Abstract: Improved systematic inversion methodology applied to formation testing data interpretation with spherical, radial and/or cylindrical flow models is disclosed. A method of determining a parameter of a formation of interest at a desired location comprises directing a formation tester to the desired location in the formation of interest and obtaining data from the desired location in the formation of interest. The obtained data relates to a first parameter at the desired location of the formation of interest. The obtained data is regressed to determine a second parameter at the desired location of the formation of interest. Regressing the obtained data comprises using a method selected from a group consisting of a deterministic approach, a probabilistic approach, and an evolutionary approach.

Abstract: This disclosure provides a method of determining a pore throat size distribution of reservoir rock, comprising injecting a set of different-sized probe particles through a portion of reservoir rock and measuring retention volumes or times of each of the different-sized probe particles eluting from the portion of reservoir rock. This disclosure also provides a testing apparatus comprising a probe tube for receiving a set of different-sized probe particles in an elution fluid returning from a portion of reservoir rock and an analytical module connected to receive the elution fluid from the probe tube.

Abstract: A (Z)-solanone has the steric formula of: or with the name of (S,Z)-5-isopropyl-8-methyl-6,8-diene-2-one or (R,Z)-5-isopropyl-8-methyl-6,8-diene-2-one. A process for the preparation of the (Z)-type solanone and the use thereof in flavoring of cigarette shred are further disclosed. The process includes the following steps: (1) reacting isopentanal and methyl vinyl ketone, under the action of a catalyst and a co-catalyst, to give (S)-2-isopropyl-5-carbonylhexanal or (R)-2-isopropyl-5-carbonylhexanal; (2) reacting the (S)-2-isopropyl-5-carbonylhexanal or the (R)-2-isopropyl-5-carbonylhexanal obtained in step (1) with (iodomethyl)triphenylphosphonium iodide, to give (S,Z)-7-iodo-5-isopropyl-6-ene-2-one or (R,Z)-7-iodo-5-isopropyl-6-ene-2-one; and (3) reacting the (S,Z)-7-iodo-5-isopropyl-6-ene-2-one or the (R,Z)-7-iodo-5-isopropyl-6-ene-2-one obtained in step (2) with pinacol isopropenylborate in the presence of a catalyst to give the (Z)-solanone.

Abstract: A (Z)-solanone has the steric formula of: with the name of (S,Z)-5-isopropyl-8-methyl-6,8-diene-2-one or (R,Z)-5-isopropyl-8-methyl-6,8-diene-2-one. A process for the preparation of the (Z)-type solanone and the use thereof in flavoring of cigarette shred are further disclosed. The process includes the following steps: (1) reacting isopentanal and methyl vinyl ketone, under the action of a catalyst and a co-catalyst, to give (S)-2-isopropyl-5-carbonylhexanal or (R)-2-isopropyl-5-carbonylhexanal; (2) reacting the (S)-2-isopropyl-5-carbonylhexanal or the (R)-2-isopropyl-5-carbonylhexanal obtained in step (1) with (iodomethyl)triphenylphosphonium iodide, to give (S,Z)-7-iodo-5-isopropyl-6-ene-2-one or (R,Z)-7-iodo-5-isopropyl-6-ene-2-one; and (3) reacting the (S,Z)-7-iodo-5-isopropyl-6-ene-2-one or the (R,Z)-7-iodo-5-isopropyl-6-ene-2-one obtained in step (2) with pinacol isopropenylborate in the presence of a catalyst to give the (Z)-solanone.

Abstract: Disclosed is an SOMCL-9112 solid dispersion. The SOMCL-9112 solid dispersion is characterized by being prepared from the following raw materials in percentage by weight: 5 percent to 60 percent of SOMCL-9112, 5 percent to 90 percent of pharmaceutically acceptable matrix polymer, 0 percent to 20 percent of surfactant, 0 percent to 20 percent of flow aid and 0 percent to 20 percent of plasticizer. Also disclosed are a preparation method of the SOMCL-9112 solid dispersion, a solid medicinal preparation containing the solid dispersion and application of the solid dispersion for preparing a medicine for treating cancer.

