Abstract: The present invention relates to the field of biomedicine, and in particular to a use of goji glycopeptide in the preparation of a drug for preventing and/or treating amyotrophic lateral sclerosis. Experimental results prove the use of goji glycopeptide in the preparation of a drug for preventing and/or treating amyotrophic lateral sclerosis.

Abstract: Methods, systems and apparatus for video processing are described. One example video processing method includes performing a conversion between a video including a video region and a bitstream of the video according to a rule, wherein the rule specifies that an adaptive loop filtering operation is allowed for the video region in response to an absence of one or more adaptation parameter set (APS) network abstraction layer (NAL) units that include adaptive loop filtering data.

Abstract: Provided are an RNA plasmid delivery system and an application thereof. The RNA plasmid delivery system comprises a plasmid carrying an RNA fragment required to be delivered; the plasmid can be enriched in an organ tissue of a host, and spontaneously forms an exosome containing the RNA fragment in the organ tissue of the host, and therefore can enter and be combined with a target tissue to deliver the RNA fragment into the target tissue. The RNA delivery system is safe, reliable, good in druggability, and strong in universality.

Abstract: Embodiments of the present disclosure provide a solution for video processing. A method for video processing is proposed. The method comprises: determining, during a conversion between a target video block of a video and a bitstream of the video, a cost metric for a target motion candidate for the target video block at least based on a matching cost of the target motion candidate; and performing the conversion based on a comparison of the cost metric and a further matching cost for the target video block. Compared with the conventional solution, the proposed method can advantageously improve the coding effectiveness and coding efficiency.

Abstract: A pixel driving circuit includes: a data writing circuit, a compensation control circuit, a light emission control circuit, a voltage regulation circuit, a driving transistor, the compensation control circuit is connected with the driving transistor at a first node, the compensation control circuit is connected with the data writing circuit at a second node, the compensation control circuit, the light emission control circuit, the voltage regulation circuit are connected with the driving transistor at a third node; the compensation control circuit obtains a threshold voltage of the driving transistor, writes a third voltage into the second node, and writes a light emission voltage into the first node according to a variation in a voltage at the second node and the threshold voltage; the voltage regulation circuit maintains a voltage at the third node stable during the compensation control circuit writing the light emission voltage into the first node.

Abstract: An RNA delivery system for the treatment of Huntington's disease. The system comprises a viral vector, the viral vector carries RNA fragments capable of treating Huntington's disease, the viral vector is capable of enrichment in organ tissues of a host and endogenously and spontaneously forming a complex containing the RNA fragments capable of treating Huntington's disease in the organ tissues of the host, and the complex can deliver the RNA fragments into a target tissue to treat Huntington's disease. The safety and reliability of the RNA delivery system for the treatment of Huntington's disease have been fully verified. The system has good medicinal properties, strong versatility, and has economic benefits and application prospects.

Abstract: Provided is an isolated antigen-binding protein, wherein the drug is used for the treatment of tumor, and the isolated antigen-binding protein comprises a PD-L1 binding moiety and an OX40 binding moiety, wherein: the OX40 binding moiety is capable of recognizing and/or binding amino acid residues G70 and/or F71 in a human OX40 extracellular domain; and the PD-L1 binding moiety is capable of recognizing and/or binding amino acid residues I54, Y56, E58, Q66 and/or R113 in an N-terminal IgV domain of human PD-L1. Further provided is a use of the isolated antigen-binding protein in preparing a drug, wherein the drug is used for the treatment of tumors.

Abstract: The present disclosure relates to a nitrogen-doped porous carbon material and a preparation method and use thereof. In the present disclosure, the preparation method of a nitrogen-doped porous carbon material includes the following steps: conducting carbonization on a biomass material to obtain a carbon source; and mixing the carbon source with a potassium 4-aminobenzoate aqueous solution, and drying and conducting calcination in a protective atmosphere sequentially to obtain the nitrogen-doped porous carbon material. In the preparation method, the potassium 4-aminobenzoate is used as a nitrogen source as well as an activator for preparing the nitrogen-doped porous carbon material. Nitrogen doping is simultaneously completed during the activation, and the nitrogen-doped porous carbon material can be prepared through one-step calcination.

Abstract: Provided are a viral vector-based RNA delivery system and a use thereof. The RNA delivery system comprises a viral vector. The viral vector carries an RNA fragment needing to be delivered, and can be enriched in organ tissues of a host. In the host organ tissues, the viral vector can endogenously and spontaneously form a composite structure containing the RNA fragment. The composite structure can enter and bind to target tissues, and feed the RNA fragment into the target tissues. The viral vector has a targeting tag. The composite structure is an exosome. The viral vector RNA delivery system is safe and reliable, and has good druggability and high universality.

Abstract: Several techniques for video encoding and video decoding are described. One example method includes performing a conversion between a video picture of a video comprising one or more slices and a bitstream of the video picture according to a rule. The rule specifies that that whether a first syntax element indicating a usage of a coding tool is present at a first level is based on a syntax flag indicating whether a syntax structure of a second level is not present at the first level, wherein the second level is higher than the first level, and wherein the second level is the video picture level or higher than the video picture level.

