Abstract: Methods and systems are provided for isolating fetal cells from a maternal blood supply in order to perform non-invasive prenatal testing. In one example, a system for non-invasive prenatal testing includes a substrate coated with a cell-capturing surface, the cell-capturing surface including an array of pillar-like structures, each pillar-like structure including a plurality of intersecting arms.

Abstract: A biocompatible micropillar array substrate (MAS) and methods for preparing the biocompatible MAS are provided. In on example, the biocompatible MAS includes multiple micropillars made from a biocompatible polymer. The biocompatible MAS may be prepared using a replica fabricated based on a silicon MAS. The configuration of the multiple micropillars of the silicon MAS and a configuration of the multiple micropillars of the biocompatible MAS are the same.

Abstract: A mechanical-hydraulic integrated releasing device includes an upper joint, a lower joint and a pawl. The upper joint and the lower joint are respectively connected to two ends of the pawl. An outer side of the pawl is sleeved with a releasing sleeve capable of moving in an axial direction of the pawl. A step is arranged on an outer wall of a ratchet of the pawl. A groove matching the step is arranged on an inner wall of the releasing sleeve, and the step and the groove cooperate to limit the pawl. A releasing sleeve upper portion is arranged between the releasing sleeve and the upper joint, one end of the releasing sleeve upper portion is inserted into the releasing sleeve, and the other end is sleeved on an outer portion of the upper joint and connected to the upper joint via a start pin.

Abstract: Methods and systems are provided for isolating circulating tumor cells from a peripheral blood supply in order to diagnose early stage cancer and/or evaluate tumor status. In one example, a system for capturing circulating tumor cells includes a substrate having a cell-capturing region, the cell-capturing region having a curved, switchback-like shape and including an array of micropillar structures within the curved, switchback-like shape.

Abstract: Methods and systems are provided for isolating fetal cells from a maternal blood supply in order to perform non-invasive prenatal testing. In one example, a system for non-invasive prenatal testing includes a substrate coated with a cell-capturing surface, the cell-capturing surface including an array of pillar-like structures, each pillar-like structure including a plurality of intersecting arms.

Abstract: Methods and systems are provided for isolating fetal cells from a maternal blood supply in order to perform non-invasive prenatal testing. In one example, a system for non-invasive prenatal testing includes a substrate coated with a cell-capturing surface, the cell-capturing surface including an array of pillar-like structures, each pillar-like structure including a plurality of intersecting arms.

Abstract: This application relates to apparatus and methods for identifying fraudulent transactions. A computing device receives return data identifying the return of at least one item. The computing device obtains modified strategy data identifying at least one rule of a modified strategy. The rule may be based on the application of at least one discrete stochastic gradient descent algorithm to an initial strategy. The computing device applies the modified strategy to the received return data identifying the return of the at least one item, and determines whether the return of the at least one item is fraudulent based on the application of the modified strategy. The computing device generates fraud data identifying whether the return of the at least one item is fraudulent based on the determination, and may transmit the fraud data to another computing device to indicate whether the return is fraudulent.

Abstract: This application relates to apparatus and methods for identifying fraudulent transactions. A computing device receives return data identifying the return of at least one item. The computing device obtains modified strategy data identifying at least one rule of a modified strategy. The rule may be based on the application of at least one dimensionality reduction algorithm to an initial strategy. The computing device applies the modified strategy to the received return data identifying the return of the at least one item, and determines whether the return of the at least one item is fraudulent based on the application of the modified strategy. The computing device generates fraud data identifying whether the return of the at least one item is fraudulent based on the determination, and may transmit the fraud data to another computing device to indicate whether the return is fraudulent.

Abstract: This application relates to apparatus and methods for identifying anomalies within a time series. In some examples, a computing device receives sales data identifying a sale of at least one item, and aggregates the received data in a database. The computing device may generate a plurality of time series based on the aggregated sales data. The computing device may extract features from the plurality of time series, and generate an alerting algorithm that is based on clusters of the extracted features. The computing device may apply the alerting algorithm to a time series generated from received sales data to determine whether the time series is an anomaly. Based on the determination, the computing device may generate and transmit anomaly data identifying whether the time series is an anomaly, such as to another computing device.

