Abstract: A display substrate, a manufacturing method therefor, and a display device are provided. The display substrate includes a base substrate, sub-pixels and an isolation portion, and each sub-pixel includes a light-emitting function layer. The isolation portion includes a first sub-isolation portion and a second sub-isolation portion. The first sub-isolation portion is between the second sub-isolation portion and the base substrate. The second sub-isolation portion includes a protrusion protruding relative to an edge of the first sub-isolation portion, the second sub-isolation portion facing one of adjacent sub-pixels is different in shape from the second sub-isolation portion facing the other one; or, a slope angle between a side surface of the first sub-isolation portion or the second sub-isolation portion facing one sub-pixel and a plane parallel to the base substrate is 60° to 120°. At least one film of the light-emitting function layer is disconnected at the isolation portion.

Abstract: This application relates to the artificial intelligence field, and discloses a neural network search method and a related apparatus. The neural network search method includes: constructing attention heads in transformer layers by sampling a plurality of candidate operators during model search, to construct a plurality of candidate neural networks, and comparing performance of the plurality of candidate neural networks to select a target neural network with higher performance. In this application, a transformer model is constructed with reference to model search, so that a new attention structure with better performance than an original self-attention mechanism can be generated, and effect in a wide range of downstream tasks is significantly improved.

Abstract: A method for growing bulk boron arsenide (BA) crystals, the method comprising utilizing a seeded chemical vapor transport (CVT) growth mechanism to produce single BAs crystals which are used for further CVT growth, wherein a sparsity of nucleation centers is controlled during the further CVT growth. Also disclosed are bulk BAs crystals produced via the method.

Abstract: This application discloses a model training method, which may be applied to the field of artificial intelligence. The method includes: when training a first neural network model based on a training sample, determining N parameters from M parameters of the first neural network model based on a capability of affecting data processing precision by each parameter; and updating the N parameters. In this application, on a premise that it is ensured that the data processing precision of the model meets a precision requirement, because only N parameters in M parameters in an updated first neural network model are updated, an amount of data transmitted from a training device to a terminal device can be reduced.

Abstract: Provided herein are compounds of the Formula (I): (I) and tautomers, stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein Rx, Ry, W, X, Y, Z, Ring A and (AA) have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: The present disclosure relates generally to compounds and compositions thereof for inhibition of ErbB2, including mutant forms of ErbB2, particularly those harboring an Exon 20 mutation, methods of preparing said compounds and compositions, and their use in the treatment or prophylaxis of various cancers, such as lung, glioma, skin, head neck, salivary gland, breast, esophageal, liver, stomach (gastric), uterine, cervical, biliary tract, pancreatic, colorectal, renal, bladder or prostate cancer.

Abstract: A gas extraction device for metal mineral inclusions and a gas extraction method therefor are provided, the device includes a base plate, an annular carrier, sealing covers, a grinding assembly, a vacuum assembly, a gas-gathering assembly and a mass spectrometer. The annular carrier is disposed on the base plate, multiple grinding chambers are defined and evenly distributed in a circular shape on the annular carrier, the sealing covers are disposed at openings of the grinding chambers, the grinding assembly includes grinding hammers, and the grinding hammers penetrate through the sealing covers and extend into the grinding chambers. Side walls of each grinding chamber defines a first through hole and a second through hole. The vacuum assembly is communicated with the grinding chambers through the first through holes. The gas-gathering assembly is communicated with the grinding chambers through the second through holes. The mass spectrometer is communicated with the gas-gathering assembly.

Abstract: A bottom cylinder for a high-temperature and high-pressure environment simulator of a high-fidelity corer is provided. The bottom cylinder includes a cylinder barrel. The bottom of the cylinder barrel is provided with a cylinder base. The piston is provided inside the cylinder barrel and divides an inner cavity of the cylinder barrel into a rodless cavity and a rod cavity. The piston is provided with a piston rod. The outer wall of the cylinder barrel is provided with an oil inlet hole communicated with the rodless cavity, an oil outlet hole communicated with the rod cavity, and a reserved hole. The lower end surface of the piston is provided with a first buffer ring, and the upper surface of the cylinder base is provided with a second buffer ring mated with the first buffer ring. The bottom cylinder is applied to the simulator for oil and gas resource exploitation.

