined side link pairs of the saw chain. The cover has an abrasive particle impregnated mesh on an inclined surface and on select areas of its side skirts. The skirts cover as least a portion of the bores in the drive links and support links to retain and protect the fasteners therein.

Abstract: An abrasive cutting apparatus including a cutting chain formed of pivotally connected links is described for cutting rock, concrete and the like. The abrasive cutting chain is inverted so that its cutter links having abrasive cutting elements fixed thereto face inwardly of the endless loop of chain. A motor driven drive pulley having a groove which may be provided with an elastomer liner, engages the cutter links to drive the chain. A pair of idler pulleys with grooves that engage an outward projection on each of the center links of the chain guide the movement of the chain to provide lateral stability and proper tension to such chain. A releasable connection formed by a pair of connector side links and a connector pin with intermediate portions of reduced diameter, is employed to connect chain sections of standard length to form an endless chain of adjustable length and to enable replacement of broken sections in the field manually without the use of special tools.

Abstract: A cutting saw chain for aggregate materials including a loop of articulated chain links adapted to fit the guide bar of a chain saw. The guide bar is provided with a flushing system whereby pressurized water is directed through the bar and into the path of the guided saw chain to cool the chain and flush away debris formed in the cutting operation. The cutting link structure is a folded plate-like member formed into spaced side plate portions and an overhead connecting web. The side plate portions function like side links in a conventional saw chain and ride on the rails of the guide bar. Rivet holes are formed in the side plate portions. Rivets projected through the rivet holes connect the side plate portions to front and rear center links. The side plate portions are fixed in spaced relation by the connecting web an permits the use of rivets with straight shank. The connecting web supports front and rear sections of a cutting block.