Patents by Inventor Lewis R. Silverman

Lewis R. Silverman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia
    Patent number: 8664272
    Abstract: Methods and compositions are provided for treating myelodysplastic syndrome and acute myeloid leukemia, wherein the composition comprises at least one compound according to Formula I: wherein R1 is selected from the group consisting of —NH2, —NH—CH2—CO2H, —NH—CH(CH3)—CO2H, and —NH—C(CH3)2—CO2H, or a pharmaceutically acceptable salt of such a compound; and a DNA methyltransferase inhibitor, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 30, 2006
    Date of Patent: March 4, 2014
    Assignees: Temple University—Of the Commonwealth System of Higher Education, Icahn School of Medicine at Mount Sinai
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy, James F. Holland, Lewis R. Silverman, Svetlana Zinzar
  • COMPOSITION AND METHODS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROME AND ACUTE MYELOID LEUKEMIA
    Publication number: 20100305059
    Abstract: Methods and compositions are provided for treating myelodysplastic syndrome and acute myeloid leukemia, wherein the composition comprises at least one compound according to Formula I: wherein R1 is selected from the group consisting of —NH2, —NH—CH2—CO2H, —NH—CH(CH3)—CO2H, and —NH—C(CH3)2—CO2H, or a pharmaceutically acceptable salt of such a compound; and a DNA methyltransferase inhibitor, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 30, 2006
    Publication date: December 2, 2010
    Applicant: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: E. Premkumar Reddy, M.V. Ramana Reddy, James F. Holland, Lewis R. Silverman, Svetlana Zinzar