Abstract: The present application relates to a method for detecting the content of a glycosaminoglycan carboxylated derivative in a sample, and an application thereof.

Abstract: A semiconductor structure includes a semiconductor on insulator (SOI) substrate, a first electrically conductive structure, and a second electrically conductive structure. The SOI substrate includes a base substrate, a buried insulation layer disposed on the base substrate, a semiconductor layer disposed on the buried insulation layer, and a trap rich layer disposed between the buried insulation layer and the base substrate. At least a part of the first electrically conductive structure and at least a part of the second electrically conductive structure are disposed in the trap rich layer. A part of the trap rich layer is disposed between the first electrically conductive structure and the second electrically conductive structure. The first electrically conductive structure, the second electrically conductive structure, and the trap rich layer disposed between the first electrically conductive structure and the second electrically conductive structure are at least a portion of an anti-fuse structure.

Abstract: Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: The present invention relates to nucleic acids, double stranded nucleic acids (dsNAs), and agents for inhibiting expression of STATS. The present invention also includes nanoparticles comprising the nucleic acids, the dsNAs, and/or the agents as well as methods of treating cancer using the nucleic acids, the double stranded nucleic acids (dsNAs), the agents and/or the nanoparticles as disclosed herein. In one embodiment, the target region is within the 3?-UTR region of STATS mRNA.

Abstract: The present disclosure relates to compounds and compositions for inhibition of Bcr-Abl tyrosine kinases, methods of preparing said compounds and compositions, and their use in the treatment of various cancers, such as chronic myeloid leukemia (CML).

Abstract: The invention relates to a method of treating a MEK-associated tumor by administering to a subject in need thereof a therapeutically effective amount of a solid form 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.

Abstract: Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X1, X2, X3 and X4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase.

Abstract: The present disclosure relates generally to compounds and compositions thereof for inhibition of ErbB2, including mutant forms of ErbB2, particularly those harboring an Exon 20 mutation, methods of preparing said compounds and compositions, and their use in the treatment or prophylaxis of various cancers, such as lung, glioma, skin, head neck, salivary gland, breast, esophageal, liver, stomach (gastric), uterine, cervical, biliary tract, pancreatic, colorectal, renal, bladder or prostate cancer.

Abstract: A high-temperature and high-pressure simulator for a deep in-situ environment is provided. The simulator includes a high-fidelity sample chamber, where a lower end of the high-fidelity sample chamber is provided with a bottom cylinder. A lower end of the bottom cylinder is provided on a base. A piston rod of the bottom cylinder extends into the high-fidelity sample chamber, and an upper end of the piston rod is provided with a rock sample seat. An upper end of the high-fidelity sample chamber is provided with a rock sample cap. The top of the high-fidelity sample chamber is sealed by an end cap of the high-fidelity sample chamber. An upper end of the end cap of the high-fidelity sample chamber is provided with a multi-section coring drill chamber. The uppermost section of the coring drill chamber is connected to a lift cylinder.

Abstract: The present disclosure relates to compounds and compositions for inhibition of Bcr-Abl tyrosine kinases, methods of preparing said compounds and compositions, and their use in the treatment of various cancers, such as chronic myeloid leukemia (CML).

Abstract: The present disclosure relates generally to compounds and compositions thereof for inhibition of ErbB2, including mutant forms of ErbB2, particularly those harboring an Exon 20 mutation, methods of preparing said compounds and compositions, and their use in the treatment or prophylaxis of various cancers, such as lung, glioma, skin, head neck, salivary gland, breast, esophageal, liver, stomach (gastric), uterine, cervical, biliary tract, pancreatic, colorectal, renal, bladder or prostate cancer.

Abstract: The present disclosure relates to compounds and compositions for inhibition of Bcr-Abl tyrosine kinases, methods of preparing said compounds and compositions, and their use in the treatment of various cancers, such as chronic myeloid leukemia (CML).