Abstract: This disclosure presents systems to enable downhole bi-directional communications using a long length of fiber optic cable located within or partially within the internal diameter of a set of lower pipe segments and communicatively coupled to one or more upper pipe segments that utilize pipe cable attached to the outside diameter of each of the upper pipe segments. The long length of fiber optic cable and the one or more pipe cables from the upper pipe segments allow for communication coupling between downhole tools and surface equipment and surface computing systems. In some aspects, the pipe cable attached to the upper pipe segments can be protected from wear using clamps, collars, cages, and other protectors. In some aspects, an optical signal generator and modulator, e.g., a light source, can be located downhole proximate the downhole tools, uphole proximate one of the upper pipe segments, or proximate the surface equipment.

Abstract: A method for increasing biomass and sugar yield of a plant comprising: transforming a plant with a first gene that is functional in a plant, wherein said gene is pleitropic, and wherein said plant overexpresses said gene, thereby increasing biomass and sugar yield; producing said plant through molecular breeding using information of said gene; and cultivating said plant.

Abstract: This disclosure presents systems to enable downhole bi-directional communications using a long length of electrical cable located within or partially within the internal diameter of a set of lower pipe segments and communicatively coupled to one or more upper pipe segments that utilize pipe cable attached to the outside diameter of each of the upper pipe segments. The long length of electrical cable and the one or more pipe cables from the upper pipe segments allow for communication coupling between downhole tools and surface equipment and surface computing systems. In some aspects, the pipe cable attached to the upper pipe segments can be protected from wear using clamps, collars, cages, and other protectors. In some aspects, an electrical signal generator and modulator can be located downhole proximate the downhole tools, uphole proximate one of the upper pipe segments, or proximate the surface equipment.

Abstract: In one embodiment, the apparatus includes a production tubing for carrying fluids from a producing zone to a surface, and a three-way valve coupled to the production tubing, the three-way valve including an inlet from the production tubing, an outlet to the production tubing, and an inlet from the borehole surrounding the three-way valve. The apparatus further includes a resonant tube densitometer disposed in the outlet to the production tubing, the resonant tube densitometer configured to measure the density of the fluids. A flow meter is disposed in the outlet to the production tubing, the flow meter configured to measure volumetric flow of the fluids.

Abstract: An apparatus, system, and method are disclosed herein. In one embodiment, the apparatus includes a plurality of valves. Each valve of the plurality of valves is associated with a respective production zone of a well. Each valve includes a valve body having a passage and an inflow fluid input through which a formation fluid from the respective production zone associated with the valve is to enter the passage of the valve body. Each valve further includes a sensor located within the valve body to detect a density of the formation fluid. The apparatus further includes a processor programmed to determine a fraction of a subject fluid in the formation fluid based on the density of the formation fluid and a density of the subject fluid.

Abstract: Gas bubble migration can be managed in liquids. In one example, a system can execute wellbore-simulation software to simulate changes in gas dissolution in a liquid over time. This may involve dividing the wellbore into segments spanning from the well surface to the downhole location, each segment spanning a respective depth increment between the well surface and the downhole location. Next, for each time, the system can determine a respective multiphase-flow regime associated with each segment of the plurality of segments based on a simulated pressure level, a simulated temperature, a simulated pipe eccentricity, and a simulated fluid velocity at the segment. The system can also determine how much of the gas is dissolved in the liquid at each segment based on the respective multiphase-flow regime at the segment. The system can display a graphical user interface representing the gas dissolution in the liquid over time.

Abstract: Provided are tissue-mounted devices and methods for monitoring a thermal transport property (e.g., thermal conductivity, thermal diffusivity, heat capacity) of tissue, such as skin. The devices conformally mount to the tissue and have one or more thermal actuators and a plurality of sensors. The actuator applies heat to the tissue and the sensors to detect a spatio temporal distribution of a physiological tissue parameter or physical property resulting from the heating. This spatio temporal information may be correlated with a rate, velocity and/or direction of blood flow, the presence of a vascular occlusion, circulation changes due to inflammation, hydration level and other physiological parameters.