Abstract: Aspects of the present disclosure involve a system and method for learning from images of raw data, including transactional data. In one embodiment, a system is introduced that can learn from the images of such data. In particular, machine learning is implemented on images in order to classify information in a more accurate manner. The images are created from raw data deriving from data sources relating to user accounts, in various embodiments.

Abstract: Methods and systems are provided for isolating fetal cells from a maternal blood supply in order to perform non-invasive prenatal testing. In one example, a system for non-invasive prenatal testing includes a substrate coated with a cell-capturing surface, the cell-capturing surface including an array of pillar-like structures, each pillar-like structure including a plurality of intersecting arms.

Abstract: Methods and systems are provided for isolating circulating tumor cells from a peripheral blood supply in order to diagnose early stage cancer and/or evaluate tumor status. In one example, a system for capturing circulating tumor cells includes a substrate having a cell-capturing region, the cell-capturing region having a curved, switchback-like shape and including an array of micropillar structures within the curved, switchback-like shape.

Abstract: A biocompatible micropillar array substrate (MAS) and methods for preparing the biocompatible MAS are provided. In on example, the biocompatible MAS includes multiple micropillars made from a biocompatible polymer. The biocompatible MAS may be prepared using a replica fabricated based on a silicon MAS. The configuration of the multiple micropillars of the silicon MAS and a configuration of the multiple micropillars of the biocompatible MAS are the same.

Abstract: Methods and systems are provided for isolating fetal cells from a maternal blood supply in order to perform non-invasive prenatal testing. In one example, a system for non-invasive prenatal testing includes a substrate coated with a cell-capturing surface, the cell-capturing surface including an array of pillar-like structures, each pillar-like structure including a plurality of intersecting arms.

Abstract: A biocompatible micropillar array substrate (MAS) and methods for preparing the biocompatible MAS are provided. In on example, the biocompatible MAS includes multiple micropillars made from a biocompatible polymer. The biocompatible MAS may be prepared using a replica fabricated based on a silicon MAS. The configuration of the multiple micropillars of the silicon MAS and a configuration of the multiple micropillars of the biocompatible MAS are the same.

Abstract: Methods and systems are provided for isolating circulating tumor cells from a peripheral blood supply in order to diagnose early stage cancer and/or evaluate tumor status. In one example, a system for capturing circulating tumor cells includes a substrate having a cell-capturing region, the cell-capturing region having a curved, switchback-like shape and including an array of micropillar structures within the curved, switchback-like shape.

Abstract: Methods and systems are provided for isolating fetal cells from a maternal blood supply in order to perform non-invasive prenatal testing. In one example, a system for non-invasive prenatal testing includes a substrate coated with a cell-capturing surface, the cell-capturing surface including an array of pillar-like structures, each pillar-like structure including a plurality of intersecting arms.

Abstract: A mechanical-hydraulic integrated releasing device includes an upper joint, a lower joint and a pawl. The upper joint and the lower joint are respectively connected to two ends of the pawl. An outer side of the pawl is sleeved with a releasing sleeve capable of moving in an axial direction of the pawl. A step is arranged on an outer wall of a ratchet of the pawl. A groove matching the step is arranged on an inner wall of the releasing sleeve, and the step and the groove cooperate to limit the pawl. A releasing sleeve upper portion is arranged between the releasing sleeve and the upper joint, one end of the releasing sleeve upper portion is inserted into the releasing sleeve, and the other end is sleeved on an outer portion of the upper joint and connected to the upper joint via a start pin.

Abstract: Improved systems and methods for collecting, isolating and analyzing trophoblasts from the endocervical canal for prenatal genetic testing are disclosed. Particularly, an endocervical sample collection device is disclosed, where that collection device is enhanced with surface nanostructures/microstructures and functionalized with trophoblast specific antibodies to allow the collection device to preferentially adhere to and pick up fetal trophoblasts as opposed to maternal cells and/or non-cellular materials such as endocervical mucus. In addition, a non-caustic mucolytic preparation for treating endocervical sample to remove mucus while keeping the trophoblast cells intact and viable for downstream culturing and processing is disclosed.

Abstract: Aspects of the present disclosure involve a system and method for learning from images of raw data, including transactional data. In one embodiment, a system is introduced that can learn from the images of such data. In particular, machine learning is implemented on images in order to classify information in a more accurate manner. The images are created from raw data deriving from data sources relating to user accounts, in various embodiments.