Patents by Inventor Li-How Chen

Li-How Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel modified MSP-1 nucleic acid sequences and methods for increasing mRNA levels and protein expression in cell systems
    Publication number: 20020144299
    Abstract: The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of malarial surface protein MSP-1 which is known to be difficult to express in cell culture systems, mammalian cell culture systems, or in transgenic animals. The preferred protein candidates for expression using the recombinant techniques of the invention are MSP-1 proteins expressed from DNA coding sequences comprising reduced overall AT content or AT rich regions and/or mRNA instability motifs and/or rare codons relative to the native MSP-1 gene.
    Type: Application
    Filed: February 20, 2002
    Publication date: October 3, 2002
    Applicant: Genzyme Transgenics Corporation, a Massachusetts corporation
    Inventors: Li How Chen, Harry M. Meade