Abstract: Embodiments of the present disclosure provide a method for video processing. The method comprises: determining, during a conversion between a current video block of a video and a bitstream of the video, a geometric partition mode (GPM) partition index for the current video block, the GPM partition index being absent from the bitstream; and performing the conversion based on the GPM partition index. Compared with conventional solutions, the proposed method can advantageously reduce the coding bits while maintaining the coding quality.

Abstract: Devices, systems, and methods for palette mode coding are described. An exemplary method for video processing includes performing a conversion between a block of a video and a bitstream representation of the video. The bitstream representation is processed according to a format rule that specifies a first indication of usage of a palette mode and a second indication of usage of an intra block copy (IBC) mode are signaled dependent of each other.

Abstract: Provided are a gene circuit, an RNA delivery system and the use thereof. Specifically, the gene circuit comprises at least an RNA fragment capable of inhibiting gene expression and/or a targeting tag having a targeting function. The gene circuit can be delivered to a host, enriched in organ tissues of the host and self-assembled to form a complex structure, and inhibits gene expression by means of the RNA fragment, thereby treating diseases. The delivery system comprises the gene circuit and a delivery carrier capable of delivering the gene circuit to organ tissues of a host for enrichment. The provided gene circuit has a targeting function and a treatment function, can quickly and accurately reach target organs and target tissues to exert a treatment effect, and is highly efficient with good results. The safety and reliability of the provided RNA delivery system are fully verified, and the RNA delivery system has good druggability, high universality, and great economic benefits and application prospects.

Abstract: This application discloses a model training method, which may be applied to the field of artificial intelligence. The method includes: when training a first neural network model based on a training sample, determining N parameters from M parameters of the first neural network model based on a capability of affecting data processing precision by each parameter; and updating the N parameters. In this application, on a premise that it is ensured that the data processing precision of the model meets a precision requirement, because only N parameters in M parameters in an updated first neural network model are updated, an amount of data transmitted from a training device to a terminal device can be reduced.

Abstract: An example method of video processing includes determining, for a conversion between a block of a chroma component of a video and a bitstream representation of the video, whether or how to apply a filtering process to an edge of the block based on a first quantization information for a first video region comprising samples on one side of the edge and/or a second quantization information for a second video region comprising samples on the other side of the edge according to a rule that is based on a coding mode applicable to the block for coding the samples on the one side or the samples on the other side of the edge. The rule specifies that multiple QP offsets at different video unit levels are used to determine the first quantization information or the second quantization information. The method also includes performing the conversion based on the determining.

Abstract: A method of video processing is described. The method includes: deriving, for a conversion between a current block of a video and a coded representation of the video, a prediction block for the current block that is determined according to a tool in which weights are used to determine a weighted sum of two initial prediction blocks used to determine the prediction block; and performing the conversion using the prediction block; wherein the deriving includes: applying the weights to two intermediate prediction samples that respectively belong to the two initial prediction blocks to derive a final prediction sample; and performing a right shift operation for the final prediction sample, wherein the right shift operation is pbSample>> (shift1+3)), wherein pbSample represents the final prediction sample, shift1 is set equal to Max(2, 14?bitDepth); and determining the prediction block based on the final prediction sample.

Abstract: Devices, systems and methods for processing video are described. In a representative aspect, a video processing method is provided to include: maintaining tables, wherein each table includes a set of motion candidates and each motion candidate is associated with corresponding motion information; performing a conversion between a first video block and a bitstream representation of a video including the first video block based on the tables; and updating, after performing of the conversion, zero or more tables, based on an update rule.

Abstract: The present application provides a method for detecting a broken fanout wire of a display substrate, and a display substrate, and belongs to the field of display technology. In the method for detecting a broken fanout wire, the display substrate includes a base substrate having first and second surfaces opposite to each other, and a plurality of connection structures disposed at intervals on the first surface; and each connection structure includes first and second pads and a fanout wire electrically connecting the first pad to the second pad. The method for detecting a broken fanout wire includes: forming at least one detection unit, which includes: connecting at least two connection structures in series through a connecting part; and measuring a head and an end of the detection unit to obtain resistance of the detection unit, and determining whether there is a broken fanout wire in the detection unit.

Abstract: A method for detecting and compensating CNC tools being implemented in an electronic device, receives from a detector first parameters and second parameters in respect of a first tool. Such first parameters include at least one of service life, blade break information, and blade chipping information of the first tool, and such second parameters include at least one of length extension information, length wear information, radial wear information, and blade thickness wear information of the first tool. Based on the first parameters, instructions to process the workpiece are transmitted or not. Upon receiving the second parameters, instructions to adjust operation of the first tool are transmitted, to compensate for deterioration in normal use.

Abstract: A display substrate and a manufacturing method and a display device are provided. The display substrate includes: a base substrate, a first insulation layer, a first electrode pattern, a connecting electrode pattern, a second electrode, a light-emitting functional layer, and a first filling layer. The second electrode is connected with the connecting electrode pattern, the second electrode and the first electrode pattern are spaced apart from each other. The light-emitting functional layer is located between the first electrode pattern and the second electrode. The first filling layer is located between the connecting electrode pattern and the first electrode pattern. The first filling layer and the light-emitting functional layer are different layers; a portion of the first insulation layer that is located between the first electrode pattern and the connecting electrode pattern has a groove, and the first filling layer is at least partially located in the groove.