Abstract: Improved systematic inversion methodology applied to formation testing data interpretation with spherical, radial and/or cylindrical flow models is disclosed. A method of determining a parameter of a formation of interest at a desired location comprises directing a formation tester to the desired location in the formation of interest and obtaining data from the desired location in the formation of interest. The obtained data relates to a first parameter at the desired location of the formation of interest. The obtained data is regressed to determine a second parameter at the desired location of the formation of interest. Regressing the obtained data comprises using a method selected from a group consisting of a deterministic approach, a probabilistic approach, and an evolutionary approach.

Abstract: Systems and methods for determining the composition of a drilling fluid using electro-rheology may be provided. A method for drilling a wellbore may include: circulating a drilling fluid in a wellbore; extending the wellbore into one or more subterranean formations; measuring impedance of at least a portion of the drilling fluid over time as one or more particulate additives in the drilling fluid settle; determining one or more model elements of an equivalent circuit model for modeling frequency responses of the drilling fluid from the impedance; and determining sag behavior of the drilling fluid based, at least partially, on the one or more model elements.

Abstract: A system and method for signal communication using a piezoelectric fiber composite (PFC) sensor. A telemetry module is locatable within a borehole intersecting a subterranean earth formation. The PFC sensor is coupled to a carrier in communication with the telemetry module. The PFC sensor is configured to generate a signal indicative of a stress in the carrier. A processor in communication with the PFC sensor is configured to convert the signal generated by the PFC sensor into a telemetry signal transmitted by the telemetry module.

Abstract: A formation test probe and a formation test system and method for implementing a self-drilling probe are disclosed. In some embodiments, a test probe includes a body having a channel therethrough to a frontside port, and further includes drill-in tubing disposed within the channel and having a front tip that is extensible from the frontside port. An exciter is disposed within the body in contact with the drill-in tubing and operably configured to induce resonant vibration in the drill-in tubing during a drill-in phase of a formation test cycle.

Abstract: Systems and methods for measurement of the oil, water, and/or solids concentration in oil-based drilling fluids may be provided in accordance with embodiments of the present disclosure. An example method for monitoring oil-based drilling fluids may include providing a sample of an oil-based drilling. The method may further include determining an estimate of an oil concentration of the sample. The method may further include measuring thermal conductivity of the sample. The method may further include determining an estimate of solids concentration of the sample from a correlation that relates the oil concentration, the thermal conductivity, and the solids concentration.

Abstract: Methods and systems for using a cooling apparatus comprising an elastocaloric material to reduce the temperature of downhole packages in a subterranean formation are provided herein. In one or more embodiments, the methods of the present disclosure comprise: disposing a downhole package in a wellbore penetrating a portion of a subterranean formation; and disposing a cooling apparatus comprising an elastocaloric material and at least one actuator downhole in the wellbore, wherein the cooling apparatus is adjacent to the downhole package. In one or more embodiments, the systems of the present disclosure comprise: a downhole package having a temperature; and a cooling apparatus coupled to the downhole package, wherein the cooling apparatus comprises an elastocaloric material coupled to at least one actuator, wherein the cooling apparatus is configured to reduce the temperature of the downhole package.

Abstract: The present invention relates to the field of medical biology, and discloses a single domain antibody and derivative proteins thereof against CTLA4. In particular, the present invention discloses a CTLA4 binding protein and the use thereof, especially the use for treating and/or preventing CTLA4 relevant diseases such as tumor.

Abstract: An acoustic receiver is provided. The acoustic receiver includes an optical vibrometer having an optical emitter and an optical receiver. The optical receiver is operable to emit an optical beam to a single point of reference on a conduit, and the optical receiver is operable to receive one or more reflections of the optical beam off of the single point of reference on the conduit, thereby detecting waves propagating through the conduit created by an acoustic transmitter. A processor is coupled with the optical emitter and the optical receiver. The processor is operable to: determine components of the waves created by the acoustic transmitter based on the one or more reflections of the optical beam; and determine a signal transmitted from the acoustic transmitter based on the components of the waves.